Ophthalmologic Manifestations of Botulism Medication

Updated: May 19, 2016
  • Author: Bhupendra C K Patel, MD, FRCS; Chief Editor: Hampton Roy, Sr, MD  more...
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Medication

Medication Summary

Antitoxin appears to be the only effective medication. Guanethidine has been used and shown to be not effective, despite reports of improvement in accommodative paresis.

In infant botulism, intravenous therapy with botulism immune globulin (BIG), which was approved by the US Food and Drug Administration (FDA) in 2003, is recommended to shorten the duration and to diminish the potential complications.

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Antitoxins

Class Summary

Trivalent (types A, B, and E) equine botulism antitoxin should be used in the presence of food-borne botulism.

Botulinum antitoxin

Intravenous administration of one vial of botulism antitoxin results in serum levels of type A, B, and E antibodies capable of neutralizing serum toxin concentrations in excess of those reported for botulism patients. Circulating antitoxins have a half-life of 5-8 days.

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