Euthyroid Hyperthyroxinemia Clinical Presentation

Updated: Mar 03, 2023
  • Author: Justyna Bart, MD, PhD; Chief Editor: George T Griffing, MD  more...
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Patients with euthyroid hyperthyroxinemia are usually asymptomatic. They do not manifest any physical signs other than those pertinent to their underlying pathology.

A history of drug intake may include the following [21] :

  • Oral contraceptives or estrogen replacement [30]

  • Amiodarone

  • Propranolol [23]

  • Heparin

  • Perphenazine [31]

  • Clofibrate [31]

  • 5-Fluorouracil [32]

  • Lithium [33]

A history of drug abuse may include the following:

  • Heroin [34]

  • Methadone [34]

A history of chronic diseases may include the following:

  • Liver diseases - Active hepatitis, chronic hepatitis, biliary cirrhosis

  • Human immunodeficiency virus (HIV) infection [35]

  • Acute intermittent porphyria

  • Malignant diseases - Islet cell tumors and glucagonomas

A history of psychiatric conditions, including acute psychosis, can be associated.

The patient's family history is an important aspect of diagnosis because one of the most revealing clues in the diagnosis of hereditary conditions is the discovery of another family member with the same laboratory abnormalities.