Nasolacrimal Duct Obstruction and Epiphora Differential Diagnoses

1. Linberg JV, McCormick SA. Primary acquired nasolacrimal duct obstruction. A clinicopathologic report and biopsy technique. Ophthalmology. 1986 Aug. 93(8):1055-63. [QxMD MEDLINE Link].

2. Bartley GB. Acquired lacrimal drainage obstruction: an etiologic classification system, case reports, and a review of the literature. Part 1. Ophthal Plast Reconstr Surg. 1992. 8(4):237-42. [QxMD MEDLINE Link].

3. Bartley GB. Acquired lacrimal drainage obstruction: an etiologic classification system, case reports, and a review of the literature. Part 2. Ophthal Plast Reconstr Surg. 1992. 8(4):243-9. [QxMD MEDLINE Link].

4. Bartley GB. Acquired lacrimal drainage obstruction: an etiologic classification system, case reports, and a review of the literature. Part 3. Ophthal Plast Reconstr Surg. 1993. 9(1):11-26. [QxMD MEDLINE Link].

5. Groessl SA, Sires BS, Lemke BN. An anatomical basis for primary acquired nasolacrimal duct obstruction. Arch Ophthalmol. 1997 Jan. 115(1):71-4. [QxMD MEDLINE Link].

6. Kashkonli MB, Rezaee R, Nilforonshan N, et al. Topical antiglaucoma medications and lacrimal drainage system obstruction. Ophthal Plast Reconstr Surg. 2008 May-Jun. 24(3):175-6.

7. Seider N, Miller B, Beiran I. Topical glaucoma therapy as a risk factor for nasolacrimal duct obstruction. Am J Ophthalmol. 2008 Jan. 145(1):120-123. [QxMD MEDLINE Link].

8. Berry-Brincat A, Tomlins P, Hall A, Quinlan M, Cheung D. Primary extrasac orbital lymphoma presenting as nasolacrimal obstruction. Orbit. 2008. 27(3):175-7. [QxMD MEDLINE Link].

9. Yamagishi T, Ochi N, Yamane H, Hasebe S, Takigawa N. Epiphora in lung cancer patients receiving docetaxel: a case series. BMC Res Notes. 2014 May 30. 7:322. [QxMD MEDLINE Link]. [Full Text].

10. Esmaeli B, Hidaji L, Adinin RB, Faustina M, Coats C, Arbuckle R, et al. Blockage of the lacrimal drainage apparatus as a side effect of docetaxel therapy. Cancer. 2003 Aug 1. 98(3):504-7. [QxMD MEDLINE Link].

11. Kashkouli MB, Pakdel F, Hashemi M, Ghaempanah MJ, Rezaee R, Kaghaz-Kanani R, et al. Comparing anatomical pattern of topical anti-glaucoma medications associated lacrimal obstruction with a control group. Orbit. 2010 Apr. 29(2):65-9. [QxMD MEDLINE Link].

12. Alexandrakis G, Tse DT, Rosa RH, Johnson TE. Nasolacrimal duct obstruction associated with chronic intranasal cocaine abuse. Arch Ophthalmic. 1999 Dec. 117(12):1617-22. [QxMD MEDLINE Link].

13. Tanweer F, Mahkamova K, Harkness P. Nasolacrimal duct tumours in the era of endoscopic dacryocystorhinostomy: literature review. J Laryngol Otol. 2013 Jul. 127 (7):670-5. [QxMD MEDLINE Link].

14. Udhay P, Noronha OV, Mohan RE. Helical computed tomographic dacryocystography and its role in the diagnosis and management of lacrimal drainage system blocks and medial canthal masses. Indian J Ophthalmol. 2008 Jan-Feb. 56(1):31-7. [QxMD MEDLINE Link]. [Full Text].

15. Gökçek A, Argin MA, Altintas AK. Comparison of failed and successful dacryocystorhinostomy by using computed tomographic dacryocystography findings. Eur J Ophthalmol. 2005 Sep-Oct. 15(5):523-9. [QxMD MEDLINE Link].

16. Taupin T, Taief Boudrigua Aicha L, Baggio E, Gensburger M, Pialat JB. [Comparison of 3T dacryo-MRI by instillation with dacryo-CT scan for evaluation of epiphora.]. J Fr Ophtalmol. 2014 Jun 24. [QxMD MEDLINE Link].

17. Karagülle T, Erden A, Erden I, Zilelioglu G. Nasolacrimal system: evaluation with gadolinium-enhanced MR dacryocystography with a three-dimensional fast spoiled gradient-recalled technique. Eur Radiol. 2002 Sep. 12(9):2343-8. [QxMD MEDLINE Link].

