Childhood Migraine Variants Differential Diagnoses

1. Headache Classification Committee of the International Headache Society (IHS). Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018 Jan. 38 (1):1-211. [QxMD MEDLINE Link].

2. Gelfand AA, Thomas KC, Goadsby PJ. Before the headache: infant colic as an early life expression of migraine. Neurology. 2012 Sep 25. 79(13):1392-6. [QxMD MEDLINE Link].

3. Romanello S, Spiri D, Marcuzzi E, Zanin A, Boizeau P, Riviere S. Association between childhood migraine and history of infantile colic. JAMA. 2013 Apr 17. 309(15):1607-12. [QxMD MEDLINE Link].

4. Hansen JM, Hauge AW, Ashina M, Olesen J. Trigger factors for familial hemiplegic migraine. Cephalalgia. 2011 Sep. 31(12):1274-81. [QxMD MEDLINE Link].

5. Haan J, Terwindt GM, Maassen JA, et al. Search for mitochondrial DNA mutations in migraine subgroups. Cephalalgia. 1999 Jan. 19(1):20-2. [QxMD MEDLINE Link].

6. Zaki EA, Freilinger T, Klopstock T, Baldwin EE, Heisner KR, Adams K, et al. Two common mitochondrial DNA polymorphisms are highly associated with migraine headache and cyclic vomiting syndrome. Cephalalgia. 2009 Jul. 29(7):719-28. [QxMD MEDLINE Link].

7. Frosk P, Mhanni AA, Rafay MF. SCN1A mutation associated with intractable myoclonic epilepsy and migraine headache. J Child Neurol. 2013 Mar. 28(3):389-91. [QxMD MEDLINE Link].

8. Marini C, Conti V, Mei D, Battaglia D, Lettori D, Losito E, et al. PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine. Neurology. 2012 Nov 20. 79(21):2109-14. [QxMD MEDLINE Link]. [Full Text].

9. Silveira-Moriyama L, Gardiner AR, Meyer E, King MD, Smith M, Rakshi K. Clinical features of childhood-onset paroxysmal kinesigenic dyskinesia with PRRT2 gene mutations. Dev Med Child Neurol. 2013 Apr. 55(4):327-34. [QxMD MEDLINE Link].

10. De Cunto A, Bensa M, Tonelli A. A case of familial hemiplegic migraine associated with a novel ATP1A2 gene mutation. Pediatr Neurol. 2012 Aug. 47(2):133-6. [QxMD MEDLINE Link].

11. Jurkat-Rott K, Freilinger T, Dreier JP, et al. Variability of familial hemiplegic migraine with novel A1A2 Na+/K+-ATPase variants. Neurology. 2004 May 25. 62(10):1857-61. [QxMD MEDLINE Link].

12. Swoboda KJ, Kanavakis E, Xaidara A, et al. Alternating hemiplegia of childhood or familial hemiplegic migraine? A novel ATP1A2 mutation. Ann Neurol. 2004 Jun. 55(6):884-7. [QxMD MEDLINE Link].

13. Ducros A, Joutel A, Vahedi K, et al. Mapping of a second locus for familial hemiplegic migraine to 1q21-q23 and evidence of further heterogeneity. Ann Neurol. 1997 Dec. 42(6):885-90. [QxMD MEDLINE Link].

14. Gardner K, Barmada MM, Ptacek LJ, Hoffman EP. A new locus for hemiplegic migraine maps to chromosome 1q31. Neurology. 1997 Nov. 49(5):1231-8. [QxMD MEDLINE Link].

15. Beauvais K, Cave-Riant F, De Barace C, et al. New CACNA1A gene mutation in a case of familial hemiplegic migraine with status epilepticus. Eur Neurol. 2004. 52(1):58-61. [QxMD MEDLINE Link].

16. Terwindt G, Kors E, Haan J, et al. Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. Arch Neurol. 2002 Jun. 59(6):1016-8. [QxMD MEDLINE Link].

