Bacterial Endophthalmitis Medication

1. Davis JL. Diagnostic dilemmas in retinitis and endophthalmitis. Eye (Lond). 2012 Feb. 26(2):194-201. [QxMD MEDLINE Link]. [Full Text].

2. Forster RK. Etiology and diagnosis of bacterial postoperative endophthalmitis. Ophthalmology. 1978 Apr. 85(4):320-6. [QxMD MEDLINE Link].

3. Arshinoff SA, Bastianelli PA. Incidence of postoperative endophthalmitis after immediate sequential bilateral cataract surgery. J Cataract Refract Surg. 2011 Dec. 37(12):2105-14. [QxMD MEDLINE Link].

4. Thompson JT, Parver LM, Enger CL, Mieler WF, Liggett PE. Infectious endophthalmitis after penetrating injuries with retained intraocular foreign bodies. National Eye Trauma System. Ophthalmology. 1993 Oct. 100(10):1468-74. [QxMD MEDLINE Link].

5. Irvine WD, Flynn HW Jr, Murray TG, Rubsamen PE. Retained lens fragments after phacoemulsification manifesting as marked intraocular inflammation with hypopyon. Am J Ophthalmol. 1992 Nov 15. 114(5):610-4. [QxMD MEDLINE Link].

6. Packer AJ, Weingeist TA, Abrams GW. Retinal periphlebitis as an early sign of bacterial endophthalmitis. Am J Ophthalmol. 1983 Jul. 96(1):66-71. [QxMD MEDLINE Link].

7. Mieler WF, Ellis MK, Williams DF, Han DP. Retained intraocular foreign bodies and endophthalmitis. Ophthalmology. 1990 Nov. 97(11):1532-8. [QxMD MEDLINE Link].

8. Okada AA, Johnson RP, Liles WC, D'Amico DJ, Baker AS. Endogenous bacterial endophthalmitis. Report of a ten-year retrospective study. Ophthalmology. 1994 May. 101(5):832-8. [QxMD MEDLINE Link].

9. Donahue SP, Kowalski RP, Jewart BH, Friberg TR. Vitreous cultures in suspected endophthalmitis. Biopsy or vitrectomy?. Ophthalmology. 1993 Apr. 100(4):452-5. [QxMD MEDLINE Link].

10. Hariprasad SM, Shah GK, Chi J, Prince RA. Determination of aqueous and vitreous concentration of moxifloxacin 0.5% after delivery via a dissolvable corneal collagen shield device. J Cataract Refract Surg. 2005 Nov. 31(11):2142-6. [QxMD MEDLINE Link].

11. Chiquet C, Cornut PL, Benito Y, et al. Eubacterial PCR for bacterial detection and identification in 100 acute postcataract surgery endophthalmitis. Invest Ophthalmol Vis Sci. 2008 May. 49(5):1971-8. [QxMD MEDLINE Link].

12. Chan IM, Jalkh AE, Trempe CL, Tolentino FI. Ultrasonographic findings in endophthalmitis. Ann Ophthalmol. 1984 Aug. 16(8):778-84. [QxMD MEDLINE Link].

13. Callegan MC, Gilmore MS, Gregory M, et al. Bacterial endophthalmitis: therapeutic challenges and host-pathogen interactions. Prog Retin Eye Res. 2007 Mar. 26(2):189-203. [QxMD MEDLINE Link].

14. Garat M, Moser CL, Alonso-Tarres C, Martin-Baranera M, Alberdi A. Intracameral cefazolin to prevent endophthalmitis in cataract surgery: 3-year retrospective study. J Cataract Refract Surg. 2005 Nov. 31(11):2230-4. [QxMD MEDLINE Link].

15. Flynn HW Jr, Pulido JS, Pflugfelder SC, et al. Endophthalmitis therapy: changing antibiotic sensitivity patterns and current therapeutic recommendations. Arch Ophthalmol. 1991 Feb. 109(2):175-6. [QxMD MEDLINE Link].

16. Costello P, Bakri SJ, Beer PM, et al. Vitreous penetration of topical moxifloxacin and gatifloxacin in humans. Retina. 2006 Feb. 26(2):191-5. [QxMD MEDLINE Link].

17. Gan IM, Ugahary LC, van Dissel JT, et al. Intravitreal dexamethasone as adjuvant in the treatment of postoperative endophthalmitis: a prospective randomized trial. Graefes Arch Clin Exp Ophthalmol. 2005 Dec. 243(12):1200-5. [QxMD MEDLINE Link].