18. Anderson NG, Wojno TH, Grossniklaus HE. Clinicopathologic findings from lacrimal sac biopsy specimens obtained during dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2003 May. 19(3):173-6. [QxMD MEDLINE Link].

19. Gomez A, Gladstone G. Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. Orbit. 2016 Feb. 35 (1):48-50. [QxMD MEDLINE Link].

20. Daraei P, DelGaudio JM. Inferior Meatus Surgery for Distal Nasolacrimal Duct Obstructions: Long-term Outcomes and Treatment Paradigm. JAMA Otolaryngol Head Neck Surg. 2014 Jun 26. [QxMD MEDLINE Link].

21. Moscato EE, Dolmetsch AM, Silkiss RZ, Seiff SR. Silicone intubation for the treatment of epiphora in adults with presumed functional nasolacrimal duct obstruction. Ophthal Plast Reconstr Surg. 2012 Jan. 28(1):35-9. [QxMD MEDLINE Link].

22. Goldberg RA, Samimi DB, Tsirbas A, Douglas RS. The hydrogel lacrimal stent for dacryocystorhinostomy: preliminary experience. Ophthal Plast Reconstr Surg. 2008 Mar-Apr. 24(2):85-9. [QxMD MEDLINE Link].

23. Baruch B, Sarwagi M, Sahu P, Dubey KP, Gupta A, Kumar A. Polypropylene in Endoscopic Dacryocystorhinostomy: A Novel Stent. Indian J Otolaryngol Head Neck Surg. 2018 June. 70(2):240-243. [QxMD MEDLINE Link].

24. Erkan AN, Yilmazer C, Altan-Yaycioglu R. Otologic T-tube in endonasal dacryocystorhinostomy: a new approach. Acta Otolaryngol. 2007 Dec. 127(12):1316-20. [QxMD MEDLINE Link].

25. Oghan F, Ozcura F. A novel stenting technique in endoscopic dacryocystorhinostomy. Eur Arch Otorhinolaryngol. 2008 Aug. 265(8):911-5. [QxMD MEDLINE Link].

26. Kim KR, Song HY, Shin JH, Kim JH, Choi EK, Lee YJ. Efficacy of mitomycin C irrigation after removal of an occluded nasolacrimal stent. J Vasc Interv Radiol. 2007 Apr. 18(4):519-25. [QxMD MEDLINE Link].

27. Kim KR, Song HY, Shin JH, et al. Eficacy of Mitomycin-C irrigation after balloon dacryoplasty. J Vasc Interv Radiol. 2007 Jun. 18(6):757-62.

28. Nemet AY, Wilcsek G, Francis IC. Endoscopic dacryocystorhinostomy with adjunctive mitomycin C for canalicular obstruction. Orbit. 2007 Jun. 26(2):97-100. [QxMD MEDLINE Link].

29. Tabatabaie SZ, Heirati A, Rajabi MT, Kasaee A. Silicone intubation with intraoperative mitomycin C for nasolacrimal duct obstruction in adults: a prospective, randomized, double-masked study. Ophthal Plast Reconstr Surg. 2007 Nov-Dec. 23(6):455-8. [QxMD MEDLINE Link].

30. Yildirim C, Yaylali V, Esme A, Ozden S. Long-term results of adjunctive use of mitomycin C in external dacryocystorhinostomy. Int Ophthalmol. 2007 Feb. 27(1):31-5. [QxMD MEDLINE Link].

31. Ashenhurst ME, Hill VE, Keyhani K. Restrictive strabismus following Jones tube insertion: a case series of 8 patients. Can J Ophthalmol. 2007 Aug. 42(4):613-6. [QxMD MEDLINE Link].

32. Migliori ME. Endoscopic evaluation and management of the lacrimal sump syndrome. Ophthal Plast Reconstr Surg. 1997 Dec. 13(4):281-4. [QxMD MEDLINE Link].

33. Golub JS, Parikh SL, Budnick SD, Bernardino CR, DelGaudio JM. Inverted papilloma of the nasolacrimal system invading the orbit. Ophthal Plast Reconstr Surg. 2007 Mar-Apr. 23(2):151-3. [QxMD MEDLINE Link].

34. Bajaj MS, Mahindrakar A, Pushker N. Dentigerous cyst in the maxillary sinus: a rare cause of nasolacrimal obstruction. Orbit. 2003 Dec. 22(4):289-92. [QxMD MEDLINE Link].

