Corneal Ulcer Questions & Answers

1. Gurnani B, Kaur K. Bacterial Keratitis. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].

2. Byrd LB, Martin N. Corneal Ulcer. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].

3. Shinomiya K, Ueta M, Sotozono C, Inatomi T, Yokoi N, Koizumi N, et al. Immunohistochemical analysis of inflammatory limbal conjunctiva adjacent to Mooren's ulcer. Br J Ophthalmol. 2013 Mar. 97 (3):362-6. [QxMD MEDLINE Link].

4. Kafkala C, Choi J, Zafirakis P, Baltatzis S, Livir-Rallatos C, Rojas B, et al. Mooren ulcer: an immunopathologic study. Cornea. 2006 Jul. 25 (6):667-73. [QxMD MEDLINE Link].

5. Hardy S, Hashemi K, Catanese M, Candil M, Zufferey P, Gabison E, et al. Necrotising Scleritis and Peripheral Ulcerative Keratitis Associated with Rheumatoid Arthritis Treated with Rituximab. Klin Monbl Augenheilkd. 2017 Apr. 234 (4):567-570. [QxMD MEDLINE Link].

6. Lee HJ, Kim MK, Wee WR, Oh JY. Interplay of Immune Cells in Mooren Ulcer. Cornea. 2015 Sep. 34 (9):1164-7. [QxMD MEDLINE Link].

7. Zelefsky JR, Srinivasan M, Kundu A, Lietman T, Whitcher JP, Wang K, et al. Hookworm infestation as a risk factor for Mooren's ulcer in South India. Ophthalmology. 2007 Mar. 114 (3):450-3. [QxMD MEDLINE Link].

8. Srinivasan M, Zegans ME, Zelefsky JR, Kundu A, Lietman T, Whitcher JP, et al. Clinical characteristics of Mooren's ulcer in South India. Br J Ophthalmol. 2007 May. 91 (5):570-5. [QxMD MEDLINE Link].

9. Wilson SE, Lee WM, Murakami C, Weng J, Moninger GA. Mooren-type hepatitis C virus-associated corneal ulceration. Ophthalmology. 1994 Apr. 101(4):736-45. [QxMD MEDLINE Link].

10. Jain AK, Sukhija J, Saini JS, Chawla Y, Dhiman RK. Hepatitis C virus-associated keratitis. Eye (Lond). 2004 Feb. 18 (2):131-4. [QxMD MEDLINE Link].

11. Wang QS, Yuan J, Zhou SY, Chen JQ. Chronic hepatitis C virus infection is not associated with Mooren's ulcer. Eye (Lond). 2008 May. 22 (5):697-700. [QxMD MEDLINE Link].

12. Knox Cartwright NE, Tole DM, Georgoudis P, Cook SD. Peripheral ulcerative keratitis and corneal melt: a 10-year single center review with historical comparison. Cornea. 2014 Jan. 33 (1):27-31. [QxMD MEDLINE Link].

13. Dong Y, Zhang Y, Xie L, Ren J. Risk Factors, Clinical Features, and Treatment Outcomes of Recurrent Mooren Ulcers in China. Cornea. 2017 Feb. 36 (2):202-209. [QxMD MEDLINE Link].

14. Sainz de la Maza M, Foster CS, Jabbur NS, Baltatzis S. Ocular characteristics and disease associations in scleritis-associated peripheral keratopathy. Arch Ophthalmol. 2002 Jan. 120 (1):15-9. [QxMD MEDLINE Link].

15. Turesson C, Jacobsson L, Bergström U. Extra-articular rheumatoid arthritis: prevalence and mortality. Rheumatology (Oxford). 1999 Jul. 38 (7):668-74. [QxMD MEDLINE Link].

16. McGavin DD, Williamson J, Forrester JV, Foulds WS, Buchanan WW, Dick WC, et al. Episcleritis and scleritis. A study of their clinical manifestations and association with rheumatoid arthritis. Br J Ophthalmol. 1976 Mar. 60 (3):192-226. [QxMD MEDLINE Link].

17. Foster CS, Forstot SL, Wilson LA. Mortality rate in rheumatoid arthritis patients developing necrotizing scleritis or peripheral ulcerative keratitis. Effects of systemic immunosuppression. Ophthalmology. 1984 Oct. 91 (10):1253-63. [QxMD MEDLINE Link].

18. Stylianides A, Jones MN, Stewart RM, Murphy CC, Goodson NJ, Kaye SB. Rheumatoid arthritis-associated corneal ulceration: mortality and graft survival. Ophthalmology. 2013 Apr. 120 (4):682-6. [QxMD MEDLINE Link].

19. Ladas JG, Mondino BJ. Systemic disorders associated with peripheral corneal ulceration. Curr Opin Ophthalmol. 2000 Dec. 11 (6):468-71. [QxMD MEDLINE Link].