18. Smiddy WE, Smiddy RJ, Ba'Arath B, et al. Subconjunctival antibiotics in the treatment of endophthalmitis managed without vitrectomy. Retina. 2005 Sep. 25(6):751-8. [QxMD MEDLINE Link].

19. Assaad D, Wong D, Mikhail M, Tawfik S, Altomare F, Berger A, et al. Bacterial endophthalmitis: 10-year review of the culture and sensitivity patterns of bacterial isolates. Can J Ophthalmol. 2015 Dec. 50 (6):433-7. [QxMD MEDLINE Link].

20. Ahmed S, Kuruvilla O, Yee DC, Aggarwal H, Li Y, Edwards P, et al. Intraocular penetration of systemic antibiotics in eyes with penetrating ocular injury. J Ocul Pharmacol Ther. 2014 Dec. 30 (10):823-30. [QxMD MEDLINE Link].

21. Miller JJ, Scott IU, Flynn HW Jr, Smiddy WE, Newton J, Miller D. Acute-onset endophthalmitis after cataract surgery (2000-2004): incidence, clinical settings, and visual acuity outcomes after treatment. Am J Ophthalmol. 2005 Jun. 139(6):983-7. [QxMD MEDLINE Link].

22. Creuzot-Garcher CP, Mariet AS, Benzenine E, Daien V, Korobelnik JF, Bron AM, et al. Is combined cataract surgery associated with acute postoperative endophthalmitis? A nationwide study from 2005 to 2014. Br J Ophthalmol. 2018 Jun 20. [QxMD MEDLINE Link].

23. Deramo VA, Lai JC, Winokur J, Luchs J, Udell IJ. Visual outcome and bacterial sensitivity after methicillin-resistant Staphylococcus aureus-associated acute endophthalmitis. Am J Ophthalmol. 2008 Mar. 145(3):413-417. [QxMD MEDLINE Link].

24. Mandelbaum S, Forster RK, Gelender H, Culbertson W. Late onset endophthalmitis associated with filtering blebs. Ophthalmology. 1985 Jul. 92(7):964-72. [QxMD MEDLINE Link].

25. Hariprasad SM, Shah GK, Mieler WF, et al. Vitreous and aqueous penetration of orally administered moxifloxacin in humans. Arch Ophthalmol. 2006 Feb. 124(2):178-82. [QxMD MEDLINE Link].

26. Zapp D, Loos D, Feucht N, Khoramnia R, Tandogan T, Reznicek L, et al. Microbial keratitis-induced endophthalmitis: incidence, symptoms, therapy, visual prognosis and outcomes. BMC Ophthalmol. 2018 May 3. 18 (1):112. [QxMD MEDLINE Link].

27. Lau PE, Jenkins KS, Layton CJ. Current Evidence for the Prevention of Endophthalmitis in Anti-VEGF Intravitreal Injections. J Ophthalmol. 2018. 2018:8567912. [QxMD MEDLINE Link].

28. Gregory M, Callegan MC, Gilmore MS. Role of bacterial and host factors in infectious endophthalmitis. Chem Immunol Allergy. 2007. 92:266-75. [QxMD MEDLINE Link].

29. Kunimoto DY, Das T, Sharma S, et al. Microbiologic spectrum and susceptibility of isolates: part I. Postoperative endophthalmitis. Endophthalmitis Research Group. Am J Ophthalmol. 1999 Aug. 128(2):240-2. [QxMD MEDLINE Link].

30. Rathinam SR, Rao NA. Sympathetic ophthalmia following postoperative bacterial endophthalmitis: a clinicopathologic study. Am J Ophthalmol. 2006 Mar. 141(3):498-507. [QxMD MEDLINE Link].

31. Somani S, Grinbaum A, Slomovic AR. Postoperative endophthalmitis: incidence, predisposing surgery, clinical course and outcome. Can J Ophthalmol. 1997 Aug. 32(5):303-10. [QxMD MEDLINE Link].

32. Winward KE, Pflugfelder SC, Flynn HW Jr, Roussel TJ, Davis JL. Postoperative Propionibacterium endophthalmitis. Treatment strategies and long-term results. Ophthalmology. 1993 Apr. 100(4):447-51. [QxMD MEDLINE Link].

