Euthyroid Sick Syndrome Questions & Answers

Updated: Oct 08, 2018
  • Author: Serhat Aytug, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
  • Print
Questions & Answers

Overview

What euthyroid sick syndrome?

Which conditions are associated with euthyroid sick syndrome?

What causes abnormal thyroid function test findings in euthyroid sick syndrome?

What is the role of thyroid function test accuracy in euthyroid sick syndrome?

What is the role of thyroid hormone binding inhibition in the pathophysiology of euthyroid sick syndrome?

What is the role of cytokines in the pathophysiology of euthyroid sick syndrome?

What is the role of deiodination in the pathophysiology of euthyroid sick syndrome?

What is the role of TRH and TSH inhibition in the pathophysiology of euthyroid sick syndrome?

What is the role of plasma membrane transport of iodothyronines in the pathophysiology of euthyroid sick syndrome?

What is the role of thyroxine-binding globulin in the pathophysiology of euthyroid sick syndrome?

What is the role of triiodothyronine and reverse triiodothyronine in the pathophysiology of euthyroid sick syndrome?

What is the role of free triiodothyronine (FT3) hormones in the pathophysiology of euthyroid sick syndrome?

What is the role of thyroxine in the pathophysiology of euthyroid sick syndrome?

What is the role of free thyroxine in the pathophysiology of euthyroid sick syndrome?

What is the role of thyroid hormone receptor expression in the pathophysiology of euthyroid sick syndrome?

What methods are used to measure free thyroxine in euthyroid sick syndrome?

How are TSH and TRH measured in euthyroid sick syndrome?

What is the prevalence of euthyroid sick syndrome in the US?

What is the global prevalence of euthyroid sick syndrome?

What is the mortality and morbidity associated with euthyroid sick syndrome?

What is the racial predilection of euthyroid sick syndrome?

What are the sexual predilections of euthyroid sick syndrome?

How does the prevalence of euthyroid sick syndrome vary by age?

Presentation

Which clinical history findings are characteristic of euthyroid sick syndrome?

Which physical findings are characteristic of euthyroid sick syndrome?

What causes euthyroid sick syndrome?

DDX

Which drugs influence thyroid function in euthyroid sick syndrome?

What is the role of increased temperature in the development of euthyroid sick syndrome?

What is the role of thermal injury in the development of euthyroid sick syndrome?

What is the role of acute cold in the development of euthyroid sick syndrome?

What is the role of starvation in the development of euthyroid sick syndrome?

What is the role of malnutrition in the development of euthyroid sick syndrome?

What is the role of obesity in the development of euthyroid sick syndrome?

What is the role of surgery in the development of euthyroid sick syndrome?

What is the role of myocardial infarction in the development of euthyroid sick syndrome?

What is the role of renal disease in the development of euthyroid sick syndrome?

What is the role of liver disease in the development of euthyroid sick syndrome?

What is the role of hepatitis in the development of euthyroid sick syndrome?

What is the role of infection in the development of euthyroid sick syndrome?

What is the role of HIV infection in the development of euthyroid sick syndrome?

What is the role of bone marrow transplantation in the development of euthyroid sick syndrome?

What is the role of malignancy in the development of euthyroid sick syndrome?

What is the role of subarachnoid hemorrhage in the development of euthyroid sick syndrome?

What is the role of psychiatric illness in the development of euthyroid sick syndrome?

What is the role of anorexia nervosa in the development of euthyroid sick syndrome?

What are the differential diagnoses for Euthyroid Sick Syndrome?

Workup

What is the role of lab testing in the diagnosis of euthyroid sick syndrome?

What is the role of imaging studies in the diagnosis of euthyroid sick syndrome?

What is the role of biopsy in the diagnosis of euthyroid sick syndrome?

Which histologic findings are characteristic of euthyroid sick syndrome?

How is euthyroid sick syndrome staged?

Treatment

How is euthyroid sick syndrome treated?

Which specialist consultations are beneficial to patients with euthyroid sick syndrome?

Which dietary modifications are used in the treatment of euthyroid sick syndrome?

Which activity modifications are used in the treatment of euthyroid sick syndrome?

Medications

What is the role of medications in the treatment of euthyroid sick syndrome?

Follow-up

What is included in the long-term monitoring of patients with euthyroid sick syndrome?

When is inpatient care indicated in the treatment of euthyroid sick syndrome?

What are the possible complications of euthyroid sick syndrome?

What is the prognosis of euthyroid sick syndrome?

What is included in patient education about euthyroid sick syndrome?