Insomnia Differential Diagnoses

Updated: Nov 27, 2017
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Diagnostic Considerations

Disorders to consider in the differential diagnosis of insomnia include the following:

  • Central sleep apnea (primary or due to drug or substance)
  • Cheyne-Stokes breathing pattern (associated with heart failure)
  • High-altitude periodic breathing
  • Jet-lag disorder
  • Medication-related insomnia

Medications associated with insomnia are as follows:

  • Central nervous system stimulants (dextroamphetamine, methylphenidate)
  • Antihypertensives (alpha blockers, beta blockers)
  • Respiratory medications (albuterol, theophylline)
  • Decongestants (phenylephrine, pseudoephedrine)
  • Hormones (corticosteroids, thyroid medications)
  • Antiepileptic drugs (lamotrigine)
  • Other noncontrolled substances (caffeine, alcohol, nicotine)

Differential Diagnoses