Lennox-Gastaut Syndrome Questions & Answers

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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Questions & Answers

Overview

What are the clinical features of Lennox-Gastaut syndrome (LGS)?

Which factors increase the risk for cognitive impairment in Lennox-Gastaut syndrome (LGS)?

What types of seizures occur in Lennox-Gastaut syndrome (LGS)?

Which physical findings are characteristic of Lennox-Gastaut syndrome (LGS)?

Which findings on EEG are characteristic of Lennox-Gastaut syndrome (LGS)?

What is the role of neuroimaging in the workup of Lennox-Gastaut syndrome (LGS)?

Which medications are used in the treatment of Lennox-Gastaut syndrome (LGS)?

Which surgical interventions are used in the treatment of Lennox-Gastaut syndrome (LGS)?

Which dietary modifications are used in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the Lennox-Gastaut syndrome (LGS)?

What is the pathophysiology of Lennox-Gastaut syndrome (LGS)?

How is Lennox-Gastaut syndrome (LGS) classified?

What causes Lennox-Gastaut syndrome (LGS)?

What is cryptogenic Lennox-Gastaut syndrome (LGS)?

What is the ILAE classification of Lennox-Gastaut syndrome (LGS)?

What is the prevalence of Lennox-Gastaut syndrome (LGS)?

What is the prognosis of Lennox-Gastaut syndrome (LGS)?

What is included in patient education about Lennox-Gastaut syndrome (LGS)?

Presentation

What are the prognostic factors in Lennox-Gastaut syndrome (LGS)?

Which clinical history findings are characteristic of Lennox-Gastaut syndrome (LGS)?

How are seizures characterized in Lennox-Gastaut syndrome (LGS)?

Which physical findings are pathognomonic for Lennox-Gastaut syndrome (LGS)?

Which neurologic findings are characteristic of Lennox-Gastaut syndrome (LGS)?

What are the possible complications of Lennox-Gastaut syndrome (LGS)?

DDX

Which conditions are included in the differential diagnoses of Lennox-Gastaut syndrome (LGS)?

What are the differential diagnoses for Lennox-Gastaut Syndrome?

Workup

How is Lennox-Gastaut syndrome (LGS) diagnosed?

What is the role of EEG in the workup of Lennox-Gastaut syndrome (LGS)?

What is the role of interictal EEG in the workup of Lennox-Gastaut syndrome (LGS)?

What is the role of ictal EEG in the workup of Lennox-Gastaut syndrome (LGS)?

What is the role of imaging studies in the workup of Lennox-Gastaut syndrome (LGS)?

Treatment

How is Lennox-Gastaut syndrome (LGS) treated?

What is the role of medications in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of antiepileptic drugs (AEDs) in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of valproate (Depakote, Depakene, Depacon) in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of lamotrigine (Lamictal) in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of topiramate (Topamax) in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of felbamate (Felbatol) in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of zonisamide (Zonegran) in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of vigabatrin (Sabril) in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of rufinamide (Banzel) in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of benzodiazepines in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of cannabidiol in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of corpus callosotomy in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of vagus nerve stimulation in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of focal cortical resection in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of a ketogenic diet in the treatment of Lennox-Gastaut syndrome (LGS)?

Which factors are associated with successful implementation of a ketogenic diet in the treatment of Lennox-Gastaut syndrome (LGS)?

What are the possible adverse effects of a ketogenic diet in the treatment of Lennox-Gastaut syndrome (LGS)?

What is the role of protective helmets in the treatment of Lennox-Gastaut syndrome (LGS)?

Which specialist consultations are beneficial to patients with Lennox-Gastaut syndrome (LGS)?

Medications

What are the goals of medical treatment for Lennox-Gastaut syndrome (LGS)?

Which medications in the drug class Benzodiazepines are used in the treatment of Lennox-Gastaut Syndrome?

Which medications in the drug class Anticonvulsants are used in the treatment of Lennox-Gastaut Syndrome?