Organophosphates Questions & Answers

Updated: Jun 15, 2020
  • Author: Frances M Dyro, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Questions & Answers

Overview

What are organophosphates (OPs)?

What are the therapeutic uses of organophosphates (OPs)?

What are the historic uses of organophosphates (OPs)?

What is the mechanism of action of organophosphates (OPs)?

What is the pathophysiology of delayed neurotoxicity of organophosphates (OPs)?

What is the prevalence of organophosphate exposure in the US?

What is the global prevalence of organophosphate exposure?

What is the mortality and morbidity associated with organophosphate exposure?

What are the racial predilections of organophosphate exposure?

What are the sexual predilections of organophosphate exposure?

Which age groups have the highest prevalence of organophosphate exposure?

Presentation

Which clinical history findings are characteristic of organophosphate exposure?

What are the signs and symptoms of organophosphate exposure?

Which physical findings are characteristic of organophosphate exposure?

What causes organophosphate toxicity?

DDX

What are the differential diagnoses for Organophosphates?

Workup

What is the role of lab tests in the workup of organophosphate exposure?

What is the role of imaging studies in the workup of organophosphate exposure?

What is the role of electrophysiologic studies in the workup of organophosphate exposure?

What is the role of ECG in the workup of organophosphate exposure?

What is the role of neuropsychological testing in the workup of organophosphate exposure?

Which histologic findings are characteristic of organophosphate exposure?

Treatment

How is organophosphate toxicity treated?

What is the role of surgery in the treatment of organophosphate exposure?

Which specialist consultations are beneficial to patients with organophosphate exposure?

Which dietary modifications are used in the treatment of organophosphate exposure?

Which activity modifications are used in the treatment of organophosphate exposure?

Medications

What is the role of medications in the treatment of organophosphate exposure?

Which medications in the drug class Anticholinergic agents are used in the treatment of Organophosphates?

Which medications in the drug class Antidotes are used in the treatment of Organophosphates?

Follow-up

What is included in long-term monitoring following organophosphate exposure?

What are the secondary morbidities of organophosphate exposure?

Which medications are used in the treatment of organophosphate exposure?

When is patient transfer indicated for the treatment of organophosphate exposure?

How is organophosphate exposure prevented?

What are the possible complications of organophosphate exposure?

What is the prognosis of organophosphate exposure?

What is included in patient education about organophosphate exposure?