33. Greenfield DS, Suner IJ, Miller MP, Kangas TA, Palmberg PF, Flynn HW Jr. Endophthalmitis after filtering surgery with mitomycin. Arch Ophthalmol. 1996 Aug. 114(8):943-9. [QxMD MEDLINE Link].

34. Bouza E, Grant S, Jordan C, Yook RH, Sulit HL. Bacillus cereus endogenous panophthalmitis. Arch Ophthalmol. 1979 Mar. 97(3):498-9. [QxMD MEDLINE Link].

35. Soheilian M, Rafati N, Mohebbi MR, et al. Prophylaxis of acute posttraumatic bacterial endophthalmitis: a multicenter, randomized clinical trial of intraocular antibiotic injection, report 2. Arch Ophthalmol. 2007 Apr. 125(4):460-5. [QxMD MEDLINE Link].

36. Sjoholm-Gomez de Liano C, Soberon-Ventura VF, Salcedo-Villanueva G, Santos-Palacios A, Guerrero-Naranjo JL, Fromow-Guerra J, et al. Sensitivity, specificity and predictive values of anterior chamber tap in cases of bacterial endophthalmitis. Eye Vis (Lond). 2017. 4:18. [QxMD MEDLINE Link].

37. Abrishami M, Hashemi B, Abrishami M, Abnous K, Razavi-Azarkhiavi K, Behravan J. PCR detection and identification of bacterial contaminants in ocular samples from post-operative endophthalmitis. J Clin Diagn Res. 2015 Apr. 9 (4):NC01-3. [QxMD MEDLINE Link].

38. Aaberg TM Jr, Flynn HW Jr, Schiffman J, Newton J. Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes. Ophthalmology. 1998 Jun. 105(6):1004-10. [QxMD MEDLINE Link].

39. Barza M, Pavan PR, Doft BH, et al. Evaluation of microbiological diagnostic techniques in postoperative endophthalmitis in the Endophthalmitis Vitrectomy Study. Arch Ophthalmol. 1997 Sep. 115(9):1142-50. [QxMD MEDLINE Link].

40. Cohen SM, Flynn HW Jr, Murray TG, Smiddy WE. Endophthalmitis after pars plana vitrectomy. The Postvitrectomy Endophthalmitis Study Group. Ophthalmology. 1995 May. 102(5):705-12. [QxMD MEDLINE Link].

41. Endophthalmitis Vitrectomy Study Group. Results of the Endophthalmitis Vitrectomy Study. A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Endophthalmitis Vitrectomy Study Group. Arch Ophthalmol. 1995 Dec. 113(12):1479-96. [QxMD MEDLINE Link].

42. Han DP, Wisniewski SR, Wilson LA, et al. Spectrum and susceptibilities of microbiologic isolates in the Endophthalmitis Vitrectomy Study. Am J Ophthalmol. 1996 Jul. 122(1):1-17. [QxMD MEDLINE Link].

43. Ng JQ, Morlet N, Pearman JW, et al. Management and outcomes of postoperative endophthalmitis since the endophthalmitis vitrectomy study: the Endophthalmitis Population Study of Western Australia (EPSWA)'s fifth report. Ophthalmology. 2005 Jul. 112(7):1199-206. [QxMD MEDLINE Link].

44. Storey P, Dollin M, Rayess N, Pitcher J, Reddy S, Vander J, et al. The effect of prophylactic topical antibiotics on bacterial resistance patterns in endophthalmitis following intravitreal injection. Graefes Arch Clin Exp Ophthalmol. 2016 Feb. 254 (2):235-42. [QxMD MEDLINE Link].

45. Gupta A, Orlans HO, Hornby SJ, Bowler IC. Microbiology and visual outcomes of culture-positive bacterial endophthalmitis in Oxford, UK. Graefes Arch Clin Exp Ophthalmol. 2014 Nov. 252 (11):1825-30. [QxMD MEDLINE Link].

46. Kodati S, Eller AW, Kowalski RP. The Susceptibility of Bacterial Endophthalmitis Isolates to Vancomycin, Ceftazidime, and Amikacin: a 23 Year-Review. Ophthalmol Retina. 2017 May-Jun. 1 (3):206-209. [QxMD MEDLINE Link].

47. Zhang YQ, Wang WJ. Treatment outcomes after pars plana vitrectomy for endogenous endophthalmitis. Retina. 2005 Sep. 25(6):746-50. [QxMD MEDLINE Link].

