Toxic Anterior Segment Syndrome (TASS) Workup

Updated: Oct 05, 2021
  • Author: Jean Deschênes, MD, FRCSC; Chief Editor: John D Sheppard, Jr, MD, MMSc  more...
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Laboratory Studies

Patients who present with toxic anterior segment syndrome (TASS) should be assessed carefully, and infectious endophthalmitis should be ruled out. [1, 2]

If at all unclear as to the exact etiology, the protocol for infectious endophthalmitis should be performed. This protocol includes performing an anterior chamber aspirate, a vitreous tap, and/or a vitreous biopsy for Gram stains and microbiologic cultures.

The US Food and Drug Administration's (FDA's) Center for Devices and Radiological Health staff has embarked on a number of projects to mitigate medical device–related TASS outbreaks. These include conducting animal studies to explore various etiologies of TASS, capturing the clinical information necessary to assist investigations of potential future outbreaks, and partnering with the US Centers for Disease Control and Prevention to facilitate a potential TASS investigation, including expediting the analysis of potentially contaminated medical devices. [5]


Imaging Studies

The vitreous should be examined carefully to rule out vitritis. A B-scan ultrasound may be needed if the view is obscured by corneal edema and/or anterior chamber inflammation.