Laboratory Studies

Laboratory investigation should be tailored to appropriate studies based on both the history and the physical findings and may include serology and/or skin tests.

Imaging Studies

See the list below:

Chest radiography
Computerized tomography
Magnetic resonance imaging
Gallium scanning

Ocular imaging studies, including anterior-segment optical coherence tomography (OCT) and ultrasound biomicroscopy, are used to identify possible causes of inflammation and to understand the extent of structural changes caused by inflammation. Optic nerve imaging studies and visual field tests are useful to evaluate the stage of glaucoma and to plan appropriate treatment.

Procedures

See the list below:

Conjunctival biopsy
Vitreous biopsy
Anterior chamber paracentesis

Treatment & Management

Hoskins DH, Hetherington J, Shaffer RN. Surgical management of the inflammatory glaucomas. Perspect Ophthalmol. 1977. 1:173-81.
Hill RA, Nguyen QH, Baerveldt G, et al. Trabeculectomy and Molteno implantation for glaucomas associated with uveitis. Ophthalmology. 1993 Jun. 100(6):903-8. [QxMD MEDLINE Link].
Wright MM, McGehee RF, Pederson JE. Intraoperative mitomycin-C for glaucoma associated with ocular inflammation. Ophthalmic Surg Lasers. 1997 May. 28(5):370-6. [QxMD MEDLINE Link].
Hill RA, Heuer DK, Baerveldt G, et al. Molteno implantation for glaucoma in young patients. Ophthalmology. 1991 Jul. 98(7):1042-6. [QxMD MEDLINE Link].
Ceballos EM, Parrish RK, Schiffman JC. Outcome of Baerveldt glaucoma drainage implants for the treatment of uveitic glaucoma. Ophthalmology. 2002 Dec. 109(12):2256-60. [QxMD MEDLINE Link].
Ozdal PC, Vianna RN, Deschenes J. Ahmed valve implantation in glaucoma secondary to chronic uveitis. Eye. 2006 Feb. 20(2):178-83. [QxMD MEDLINE Link].
Rachmiel R, Trope GE, Buys YM, Flanagan JG, Chipman ML. Ahmed glaucoma valve implantation in uveitic glaucoma versus open-angle glaucoma patients. Can J Ophthalmol. 2008 Aug. 43(4):462-7. [QxMD MEDLINE Link].
Callanan DG, Jaffe GJ, Martin DF, Pearson PA, Comstock TL. Treatment of posterior uveitis with a fluocinolone acetonide implant: three-year clinical trial results. Arch Ophthalmol. 2008 Sep. 126(9):1191-201. [QxMD MEDLINE Link].
Bollinger K, Kim J, Lowder CY, Kaiser PK, Smith SD. Intraocular pressure outcome of patients with fluocinolone acetonide intravitreal implant for noninfectious uveitis. Ophthalmology. 2011 Oct. 118(10):1927-31. [QxMD MEDLINE Link].
Hunter RS, Lobo AM. Dexamethasone intravitreal implant for the treatment of noninfectious uveitis. Clin Ophthalmol. 2011. 5:1613-21. [QxMD MEDLINE Link].
Lowder C, Belfort R Jr, Lightman S, Foster CS, Robinson MR, Schiffman RM, et al. Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. Arch Ophthalmol. 2011 May. 129 (5):545-53. [QxMD MEDLINE Link].
Jaffe GJ, Foster CS, Pavesio CE, Paggiarino DA, Riedel GE. Effect of an Injectable Fluocinolone Acetonide Insert on Recurrence Rates in Chronic Noninfectious Uveitis Affecting the Posterior Segment: Twelve-Month Results. Ophthalmology. 2019 Apr. 126 (4):601-610. [QxMD MEDLINE Link].
Almobarak FA, Alharbi AH, Morales J, Aljadaan I. Intermediate and Long-term Outcomes of Mitomycin C-enhanced Trabeculectomy as a First Glaucoma Procedure in Uveitic Glaucoma. J Glaucoma. 2017 Feb 23. [QxMD MEDLINE Link].
Dhanireddy S, Kombo NC, Payal AR, Freitas-Neto CA, Preble J, Foster CS. The Ex-PRESS Glaucoma Filtration Device Implantation in Uveitic Glaucoma. Ocul Immunol Inflamm. 2016 May 26. [QxMD MEDLINE Link].
Malone PE, Herndon LW, Muir KW, Jaffe GJ. Combined fluocinolone acetonide intravitreal insertion and glaucoma drainage device placement for chronic uveitis and glaucoma. Am J Ophthalmol. 2010 May. 149(5):800-6.e1. [QxMD MEDLINE Link].
Zivney M, Lin P, Edmunds B, Parikh M, Takusagawa H, Tehrani S. Combined Glaucoma TUbe Shunt (Ahmed) and Fluocinolone Acetonide (Retisert) Implantation Compared to Ahmed Alone in Uveitic Glaucoma. Ophthalmol Ther. 2016 Dec. 5:223-233. [QxMD MEDLINE Link]. [Full Text].
Hennein L, Hou J, Stewart JM, Lowry EA, Jiang Z, Enanoria WT, et al. Comparison of Surgical Outcome After Ahmed Valve Implantation for Patients With and Without Fluocinolone Intravitreal Implant (Retisert). J Glaucoma. 2016 Sep. 25:[QxMD MEDLINE Link]. [Full Text].
Chow A, Burkemper B, Varma R, Rodger DC, Rao N, Richter GM. Comparison of surgical outcomes of trabeculectomy, Ahmed shunt, and Baerveldt shunt in uveitic glaucoma. J Ophthalmic Inflamm Infect. 2018 Jun 18. 8 (1):9. [QxMD MEDLINE Link].
Horsley MB, Chen TC. The use of prostaglandin analogs in the uveitic patient. Semin Ophthalmol. 2011 Jul-Sep. 26(4-5):285-9. [QxMD MEDLINE Link].
Markomichelakis NN, Kostakou A, Halkiadakis I, Chalkidou S, Papakonstantinou D, Georgopoulos G. Efficacy and safety of latanoprost in eyes with uveitic glaucoma. Graefes Arch Clin Exp Ophthalmol. 2009 Jun. 247(6):775-80. [QxMD MEDLINE Link].

