Posner-Schlossman Syndrome (PSS) (Glaucomatocyclitic Crisis) Workup

Updated: May 18, 2020
  • Author: Leonard K Seibold, MD; Chief Editor: Hampton Roy, Sr, MD  more...
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Imaging Studies

Digital infrared iris photography may yield informative image patterns. [37]



Perform gonioscopy to rule out closed-angle glaucoma.

Consider anterior chamber paracentesis and aqueous sampling to evaluate for CMV infection.


Histologic Findings

Microscopic examination of trabeculectomy specimens taken at the time of an acute attack reveals inflammation with an abundant mononuclear cell infiltration of the trabecular meshwork.

KPs seen in the setting on CMV endotheliitis are often medium-sized and coin-shaped lesions. On confocal microscopy of these lesions, the classic “owl eye cells” named for large endothelial cells containing nuclei of high reflection surrounded by a halo of low reflection are visible. [38]