Euthyroid Sick Syndrome Workup

Updated: Oct 06, 2022
  • Author: Serhat Aytug, MD, FACE; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Workup

Laboratory Studies

Typical NTI findings are T4 level within the reference range, low T3 level, slightly reduced or reference range level of TSH, elevated rT3 level, and a free T4 level that is within the reference range or is elevated.

In severe NTI, the findings are low T4, low T3, reduced TSH, elevated rT3, and free T4 that is within the reference range or is diminished.

Recommended tests include the following:

  • Total T4

  • Total T3

  • TSH

  • Free T4

  • rT3

  • Free T3

Refer to specific nonthyroidal diseases for particular alterations in thyroid function test results.

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Imaging Studies

No specific imaging study can be used to diagnose an NTI.

Thyroid sonogram, thyroid uptake and scan, and other radiological studies have no role in the diagnosis of NTI.

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Procedures

Thyroid biopsy has no role in the diagnosis of NTI.

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Histologic Findings

No typical histological findings of thyroid biopsies in NTI exist.

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Staging

No established clinical staging of NTI exists; abnormalities of thyroid function test findings are proportional to the severity and duration of NTI.

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