Granular Corneal Dystrophy Workup

Updated: May 02, 2018
  • Author: Jean Deschênes, MD, FRCSC; Chief Editor: Hampton Roy, Sr, MD  more...
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Corneal biopsy, which is not clinically indicated in patients with granular corneal dystrophy (GCD), reveals eosinophilic hyaline deposits in corneal stroma. When a corneal transplant is performed, the specimen is submitted for histopathologic evaluation

Optical coherence tomography (OCT) has been used in assessing granular corneal dystrophy [13] and has been used to guide phototherapeutic keratectomy (PTK). [14, 15, 16]


Histologic Findings

When corneal specimens are obtained, light microscopy reveals eosinophilic hyaline deposits in the corneal stroma; the source of hyaline material is still unknown.

Masson trichrome stains the deposits bright red.

Pathologic deposits react with antibodies to keratoepithelin. [2]