Descemet Membrane Folds Medication

Updated: Apr 30, 2021
  • Author: Robert H Graham, MD; Chief Editor: Hampton Roy, Sr, MD  more...
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Medication

Medication Summary

Medical treatment of Descemet folds requires the treatment of the underlying cause of ocular inflammation. This includes topical steroidal, nonsteroidal, and osmotic agents, as well as topical antibiotics, as needed, for ocular infection. [6] Once the underlying ocular inflammation is treated, the Descemet folds generally resolve.

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Corticosteroid

Class Summary

Inhibit edema, fibrin deposition, capillary dilation and proliferation, and deposition of collagen and scar formation.

Prednisolone (Pred Forte, Pred Mild, Omnipred)

Decreases inflammation and corneal neovascularization. Suppresses migration of polymorphonuclear leukocytes and reverses increased capillary permeability.

In cases of bacterial infections, concomitant use of anti-infective agents is mandatory; if signs and symptoms do not improve after 2 days, re-evaluate patient. Dosing may be reduced, but advise patients not to discontinue therapy prematurely.

Sold under multiple preparations and suspensions.

Loteprednol (Lotemax, Alrex)

Structurally similar to other corticosteroids but with a variation that enhances penetration into cells, transforms into inactive metabolite quickly. This drug is less likely than prednisolone acetate to increase intraocular pressure with prolonged use.

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Nonsteroidal ophthalmic drops

Class Summary

Used to decrease corneal inflammation.

Bromfenac ophthalmic (BromSite, Prolensa)

Nonsteroidal anti-inflammatory eyedrops, by inhibiting cyclooxygenase and thus prostaglandin synthesis, have analgesic, anti-inflammatory, and antipyretic properties. 

Ketorolac tromethamine (Acular, Acuvail)

Member of nonsteroidal anti-inflammatory drugs for ophthalmic use. Has analgesic, anti-inflammatory, and antipyretic properties and also inhibits prostaglandin biosynthesis.

Diclofenac ophthalmic (Voltaren)

A phenylacetic acid with anti-inflammatory and analgesic properties. Believed to inhibit cyclooxygenase, essential to the synthesis of prostaglandins.

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Hypertonic agents

Class Summary

Sodium chloride hypertonic ophthalmic solution used to dehydrate the cornea.

Sodium chloride hypertonic, ophthalmic (Muro 128, Altachlore, Sochlor)

Used for temporary relief of corneal edema. Available as 2% and 5% ophthalmic solution concentrations and 5% ointment. The 5% drop is typically the concentration used.

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