Superior Limbic Keratoconjunctivitis (SLK) Medication

Updated: Oct 27, 2017
  • Author: Jean Deschênes, MD, FRCSC; Chief Editor: Hampton Roy, Sr, MD  more...
  • Print
Medication

Medication Summary

Mast cell stabilizers and vitamin A preparations have been used with moderate success in the treatment of superior limbic keratoconjunctivitis (SLK). However, these approaches usually offer only temporary mitigation of symptoms, and more definitive treatments are often required. Preservative-free artificial tears may also be helpful.

Topical cyclosporine A has been shown to provide symptom relief and to improve the signs of superior limbic keratoconjunctivitis; however, maintenance therapy is required for continued benefit. [36]

Next:

Mast Cell Stabilizers

Class Summary

Mast cell stabilizers inhibit type 1 immediate hypersensitivity reactions and are used for the long-term inhibition of inflammation.

Lodoxamide tromethamine 0.1% (Alomide)

Lodoxamide is a mast cell stabilizer with reported efficacy in the treatment of superior limbic keratoconjunctivitis.

Cromolyn sodium, ophthalmic (Crolom, Opticrom)

Cromolyn is another mast cell stabilizer with reported efficacy in the treatment of superior limbic keratoconjunctivitis.

Previous
Next:

Cauterizing Agents

Class Summary

Topical application of cauterizing agents is used for the treatment of keratinized conjunctivae.

Silver nitrate

An application of silver nitrate to the anesthetized conjunctiva usually relieves symptoms of superior limbic keratoconjunctivitis for 4-6 weeks. Then, the treatment can be repeated safely.

Previous
Next:

Immunomodulators

Class Summary

Immunomodulatory agents modulate key factors of the immune system.

Cyclosporine A, 0.05% topical (Restasis)

Cyclosporine A is used to relieve dry eyes caused by suppressed tear production secondary to ocular inflammation. This agent is thought to act as a partial immunomodulator, but its exact mechanism of action is not known.

Previous