Pediatric Febrile Seizures Medication

Updated: Nov 17, 2016
  • Author: Robert J Baumann, MD; Chief Editor: Amy Kao, MD  more...
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Medication Summary

On the basis of risk/benefit analysis, neither long-term nor intermittent anticonvulsant therapy is indicated for children who have experienced 1 or more simple febrile seizures. In unusual circumstances, oral diazepam can be given with each fever.



Class Summary

These agents have antiseizure activity and act rapidly in acute seizures.

Diazepam (Diastat Pediatric, Valium)

Oral diazepam can decrease number of subsequent febrile seizures when given with each febrile episode. Many practitioners will prescribe rectal diazepam, particularly to patients who have had prolonged febrile seizures, in order to prevent future episodes of febrile status epilepticus. By increasing activity of GABA, a major inhibitory neurotransmitter, depresses all levels of CNS, including limbic and reticular formation.

A study reported in New England Journal of Medicine continued oral diazepam therapy until child was afebrile for 24 h. However, this seems excessive.