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Author

Leon Herndon, Jr, MD Professor, Department of Ophthalmology, Duke University Medical Center

Leon Herndon, Jr, MD is a member of the following medical societies: American Glaucoma Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: New World Medical; Alcon; Allergan; Glaukos; Aerie<br/>Serve(d) as a speaker or a member of a speakers bureau for: New World Medical<br/>Received research grant from: Ocular Therapeutix<br/>Received income in an amount equal to or greater than $250 from: Glaukos; Allergan; Alcon; New World Medical<br/>Stock options for: Sight Sciences.

Specialty Editor Board

Simon K Law, MD, PharmD Clinical Professor of Health Sciences, Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, David Geffen School of Medicine

Simon K Law, MD, PharmD is a member of the following medical societies: American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, American Glaucoma Society

Disclosure: Nothing to disclose.

Martin B Wax, MD Professor, Department of Ophthalmology, University of Texas Southwestern Medical School; Vice President, Research and Development, Head, Ophthalmology Discovery Research and Preclinical Sciences, Alcon Laboratories, Inc

Martin B Wax, MD is a member of the following medical societies: American Academy of Ophthalmology, American Glaucoma Society, Society for Neuroscience

Disclosure: Nothing to disclose.

Chief Editor

Inci Irak Dersu, MD, MPH Associate Professor of Clinical Ophthalmology, State University of New York Downstate College of Medicine; Attending Physician, SUNY Downstate Medical Center, Kings County Hospital, and VA Harbor Health Care System

Inci Irak Dersu, MD, MPH is a member of the following medical societies: American Academy of Ophthalmology, American Glaucoma Society

Disclosure: Nothing to disclose.

Additional Contributors

Neil T Choplin, MD Adjunct Clinical Professor, Department of Surgery, Section of Ophthalmology, Uniformed Services University of Health Sciences

Neil T Choplin, MD is a member of the following medical societies: American Academy of Ophthalmology, American Glaucoma Society, Association for Research in Vision and Ophthalmology, California Association of Ophthalmology, San Diego County Ophthalmological Society, Society of Military Ophthalmologists

Disclosure: Nothing to disclose.

Uveitic Glaucoma Workup

Laboratory Studies

Imaging Studies

Procedures

References

Tables

Contributor Information and Disclosures

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