Euthyroid Hyperthyroxinemia Medication

1. Borst GC, Eil C, Burman KD. Euthyroid hyperthyroxinemia. Ann Intern Med. 1983 Mar. 98(3):366-78. [QxMD MEDLINE Link].

2. Vaidya B, Hubalewska-Dydejczyk A, Laurberg P, Negro R, Vermiglio F, Poppe KG. Treatment and Screening of Hypothyroidism in Pregnancy: Results of a European Survey. Eur J Endocrinol. 2011 Oct 24. [QxMD MEDLINE Link].

3. Kvetny J, Poulsen H. Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. J Matern Fetal Neonatal Med. 2006 Dec. 19(12):817-22. [QxMD MEDLINE Link].

4. Moses AC, Rosen HN, Moller DE, et al. A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. J Clin Invest. 1990 Dec. 86(6):2025-33. [QxMD MEDLINE Link]. [Full Text].

5. Hishinuma A, Mochizuki Y, Kasai K, et al. [Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. Nippon Rinsho. 1994 Apr. 52(4):886-9. [QxMD MEDLINE Link].

6. Magalhães PK, Rodrigues Dare GL, Rodrigues Dos Santos S, et al. Clinical features and genetic analysis of four Brazilian kindreds with resistance to thyroid hormone. Clin Endocrinol (Oxf). 2007 Nov. 67(5):748-53. [QxMD MEDLINE Link].

7. Tucker WS Jr. Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin. South Med J. 1989 Mar. 82(3):368-71. [QxMD MEDLINE Link].

8. Maye P, Bisetti A, Burger A, et al. Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour. Acta Endocrinol (Copenh). 1989 Jan. 120(1):87-91. [QxMD MEDLINE Link].

9. Refetoff S, Marinov VS, Tunca H, Byrne MM, Sunthornthepvarakul T, Weiss RE. A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. J Clin Endocrinol Metab. 1996 Sep. 81(9):3335-40. [QxMD MEDLINE Link].

10. Moses AC, Rosen HN, Moller DE, Tsuzaki S, Haddow JE, Lawlor J, et al. A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. J Clin Invest. 1990 Dec. 86(6):2025-33. [QxMD MEDLINE Link]. [Full Text].

11. Gharib H, Klee GG. Familial euthyroid hyperthyroxinemia secondary to pituitary and peripheral resistance to thyroid hormones. Mayo Clin Proc. 1985 Jan. 60(1):9-15. [QxMD MEDLINE Link].

12. Rushbrook JI, Becker E, Schussler GC, et al. Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. J Clin Endocrinol Metab. 1995 Feb. 80(2):461-7. [QxMD MEDLINE Link]. [Full Text].

13. Schoenmakers N, Moran C, Campi I, et al. A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. J Clin Endocrinol Metab. 2014 Jul. 99(7):E1381-6. [QxMD MEDLINE Link]. [Full Text].

14. Wada N, Chiba H, Shimizu C, Kijima H, Kubo M, Koike T. A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. J Clin Endocrinol Metab. 1997 Oct. 82(10):3246-50. [QxMD MEDLINE Link].

15. Pannain S, Feldman M, Eiholzer U, Weiss RE, Scherberg NH, Refetoff S. Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. J Clin Endocrinol Metab. 2000 Aug. 85(8):2786-92. [QxMD MEDLINE Link].

16. Greenberg SM, Ferrara AM, Nicholas ES, Dumitrescu AM, Cody V, Weiss RE, et al. A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. Thyroid. 2014 Jun. 24(6):945-50. [QxMD MEDLINE Link]. [Full Text].

17. Eber O, Langsteger W, Florian W, et al. [Evaluating thyroid gland function in patients with protein anomalies]. Acta Med Austriaca. 1991. 18(1):11-9. [QxMD MEDLINE Link].

18. George PM, Sheat JM, Palmer BN. Detection of protein binding abnormalities in euthyroid hyperthyroxinemia. Clin Chem. 1988 Sep. 34(9):1745-8. [QxMD MEDLINE Link]. [Full Text].

19. Zhao L, Zhou Y, Huang F, et al. Clinical characteristics of familial dysalbuminemic hyperthyroxinemia in Chinese patients and comparison of free thyroxine in three immunoassay methods. Front Endocrinol (Lausanne). 2023. 14:1102777. [QxMD MEDLINE Link].

20. Moran C, Seger C, Taylor K, et al. Hyperthyroxinemia and Hypercortisolemia due to Familial Dysalbuminemia. Thyroid. 2020 Nov. 30 (11):1681-4. [QxMD MEDLINE Link]. [Full Text].

21. Molashenko NV, Sviridenko NIu, Platonova NM, et al. [The specific features of thyrotoxicosis and euthyroid hyperthyroxinemia developed due to the use of cordarone]. Klin Med (Mosk). 2004. 82(12):35-9. [QxMD MEDLINE Link].

22. Jackson JA, Verdonk CA, Spiekerman AM. Euthyroid hyperthyroxinemia and inappropriate secretion of thyrotropin. Recognition and diagnosis. Arch Intern Med. 1987 Jul. 147(7):1311-3. [QxMD MEDLINE Link].

23. Mooradian A, Morley JE, Simon G, et al. Propranolol-induced hyperthyroxinemia. Arch Intern Med. 1983 Nov. 143(11):2193-5. [QxMD MEDLINE Link].

