Posterior Polymorphous Corneal Dystrophy Differential Diagnoses

1. Koeppe L. Klinische Beobachtungen mit der Nerstspaltlampe und dem Hornhautmikroskop. Albrecht von Graefe's Arch Klin Exp Ophthalmol. 1916. 91:375-379.

2. Liskova P, Gwilliam R, Filipec M, Jirsova K, Reinstein Merjava S, Deloukas P, et al. High prevalence of posterior polymorphous corneal dystrophy in the czech republic; linkage disequilibrium mapping and dating an ancestral mutation. PLoS One. 2012. 7(9):e45495. [QxMD MEDLINE Link]. [Full Text].

3. Ahn YJ, Choi SI, Yum HR, Shin SY, Park SH. Clinical Features in Children with Posterior Polymorphous Corneal Dystrophy. Optom Vis Sci. 2017 Apr. 94 (4):476-481. [QxMD MEDLINE Link].

4. Liskova P, Palos M, Hardcastle AJ, Vincent AL. Further genetic and clinical insights of posterior polymorphous corneal dystrophy 3. JAMA Ophthalmol. 2013 Oct. 131(10):1296-303. [QxMD MEDLINE Link].

5. Bakhtiari P, Frausto RF, Roldan AN, Wang C, Yu F, Aldave AJ. Exclusion of pathogenic promoter region variants and identification of novel nonsense mutations in the zinc finger E-box binding homeobox 1 gene in posterior polymorphous corneal dystrophy. Mol Vis. 2013. 19:575-80. [QxMD MEDLINE Link]. [Full Text].

6. Liskova P, Dudakova L, Evans CJ, Rojas Lopez KE, Pontikos N, Athanasiou D, et al. Ectopic GRHL2 Expression Due to Non-coding Mutations Promotes Cell State Transition and Causes Posterior Polymorphous Corneal Dystrophy 4. Am J Hum Genet. 2018 Mar 1. 102 (3):447-459. [QxMD MEDLINE Link]. [Full Text].

7. Bozkurt B, Irkec M, Mocan MC. In vivo confocal microscopic findings in posterior polymorphous corneal dystrophy. Cornea. 2013 Sep. 32(9):1237-42. [QxMD MEDLINE Link].

8. Shiraishi A, Zheng X, Sakane Y, Hara Y, Hayashi Y. In vivo confocal microscopic observations of eyes diagnosed with posterior corneal vesicles. Jpn J Ophthalmol. 2016 Nov. 60 (6):425-432. [QxMD MEDLINE Link].

9. Bromley JG, Randleman JB, Stone D, Stulting RD, Grossniklaus HE. Clinicopathologic findings in iridocorneal endothelial syndrome and posterior polymorphous membranous dystrophy after Descemet stripping automated endothelial keratoplasty. Cornea. 2012 Sep. 31(9):1060-4. [QxMD MEDLINE Link].

10. Studeny P, Jirsova K, Kuchynka P, Liskova P. Descemet membrane endothelial keratoplasty with a stromal rim in the treatment of posterior polymorphous corneal dystrophy. Indian J Ophthalmol. 2012 Jan-Feb. 60(1):59-60. [QxMD MEDLINE Link].

11. Merjava S, Malinova E, Liskova P, Filipec M, Zemanova Z, Michalova K, et al. Recurrence of posterior polymorphous corneal dystrophy is caused by the overgrowth of the original diseased host endothelium. Histochem Cell Biol. 2011 Jul. 136(1):93-101. [QxMD MEDLINE Link].

12. Moshirfar M, Barsam CA, Tanner MC. Laser in situ keratomileusis in patients with posterior polymorphous dystrophy. Cornea. 2005 Mar. 24(2):230-2. [QxMD MEDLINE Link].

13. Todo et al. Photorefractive keratectomy in posterior polymorphous dystrophy; abstract presented at ASCRS 2010. [Full Text].

14. Anderson NJ, Badawi DY, Grossniklaus HE, Stulting RD. Posterior polymorphous membranous dystrophy with overlapping features of iridocorneal endothelial syndrome. Arch Ophthalmol. 2001 Apr. 119(4):624-5. [QxMD MEDLINE Link].

15. Bechara SJ, Grossniklaus HE, Waring GO, Wells JA 3rd. Keratoconus associated with posterior polymorphous dystrophy. Am J Ophthalmol. 1991 Dec 15. 112(6):729-31. [QxMD MEDLINE Link].

16. Boruchoff SA, Weiner MJ, Albert DM. Recurrence of posterior polymorphous corneal dystrophy after penetrating keratoplasty. Am J Ophthalmol. 1990 Mar 15. 109(3):323-8. [QxMD MEDLINE Link].

17. Brooks AM, Grant G, Gillies WE. Differentiation of posterior polymorphous dystrophy from other posterior corneal opacities by specular microscopy. Ophthalmology. 1989 Nov. 96(11):1639-45. [QxMD MEDLINE Link].

18. Chiou AG, Kaufman SC, Beuerman RW, et al. Confocal microscopy in posterior polymorphous corneal dystrophy. Ophthalmologica. 1999. 213(4):211-3. [QxMD MEDLINE Link].