20. Murray PI, Rauz S. The eye and inflammatory rheumatic diseases: The eye and rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis. Best Pract Res Clin Rheumatol. 2016 Oct. 30 (5):802-825. [QxMD MEDLINE Link].

21. Ahmed M, Niffenegger JH, Jakobiec FA, Ben-Arie-Weintrob Y, Gion N, Androudi S, et al. Diagnosis of limited ophthalmic Wegener granulomatosis: distinctive pathologic features with ANCA test confirmation. Int Ophthalmol. 2008 Feb. 28 (1):35-46. [QxMD MEDLINE Link].

22. Harthan JS, Reeder RE. Peripheral ulcerative keratitis in association with sarcoidosis. Cont Lens Anterior Eye. 2013 Dec. 36 (6):313-7. [QxMD MEDLINE Link].

23. Silpa-archa S, Lee JJ, Foster CS. Ocular manifestations in systemic lupus erythematosus. Br J Ophthalmol. 2016 Jan. 100 (1):135-41. [QxMD MEDLINE Link].

24. Levitt AE, McManus KT, McClellan AL, Davis JL, Goldhardt R, Galor A. Ocular Inflammation in the Setting of Concomitant Systemic Autoimmune Conditions in an Older Male Population. Cornea. 2015 Jul. 34 (7):762-7. [QxMD MEDLINE Link].

25. Siracuse-Lee D, Saffra N. Peripheral ulcerative keratitis in sarcoidosis: a case report. Cornea. 2006 Jun. 25 (5):618-20. [QxMD MEDLINE Link].

26. Ji YS, Yoon KC. A rare case of peripheral ulcerative keratitis associated with Behçet's disease. Int Ophthalmol. 2014 Aug. 34 (4):979-81. [QxMD MEDLINE Link].

27. Lai THT, Far N, Young AL, Jhanji V. Rapid corneal thinning and perforated ulcerative keratitis in a patient with relapsing polychondritis. Eye Vis (Lond). 2017. 4:8. [QxMD MEDLINE Link].

28. Paroli MP, Pinca M, Speranza S, Marino M, Pivetti-Pezzi P. Paracentral corneal melting in a patient with Vogt-Koyanagi-Harada's syndrome, psoriasis, and Hashimoto's thyroiditis. Ocul Immunol Inflamm. 2003 Dec. 11(4):309-13. [QxMD MEDLINE Link].

29. Wei DW, Pagnoux C, Chan CC. Peripheral Ulcerative Keratitis Secondary to Chronic Hepatitis B Infection. Cornea. 2017 Apr. 36 (4):515-517. [QxMD MEDLINE Link].

30. Asai T, Nakagami T, Mochizuki M. Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug. Cornea. 2006 Feb. 25 (2):224-7. [QxMD MEDLINE Link].

31. Flach AJ. Corneal melts associated with topically applied nonsteroidal anti-inflammatory drugs. Trans Am Ophthalmol Soc. 2001. 99:205-10; discussion 210-2. [QxMD MEDLINE Link].

32. Guidera AC, Luchs JI, Udell IJ. Keratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs. Ophthalmology. 2001 May. 108(5):936-44. [QxMD MEDLINE Link].

33. Lambiase A, Bonini S, Aloe L, et al. Anti-inflammatory and healing properties of nerve growth factor in immune corneal ulcers with stromal melting. Arch Ophthalmol. 2000 Oct. 118(10):1446-9. [QxMD MEDLINE Link].

34. Troumani Y, Beral L, Glatre F, Finke E, David T. [One case of corneal melting after instillation of bromfenac 0.09%]. J Fr Ophtalmol. 2014 Oct. 37 (8):e125-7. [QxMD MEDLINE Link].

35. Schechter BA, Rand WJ, Nagler RS. Corneal melt after amniotic membrane transplant. Cornea. 2005 Jan. 24(1):106-7. [QxMD MEDLINE Link].

36. Bouhout S, Robert MC, Deli S, Harissi-Dagher M. Corneal Melt after Boston Keratoprosthesis: Clinical Presentation, Management, Outcomes and Risk Factor Analysis. Ocul Immunol Inflamm. 2017 Jan 12. 1-7. [QxMD MEDLINE Link].

37. Yazici AT, Kara N, Yüksel K, Altinkaynak H, Baz O, Bozkurt E, et al. The biomechanical properties of the cornea in patients with systemic lupus erythematosus. Eye (Lond). 2011 Aug. 25(8):1005-9. [QxMD MEDLINE Link]. [Full Text].

38. Kalsow CM, Ching SS, Plotnik RD. Cellular Infiltrate in Rheumatoid Arthritis-associated Paracentral Corneal Ulceration. Ocul Immunol Inflamm. 2016 Aug 11. 1-6. [QxMD MEDLINE Link].