17. Asghar SJ, Milesi-Hallé A, Kaushik C, Glasier C, Sharp GB. Variable manifestations of familial hemiplegic migraine associated with reversible cerebral edema in children. Pediatr Neurol. 2012 Sep. 47(3):201-4. [QxMD MEDLINE Link].

18. Lanska JR, Lanska DJ. Alice in Wonderland Syndrome: somesthetic vs visual perceptual disturbance. Neurology. 2013 Mar 26. 80(13):1262-4. [QxMD MEDLINE Link].

19. Golomb MR, Sokol DK, Walsh LE, et al. Recurrent hemiplegia, normal MRI, and NOTCH3 mutation in a 14-year-old: is this early CADASIL?. Neurology. 2004 Jun 22. 62(12):2331-2. [QxMD MEDLINE Link].

20. Lewis DW, Ashwal S, Dahl G, et al. Practice parameter: evaluation of children and adolescents with recurrent headaches: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2002 Aug 27. 59(4):490-8. [QxMD MEDLINE Link].

21. Lewis D, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology. 2004 Dec 28. 63(12):2215-24. [QxMD MEDLINE Link].

22. Evans RW, Taylor FR. "Natural" or alternative medications for migraine prevention. Headache. 2006 Jun. 46(6):1012-8. [QxMD MEDLINE Link].

23. Ahonen K, Hamalainen ML, Rantala H, Hoppu K. Nasal sumatriptan is effective in treatment of migraine attacks in children: A randomized trial. Neurology. 2004 Mar 23. 62(6):883-7. [QxMD MEDLINE Link].

24. Evers S, Rahmann A, Kraemer C, et al. Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen. Neurology. 2006 Aug 8. 67(3):497-9. [QxMD MEDLINE Link].

25. Cloarec R, Bruneau N, Rudolf G, Massacrier A, Salmi M, Bataillard M. PRRT2 links infantile convulsions and paroxysmal dyskinesia with migraine. Neurology. 2012 Nov 20. 79(21):2097-103. [QxMD MEDLINE Link].

26. Gardiner AR, Bhatia KP, Stamelou M, Dale RC, Kurian MA, Schneider SA, et al. PRRT2 gene mutations: from paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine. Neurology. 2012 Nov 20. 79(21):2115-21. [QxMD MEDLINE Link]. [Full Text].

27. Langhagen T, Schroeder AS, Rettinger N, Borggraefe I, Jahn K. Migraine-related vertigo and somatoform vertigo frequently occur in children and are often associated. Neuropediatrics. 2013 Feb. 44(1):55-8. [QxMD MEDLINE Link].

Wendy G Mitchell, MD Professor of Neurology, Keck School of Medicine of the University of Southern California; Consulting Staff, Division of Child Neurology, Children's Hospital Los Angeles, LAC+USC Medical Center

Wendy G Mitchell, MD is a member of the following medical societies: American Academy of Neurology, Child Neurology Society, International Child Neurology Association

Disclosure: Received income in an amount equal to or greater than $250 from: UCB.

Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP, FANA Professor of Pediatrics, Neurology, Neurosurgery, and Psychiatry, Medical Director, Tulane Center for Autism and Related Disorders, Tulane University School of Medicine; Pediatric Neurologist and Epileptologist, Ochsner Hospital for Children; Professor of Neurology, Louisiana State University School of Medicine

Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP, FANA is a member of the following medical societies: American Academy for Cerebral Palsy and Developmental Medicine, American Academy of Neurology, American Academy of Pediatrics, American Epilepsy Society, American Medical Association, American Neurological Association, Association of Military Surgeons of the US, Child Neurology Society, Southern Pediatric Neurology Society

Disclosure: Nothing to disclose.

James J Riviello Jr, MD George Peterkin Endowed Chair in Pediatrics, Professor of Pediatrics, Section of Neurology and Developmental Neuroscience, Professor of Neurology, Peter Kellaway Section of Neurophysiology, Baylor College of Medicine; Chief of Neurophysiology, Director of the Epilepsy and Neurophysiology Program, Texas Children's Hospital

James J Riviello Jr, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Up To Date Royalty Section Editor

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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