19. Colville DJ, Savige J. Alport syndrome. A review of the ocular manifestations. Ophthalmic Genet. 1997 Dec. 18(4):161-73. [QxMD MEDLINE Link].

20. Krachmer, Mannis, Holland, eds. Cornea. 1997. Volume II: 1063-73.

21. Grupcheva CN, Chew GS, Edwards M, et al. Imaging posterior polymorphous corneal dystrophy by in vivo confocal microscopy. Clin Experiment Ophthalmol. 2001 Aug. 29(4):256-9. [QxMD MEDLINE Link].

22. Henriquez AS, Kenyon KR, Dohlman CH, et al. Morphologic characteristics of posterior polymorphous dystrophy. A study of nine corneas and review of the literature. Surv Ophthalmol. 1984 Sep-Oct. 29(2):139-47. [QxMD MEDLINE Link].

23. Klintworth GK. The molecular genetics of the corneal dystrophies--current status. Front Biosci. 2003 May 1. 8:d687-713. [QxMD MEDLINE Link].

24. Krachmer JH. Posterior polymorphous corneal dystrophy: a disease characterized by epithelial-like endothelial cells which influence management and prognosis. Trans Am Ophthalmol Soc. 1985. 83:413-75. [QxMD MEDLINE Link].

25. Laganowski HC, Sherrard ES, Muir MG, Buckley RJ. Distinguishing features of the iridocorneal endothelial syndrome and posterior polymorphous dystrophy: value of endothelial specular microscopy. Br J Ophthalmol. 1991 Apr. 75(4):212-6. [QxMD MEDLINE Link].

26. Moroi SE, Gokhale PA, Schteingart MT, et al. Clinicopathologic correlation and genetic analysis in a case of posterior polymorphous corneal dystrophy. Am J Ophthalmol. 2003 Apr. 135(4):461-70. [QxMD MEDLINE Link].

27. Presberg SE, Quigley HA, Forster RK, Green WR. Posterior polymorphous corneal dystrophy. Cornea. 1985-86. 4(4):239-48. [QxMD MEDLINE Link].

28. Teekhasaenee C, Nimmanit S, Wutthiphan S, et al. Posterior polymorphous dystrophy and Alport syndrome. Ophthalmology. 1991 Aug. 98(8):1207-15. [QxMD MEDLINE Link].

29. Weissman BA, Ehrlich M, Levenson JE, Pettit TH. Four cases of keratoconus and posterior polymorphous corneal dystrophy. Optom Vis Sci. 1989 Apr. 66(4):243-6. [QxMD MEDLINE Link].

30. Salman, Mohd MSc*, †; Verma, Anshuman PhD*, ‡; Singh, Vijay Kumar PhD*; Jaffet, et al. New Frontier in the Management of Corneal Dystrophies: Basics, Development, and Challenges in Corneal Gene Therapy and Gene Editing. Asia-Pacific Journal of Ophthalmology. July/August 2022. 11(4):346-359. [Full Text].

Mark Ventocilla, OD, FAAO Chief Executive Officer, Elder Eye Care Group, PLC; Chief Executive Officer, Mark Ventocilla, OD, Inc; President, California Eye Wear, Oakwood Optical

Mark Ventocilla, OD, FAAO is a member of the following medical societies: American Academy of Optometry, American Optometric Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Christopher J Rapuano, MD Professor, Department of Ophthalmology, Sidney Kimmel Medical College of Thomas Jefferson University; Director of the Cornea Service, Wills Eye Hospital

Christopher J Rapuano, MD is a member of the following medical societies: American Academy of Ophthalmology, American Ophthalmological Society, American Society of Cataract and Refractive Surgery, Contact Lens Association of Ophthalmologists, Cornea Society, Eye Bank Association of America, International Society of Refractive Surgery

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: AAO; OMIC; American Society of Ophthalmic Trauma (ASOT); Avellino, Baxis; Bio-Tissue; Celularity; Dompe; Emmecell; Glaukos; Kala; Oyster Point; Sun Ophthalmics; Tarsus; TearLab<br/>Serve(d) as a speaker or a member of a speakers bureau for: Glaukos; Dompe; Bio-Tissue<br/>Received research grant from: Glaukos<br/>Received income in an amount equal to or greater than $250 from: AAO; OMIC; Baxis; Bio-Tissue; Cellularity; Dompe; Glaukos; Kala; Sun Ophthalmics; TearLab<br/>stock options for: RPS, Fount Bio.

Hampton Roy, Sr, MD † Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences

Hampton Roy, Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Fernando H Murillo-Lopez, MD Senior Surgeon, Unidad Privada de Oftalmologia CEMES

Fernando H Murillo-Lopez, MD is a member of the following medical societies: American Academy of Ophthalmology

Disclosure: Nothing to disclose.

Dustin J Coupal, MD, FRCSC Eye Specialist and Surgeon, Private Practice

Dustin J Coupal, MD, FRCSC is a member of the following medical societies: American Academy of Ophthalmology, Canadian Medical Association, Canadian Medical Protective Association, and Canadian Ophthalmological Society

Disclosure: Nothing to disclose.

W Keith Hamilton, MD Clinical Assistant Professor, Department of Ophthalmology, Saskatoon City Hospital Eye Centre

Disclosure: Nothing to disclose.

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