48. van Kooij B, Rothova A, de Vries P. The pros and cons of intravitreal triamcinolone injections for uveitis and inflammatory cystoid macular edema. Ocul Immunol Inflamm. 2006 Apr. 14(2):73-85. [QxMD MEDLINE Link].

49. Kowalski RP, Romanowski EG, Mah FS, Yates KA, Gordon YJ. Intracameral Vigamox (moxifloxacin 0.5%) is non-toxic and effective in preventing endophthalmitis in a rabbit model. Am J Ophthalmol. 2005 Sep. 140(3):497-504. [QxMD MEDLINE Link].

50. Alfonso E, Crider J. Ophthalmic infections and their anti-infective challenges. Surv Ophthalmol. 2005 Nov. 50 Suppl 1:S1-6. [QxMD MEDLINE Link].

51. Ayata A, Uzun G, Unal M, Yildiz S, Bilge AH. Does hyperbaric oxygen therapy improve outcome in bacterial endophthalmitis?. Med Hypotheses. 2008 Sep. 71(3):470-1. [QxMD MEDLINE Link].

52. Boggs W. Bacterial Virulence Predicts Visual Prognosis in Post-Op Bacterial Endophthalmitis. Available at http://www.medscape.com/viewarticle/808786. Accessed: August 15, 2013.

53. Combey de Lambert A, Campolmi N, Cornut PL, Aptel F, Creuzot-Garcher C, Chiquet C. Baseline Factors Predictive of Visual Prognosis in Acute Postoperative Bacterial Endophthalmitis in Patients Undergoing Cataract Surgery. JAMA Ophthalmol. 2013 Jul 25. [QxMD MEDLINE Link].

54. Iyer MN, He F, Wensel TG, Mieler WF, Benz MS, Holz ER. Clearance of intravitreal moxifloxacin. Invest Ophthalmol Vis Sci. 2006 Jan. 47(1):317-9. [QxMD MEDLINE Link].

55. Katz HR, Masket S, Lane SS, et al. Absorption of topical moxifloxacin ophthalmic solution into human aqueous humor. Cornea. 2005 Nov. 24(8):955-8. [QxMD MEDLINE Link].

56. Mamalis N, Edelhauser HF, Dawson DG, Chew J, LeBoyer RM, Werner L. Toxic anterior segment syndrome. J Cataract Refract Surg. 2006 Feb. 32(2):324-33. [QxMD MEDLINE Link].

57. Prydal JI, Jenkins DR, Lovering A, Watts A. The pharmacokinetics of linezolid in the non-inflamed human eye. Br J Ophthalmol. 2005 Nov. 89(11):1418-9. [QxMD MEDLINE Link].

58. Suzuki T, Uno T, Kawamura Y, Joko T, Ohashi Y. Postoperative low-grade endophthalmitis caused by biofilm-producing coccus bacteria attached to posterior surface of intraocular lens. J Cataract Refract Surg. 2005 Oct. 31(10):2019-20. [QxMD MEDLINE Link].

59. Wolner B, Liebmann JM, Sassani JW, Ritch R, Speaker M, Marmor M. Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. Ophthalmology. 1991 Jul. 98(7):1053-60. [QxMD MEDLINE Link].

Robert H Graham, MD Consultant, Department of Ophthalmology, Mayo Clinic, Scottsdale, Arizona

Robert H Graham, MD is a member of the following medical societies: American Academy of Ophthalmology, Arizona Ophthalmological Society, American Medical Association

Disclosure: Partner received salary from Medscape/WebMD for employment.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

R Christopher Walton, MD Adjunct Professor, Department of Ophthalmology, University of Texas Health Science Center at San Antonio

R Christopher Walton, MD is a member of the following medical societies: American Academy of Ophthalmology, American Uveitis Society

Disclosure: Nothing to disclose.

Hampton Roy, Sr, MD † Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences

Hampton Roy, Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Andrew W Lawton, MD Neuro-Ophthalmology, Ochsner Health Services

Andrew W Lawton, MD is a member of the following medical societies: American Academy of Ophthalmology, Arkansas Medical Society, Southern Medical Association

Disclosure: Nothing to disclose.

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous coauthors, David T Wong, MD, FRCS(C), and Hesham Lakosha, MBChB, MS, FRCS, to the development and writing of this article.

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