39. Gomes BA, Santhiago MR, Jorge PA, Kara-José N, Moraes HV Jr, Kara-Junior N. Corneal involvement in systemic inflammatory diseases. Eye Contact Lens. 2015 May. 41 (3):141-4. [QxMD MEDLINE Link].

40. Lambiase A, Rama P, Bonini S, et al. Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med. 1998 Apr 23. 338(17):1174-80. [QxMD MEDLINE Link].

41. Manni L, Rocco ML, Bianchi P, Soligo M, Guaragna M, Barbaro SP, et al. Nerve growth factor: basic studies and possible therapeutic applications. Growth Factors. 2013 Aug. 31 (4):115-22. [QxMD MEDLINE Link].

42. Korsten P, Bahlmann D, Patschan SA. Rapid healing of peripheral ulcerative keratitis in rheumatoid arthritis with prednisone, methotrexate and adalimumab combination therapy. Rheumatology (Oxford). 2017 Feb 14. [QxMD MEDLINE Link].

43. Ebrahimiadib N, Modjtahedi BS, Roohipoor R, Anesi SD, Foster CS. Successful Treatment Strategies in Granulomatosis With Polyangiitis-Associated Peripheral Ulcerative Keratitis. Cornea. 2016 Nov. 35 (11):1459-1465. [QxMD MEDLINE Link].

44. Guindolet D, Reynaud C, Clavel G, Belangé G, Benmahmed M, Doan S, et al. Management of severe and refractory Mooren's ulcers with rituximab. Br J Ophthalmol. 2017 Apr. 101 (4):418-422. [QxMD MEDLINE Link].

45. Vanathi M, Sharma N, Titiyal JS. Tectonic grafts for corneal thinning and perforations. Cornea. 2002 Nov. 21(8):792-7. [QxMD MEDLINE Link].

46. Al Motowa S, Al Zobidi M. Amniotic Membrane Transplant with a Special Technique (Motowa's Sandwich Technique) in Mooren's Ulcer. Middle East Afr J Ophthalmol. 2015 Jul-Sep. 22 (3):386-8. [QxMD MEDLINE Link].

47. Krysik K, Dobrowolski D, Lyssek-Boron A, Jankowska-Szmul J, Wylegala EA. Differences in Surgical Management of Corneal Perforations, Measured over Six Years. J Ophthalmol. 2017. 2017:1582532. [QxMD MEDLINE Link].

48. Rush SW, Rush RB. Outcomes of Infectious versus Sterile Perforated Corneal Ulcers after Therapeutic Penetrating Keratoplasty in the United States. J Ophthalmol. 2016. 2016:6284595. [QxMD MEDLINE Link].

Jean Deschênes, MD, FRCSC Professor, Research Associate, Director, Uveitis Program, Department of Ophthalmology, McGill University Faculty of Medicine; Senior Ophthalmologist, Clinical Director, Department of Ophthalmology, Royal Victoria Hospital, Canada

Jean Deschênes, MD, FRCSC is a member of the following medical societies: American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, Canadian Medical Association, Canadian Ophthalmological Society, International Ocular Inflammation Society, Quebec Medical Association

Disclosure: Nothing to disclose.

Susan Ruyu Qi University of Montreal Faculty of Medicine, Canada

Disclosure: Nothing to disclose.

Angela Maria Fajardo Palomino, MD Fellow in Cornea, External Disease and Uveitis, McGill University Faculty of Medicine, Canada

Disclosure: Nothing to disclose.

Simon K Law, MD, PharmD Clinical Professor of Health Sciences, Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, David Geffen School of Medicine

Simon K Law, MD, PharmD is a member of the following medical societies: American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, American Glaucoma Society

Disclosure: Nothing to disclose.

J James Rowsey, MD Former Director of Corneal Services, St Luke's Cataract and Laser Institute

J James Rowsey, MD is a member of the following medical societies: American Academy of Ophthalmology, American Association for the Advancement of Science, American Medical Association, Association for Research in Vision and Ophthalmology, Florida Medical Association, Sigma Xi, The Scientific Research Honor Society, Southern Medical Association, Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Hampton Roy, Sr, MD † Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences

Hampton Roy, Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Fernando H Murillo-Lopez, MD Senior Surgeon, Unidad Privada de Oftalmologia CEMES

Fernando H Murillo-Lopez, MD is a member of the following medical societies: American Academy of Ophthalmology

Disclosure: Nothing to disclose.

Kilbourn Gordon, III, MD, FACEP Urgent Care Physician

Kilbourn Gordon, III, MD, FACEP is a member of the following medical societies: American Academy of Ophthalmology, Wilderness Medical Society

Disclosure: Nothing to disclose.

• Print this section
• Print the entire contents of
• Print the entire contents of article