Medication Summary
Topical, oral, or intralesional corticosteroids are used in the treatment of ocular juvenile xanthogranuloma (JXG). Because of risk of spontaneous hemorrhage, all ocular tumors probably should be treated. [13] Specific medications used include the treatments described below.
Corticosteroids, Ophthalmic
Class Summary
Minimize the activity of inflammatory cells and formation of granulomas. Used in symptomatic patients and commonly provides symptomatic improvement.
Prednisolone acetate 1% (Pred Forte)
Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability. DOC for lesions involving the anterior segment.
Prednisolone ophthalmic (Delta-Cortef, Econopred)
Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability. For ocular lesions not responsive to topical steroids.
Dexamethasone ophthalmic (Maxidex)
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Juvenile xanthogranuloma. Photograph of an 18-month-old presenting with a firm, nodular, tan-yellow lesion that has grown since first noticed 6 months ago. An examination under anesthesia did not reveal any ocular abnormalities. Excision of the lesion confirmed that this was a juvenile xanthogranuloma.
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Touton giant cell in juvenile xanthogranuloma. Touton giant cell with a wreath of nuclei surrounding a homogenous eosinophilic cytoplasmic center in juvenile xanthogranuloma. Touton cells are named after Karl Touton, who first described them in 1885. Touton giant cells are seen in xanthoma, juvenile and adult xanthogranulomas, dermatofibroma, and fat necrosis.
