Pituitary Apoplexy Medication

Updated: Jun 03, 2022
  • Author: Michael S Vaphiades, DO; Chief Editor: Edsel B Ing, MD, PhD, MBA, MEd, MPH, MA, FRCSC  more...
  • Print

Medication Summary

As corticotropic deficiency is present in most patients with pituitary apoplexy and may be life-threatening, [26] the goals of pharmacotherapy are to correct the corticosteroid deficiency, to reduce morbidity, and to prevent complications.  

In one study, 84% of patients developed one or more anterior pituitary hormone deficiency, 74% were diagnosed with severe growth hormone deficiency, and 68% required long-term steroid replacement. Sixty-five percent were deficient in both thyroxine and also gonadotrophin. No patients had long-term diabetes insipidus. Overall, the rates of hypopituitarism at follow-up were similar between the emergency surgical, elective surgical, and the conservative treatment groups [45] .



Class Summary

Corticosteroids replenish the cortisol that would normally be produced under this type of physiologic stressful situation.

Hydrocortisone (Hydrocortone, Cortef, Solu-Cortef)

Hydrocortisone decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability.