Uveitis, Anterior, Childhood Workup

Updated: Jun 17, 2016
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Hampton Roy, Sr, MD  more...
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Laboratory Studies

If JIA is suspected, obtain an antinuclear antibody test to classify the condition and to determine the risk of recurrent and severe disease.

In patients suspected of having AS, reactive arthritis, or inflammatory bowel disease, perform testing for the HLA-B27 haplotype. Sacroiliac joint films may demonstrate evidence of joint involvement in AS and reactive arthritis.

Sarcoid uveitis is investigated with determination of the angiotensin-converting enzyme (ACE) level, with or without serum lysozyme testing, chest roentgenograms, and gallium scanning. Remember that normal ACE values in children are higher than those in adults. Definitive diagnosis requires histopathologic demonstration of noncaseating granulomatous inflammation, in the absence of another possible cause.

If symptoms suggest TINU, urinalysis, serum creatinine, and urine beta-2-microglubulin testing is indicated.

Antistreptococcal lysin O titers are indicated in patients with possible poststreptococcal syndrome uveitis.