Hashimoto Thyroiditis Differential Diagnoses

Updated: Feb 01, 2022
  • Author: Stephanie L Lee, MD, PhD; Chief Editor: George T Griffing, MD  more...
  • Print

Diagnostic Considerations

The following autoimmune phenomena may occur or be found in association with Hashimoto thyroiditis:

  • Addison disease

  • Alopecia areata, totalis, and universalis

  • Autoimmune gastritis (pernicious anemia)

  • Chronic active hepatitis

  • Idiopathic hypoparathyroidism

  • Polymyalgia rheumatica and giant cell arteritis

  • Primary biliary cirrhosis

  • Primary ovarian or testicular failure

  • Rheumatoid arthritis

  • Sjögren syndrome

  • Systemic lupus erythematosus (SLE)

  • Systemic sclerosis (scleroderma)

  • Type 1 diabetes mellitus [24]

  • Vitiligo

A study by Posselt et al found the prevalence of Hashimoto thyroiditis to be 12.6% in patients with SLE, compared with 5.6% in controls. The investigators also found a higher level of anti-Smith antibodies in patients with Hashimoto thyroiditis, but a lower prevalence of malar rash. No relation was found between the presence of Hashimoto disease and cumulative damage from SLE. [25]

Differential Diagnoses