G6PD Deficiency in the Newborn Questions & Answers

Updated: Jun 25, 2020
  • Author: Lawrence C Wolfe, MD; Chief Editor: George T Griffing, MD  more...
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Questions & Answers

Overview

What is glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What are the signs and symptoms of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which semi-quantitative tests are performed in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

How is G6PD activity assessed in workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

How is glucose-6-phosphate dehydrogenase (G6PD) deficiency diagnosed?

How is glucose-6-phosphate dehydrogenase (G6PD) deficiency treated?

How is glucose-6-phosphate dehydrogenase (G6PD) deficiency treated in a neonate?

What is the pathophysiology of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the pathophysiology of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What causes jaundice in neonates with glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What causes glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What causes glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What are the variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

How does the WHO classify the variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

How is glucose-6-phosphate dehydrogenase (G6PD) deficiency classified?

What is the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the US prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the global prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the global prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which patient groups have the highest prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the racial predilection of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the sexual predilection of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the prognosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the prognosis for glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is included in patient education about glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is included in patient education about glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Presentation

Which clinical history findings are characteristic of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which clinical history findings are characteristic of glucose-6-phosphate dehydrogenase (G6PD) deficiency-related neonatal jaundice?

Which clinical history findings are characteristic of glucose-6-phosphate dehydrogenase (G6PD) deficiency-related acute hemolytic anemia?

Which clinical history findings suggest glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What are the signs and symptoms of glucose-6-phosphate dehydrogenase (G6PD) deficiency in neonates?

What are the signs and symptoms of acute hemolytic anemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What are the signs and symptoms of chronic nonspherocytic hemolytic anemia (CNSHA) in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which clinical history findings are characteristic of glucose-6-phosphate dehydrogenase (G6PD) deficiency-related chronic nonspherocytic hemolytic anemia?

Which physical findings are characteristic of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which physical examination findings are characteristic of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

DDX

What are the differential diagnoses for G6PD Deficiency in the Newborn?

Workup

What are indications for testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency?

When is glucose-6-phosphate dehydrogenase (G6PD) deficiency testing indicated?

What is the role of lab testing in the diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the role of a fluorescent spot test in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the role of the methemoglobin reduction test in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the role of the cytofluorimetric method in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the role of spectrophotometric assay in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which semi-quantitative tests are performed in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What are the British Society for Haematology guidelines on glucose-6-phosphate dehydrogenase (G6PD) deficiency testing?

What is the role of spectrophotometric assays in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What are the indications for glucose-6-phosphate dehydrogenase (G6PD) deficiency screening, and what are the guidelines for laboratory testing from the British Society for Haematology?

What is the role of genetic testing in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

When is screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency indicated?

What is the role of imaging studies in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the role of genetic testing in the workup of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Treatment

How is glucose-6-phosphate dehydrogenase (G6PD) deficiency treated?

How is glucose-6-phosphate dehydrogenase (G6PD) deficiency treated in neonates?

How is glucose-6-phosphate dehydrogenase (G6PD) deficiency treated?

How is anemia treated in glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the role of vaccination in the treatment of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What are potential future treatments for glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the role of surgery in the treatment of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

What is the role of surgery in the treatment of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which specialist consultations are beneficial to patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which specialist consultations are beneficial to patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Which dietary modifications are used in the treatment of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

How is glucose-6-phosphate dehydrogenase (G6PD) deficiency prevented?

Guidelines

What are the British Society for Haematology guidelines on the laboratory diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Medications

What is the role of medications in the treatment of glucose-6-phosphate dehydrogenase (G6PD) deficiency?