Band Keratopathy Medication

Updated: Oct 01, 2018
  • Author: Michael Taravella, MD; Chief Editor: John D Sheppard, Jr, MD, MMSc  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce plasma calcium levels, to prevent complications, and to reduce morbidity. As previously mentioned, 0.05 mol, 1.5% neutral disodium EDTA can be applied to the corneal surface to aid in superficial debridement for band keratopathy. Weck-cel sponges soaked in this solution can be used for this purpose, or the solution can be placed in a water bath over the cornea to limit ocular exposure. After debridement, the eye should be thoroughly irrigated to remove EDTA solution from the conjunctival surface and fornices.

Lee et al (2018) described another source of EDTA for use in the treatment of band keratopathy. Dipotassium-EDTA (K2-EDTA) is often used in blood draw tubes; EDTA can be obtained by rinsing these tubes with balanced salt solution and collecting the fluid. Calcific band keratopathy has been successfully treated using this solution. [17]

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Chelating agents

Class Summary

Some agents in this drug category can lower serum calcium levels.

Edetate calcium disodium

This compound chelates with many divalent and trivalent metals. Because of its affinity for calcium, it lowers serum calcium levels during intravenous (IV) infusion. Slow infusion causes mobilization of extracirculatory calcium stores. Edetate calcium disodium also chelates with other polyvalent metals, therefore increasing urinary excretion of magnesium, zinc, and other trace elements. Although it does not chelate with potassium, it may reduce the serum potassium level. Do not use this medication for lead toxicity.

Edentate calcium disodium is indicated for the emergency treatment of hypercalcemia but is rarely used, since newer drugs are now available to treat this indication. It must be specially compounded and buffered for topical formulation. This medication is not indicated for the treatment of band keratopathy or recovery after superficial or lamellar keratectomy.

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