24. Loh TP, Leong SM, Loke KY, Deepak DS. Spuriously elevated free thyroxine associated with autoantibodies, a result of laboratory methodology: case report and literature review. Endocr Pract. 2014 Aug 1. 20(8):e134-9. [QxMD MEDLINE Link].

25. Cogan E, Abramow M. Transient hyperthyroxinemia in symptomatic hyponatremic patients. Arch Intern Med. 1986 Mar. 146(3):545-7. [QxMD MEDLINE Link].

26. Tang KT, Yang HJ, Choo KB, et al. A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. Eur J Endocrinol. 1999 Oct. 141(4):374-8. [QxMD MEDLINE Link]. [Full Text].

27. Wada N, Chiba H, Shimizu C, et al. A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. J Clin Endocrinol Metab. 1997 Oct. 82(10):3246-50. [QxMD MEDLINE Link]. [Full Text].

28. Yeap BB, Alfonso H, Chubb SA, Walsh JP, Hankey GJ, Almeida OP, et al. Higher free thyroxine levels are associated with frailty in older men. The Health In Men Study. Clin Endocrinol (Oxf). 2011 Nov 11. [QxMD MEDLINE Link].

29. Yeap BB, Alfonso H, Hankey G, Flicker L, Golledge J, Norman PE, et al. Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men. The Health In Men Study. Eur J Endocrinol. 2013 Jul 12. [QxMD MEDLINE Link].

30. Sänger N, Stahlberg S, Manthey T, et al. Effects of an oral contraceptive containing 30 mcg ethinyl estradiol and 2 mg dienogest on thyroid hormones and androgen parameters: conventional vs. extended-cycle use. Contraception. 2008 Jun. 77(6):420-5. [QxMD MEDLINE Link].

31. McKerron CG, Scott RL, Asper SP, Levy RI. Effects of clofibrate (Atromid S) on the thyroxine-binding capacity of thyroxine-binding globulin and free thyroxine. J Clin Endocrinol Metab. 1969 Jul. 29(7):957-61. [QxMD MEDLINE Link].

32. Beex LV, Ross A, Smals AG, Kloppenborg PW. Letter: 5-fluorouracil and the thyroid. Lancet. 1976 Apr 17. 1(7964):866-7. [QxMD MEDLINE Link].

33. Chekuri L, Lange JR, Thapa PB. Lithium-induced transient euthyroid hyperthyroxinemia: a case report. Prim Care Companion CNS Disord. 2014. 16(2):[QxMD MEDLINE Link]. [Full Text].

34. Azizi F, Vagenakis AG, Portnay GI, Braverman LE, Ingbar SH. Thyroxine transport and metabolism in methadone and heroin addicts. Ann Intern Med. 1974 Feb. 80(2):194-9. [QxMD MEDLINE Link].

35. Wiener M, Lo Y, Klein R. Abnormal thyroid function in older men with or at risk for HIV infection. HIV Med. 2008 Jun 11. [QxMD MEDLINE Link].

36. Stockigt JR, Barlow JW. The diagnostic challenge of euthyroid hyperthyroxinemia. Aust N Z J Med. 1985 Apr. 15(2):277-84. [QxMD MEDLINE Link].

Justyna Bart, MD, PhD Hospitalist, Rehabilitation Department, UPMC Hospitalist Program

Justyna Bart, MD, PhD is a member of the following medical societies: American College of Physicians, American Medical Association, Pennsylvania Medical Society

Disclosure: Nothing to disclose.

Jane V Mayrin, MD, FACE Staff Attending Physician, Einstein Endocrine Associates, Albert Einstein Medical Center; Staff Endocrinologist, Kindred Hospital

Jane V Mayrin, MD, FACE is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Medical Association, American Thyroid Association, Endocrine Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Romesh Khardori, MD, PhD, FACP (Retired) Professor, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Eastern Virginia Medical School

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, Endocrine Society

Disclosure: Nothing to disclose.

George T Griffing, MD Professor Emeritus of Medicine, St Louis University School of Medicine

George T Griffing, MD is a member of the following medical societies: American Association for Physician Leadership, American Association for the Advancement of Science, American College of Medical Practice Executives, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical and Translational Research, Endocrine Society, International Society for Clinical Densitometry, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Steven R Gambert, MD Professor of Medicine, Johns Hopkins University School of Medicine; Director of Geriatric Medicine, University of Maryland Medical Center and R Adams Cowley Shock Trauma Center

Steven R Gambert, MD is a member of the following medical societies: Alpha Omega Alpha, American Association for Physician Leadership, American College of Physicians, American Geriatrics Society, Endocrine Society, Gerontological Society of America, Association of Professors of Medicine

Disclosure: Nothing to disclose.

Serge A Jabbour, MD, FACP, FACE Professor of Medicine, Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University

Serge A Jabbour, MD, FACP, FACE is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians-American Society of Internal Medicine, American Diabetes Association, American Medical Association, American Thyroid Association, Pennsylvania Medical Society, and The Endocrine Society

Disclosure: Nothing to disclose.

Reetu Singh, MD Fellow, Department of Internal Medicine, Beebe Medical Center

Reetu Singh, MD is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Diabetes Association, American Thyroid Association, and The Endocrine Society

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