Neurotrophic Keratopathy Medication

Updated: Jun 14, 2016
  • Author: Robert H Graham, MD; Chief Editor: Hampton Roy, Sr, MD  more...
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Medication

Medication Summary

No medications are available that can improve corneal sensitivity. The medications used in the treatment of neurotrophic keratopathy, including antibiotics and cycloplegics, are adjunctive to lubrication and surgical intervention. The number and types of medications vary according to the disease stage.

Future treatments [22] for neurotrophic keratopathy may include the following:

  • Nerve growth factor - Has been shown to induce healing of stage 3 keratopathy in an open, uncontrolled study [23, 24, 25]
  • Aldose reductase inhibitor, CT-112 - Has been shown to reverse abnormal morphology of corneal epithelial cells and to increase corneal sensitivity [26]
  • Topical pindolol - Has been reported to speed the healing of epithelial defects in rabbits
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Antibiotics

Class Summary

The tetracyclines have shown anti-inflammatory and anticollagenolytic activity.

Tetracycline

Tetracycline may have anticollagenolytic properties that improve symptoms.

Doxycycline (Doryx, Vibramycin, Alodox, Adoxa)

This agent also may have anticollagenolytic properties that improve symptoms.

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Cycloplegics/Mydriatics

Class Summary

These agents relieve pain associated with iridocyclitis.

Atropine ophthalmic (Isopto, Atropine Care)

This agent acts at parasympathetic sites in smooth muscle to block the response of the sphincter muscle of the iris and the muscle of the ciliary body to acetylcholine, causing mydriasis and cycloplegia.

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Ophthalmic Lubricants

Class Summary

The goal of a lubricant is to keep as much moisture in the eye as possible and to reduce irritation. [27]

Artificial tears (Advanced Eye Relief, Murine, Bion Tears, Tears Again, Tears Naturale)

Artificial tears contain the equivalent of 0.9% NaCl and are used to maintain ocular tonicity. They stabilize and thicken precorneal tear film and prolong tear film breakup time, which occurs with dry eye states.

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