35. Becelli R, Renzi G, Mannino G, Cerulli G, Iannetti G. Posttraumatic obstruction of lacrimal pathways: a retrospective analysis of 58 consecutive naso-orbitoethmoid fractures. J Craniofac Surg. 2004 Jan. 15(1):29-33. [QxMD MEDLINE Link].

36. Burns JA, Morgenstern KE, Cahill KV, Foster JA, Jhiang SM, Kloos RT. Nasolacrimal obstruction secondary to I(131) therapy. Ophthal Plast Reconstr Surg. 2004 Mar. 20(2):126-9. [QxMD MEDLINE Link].

37. Camara JG, Bengzon AU, Henson RD. The safety and efficacy of mitomycin C in endonasal endoscopic laser-assisted dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2000 Mar. 16(2):114-8. [QxMD MEDLINE Link].

38. Camara JG, Santiago MD. Success rate of endoscopic laser-assisted dacryocystorhinostomy. Ophthalmology. 1999 Mar. 106(3):441-2. [QxMD MEDLINE Link].

39. Camara JG, Santiago MD, Rodriguez RE, Medalle RA, Young DA, Atebara NH. The Micro-Reflux Test: a new test to evaluate nasolacrimal duct obstruction. Ophthalmology. 1999 Dec. 106(12):2319-21. [QxMD MEDLINE Link].

40. Couch SM, White WL. Endoscopically assisted balloon dacryoplasty treatment of incomplete nasolacrimal duct obstruction. Ophthalmology. 2004 Mar. 111(3):585-9. [QxMD MEDLINE Link].

41. de Bree R, Scheeren RA, Kummer A, Tiwari RM. Nasolacrimal duct obstruction caused by an oncocytoma. Rhinology. 2002 Sep. 40(3):165-7. [QxMD MEDLINE Link].

42. Dolman PJ. Comparison of external dacryocystorhinostomy with nonlaser endonasal dacryocystorhinostomy. Ophthalmology. 2003 Jan. 110(1):78-84. [QxMD MEDLINE Link].

43. Esmaeli B, Hidaji L, Adinin RB, et al. Blockage of the lacrimal drainage apparatus as a side effect of docetaxel therapy. Cancer. 2003 Aug 1. 98(3):504-7. [QxMD MEDLINE Link].

44. Esmer O, Karadag R, Soylu E, Oner AF, Burakgazi-Dalkilic E. Nasolacrimal system obstruction, ptosis and esotropia due to chemotherapy in acute lymphoblastic leukemia. Cutan Ocul Toxicol. 2013 Oct. 32(4):330-2. [QxMD MEDLINE Link].

45. Katowitz JA, Low JE. Lacrimal surgery. Duane's Ophthalmology. [book on CD-ROM]; 1998. Vol 5: Chapter 79.

46. Kim N, Park C, Park DJ, Kim HH, Kim S, Kim YJ, et al. Lacrimal drainage obstruction in gastric cancer patients receiving S-1 chemotherapy. Ann Oncol. 2012 Aug. 23(8):2065-71. [QxMD MEDLINE Link].

47. Kloos RT, Duvuuri V, Jhiang SM, Cahill KV, Foster JA, Burns JA. Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma. J Clin Endocrinol Metab. 2002 Dec. 87(12):5817-20. [QxMD MEDLINE Link].

48. Lueder GT. Balloon catheter dilation for treatment of older children with nasolacrimal duct obstruction. Arch Ophthalmol. 2002 Dec. 120(12):1685-8. [QxMD MEDLINE Link].

49. Lueder GT. Endoscopic treatment of intranasal abnormalities associated with nasolacrimal duct obstruction. J AAPOS. 2004 Apr. 8(2):128-32. [QxMD MEDLINE Link].

50. Mauffray RO, Hassan AS, Elner VM. Double silicone intubation as treatment for persistent congenital nasolacrimal duct obstruction. Ophthal Plast Reconstr Surg. 2004 Jan. 20(1):44-9. [QxMD MEDLINE Link].

51. Mirza S, Al-Barmani A, Douglas SA, Bearn MA, Robson AK. A retrospective comparison of endonasal KTP laser dacryocystorhinostomy versus external dacryocystorhinostomy. Clin Otolaryngol Allied Sci. 2002 Oct. 27(5):347-51. [QxMD MEDLINE Link].

52. Nguyen LK, Linberg JV. Evaluation of the lacrimal system. In: Surgery of the eyelid, orbit, and lacrimal system. American Academy of Ophthalmology. 1995. 3:254-69.

53. Oztürk S, Konuk O, Ilgit ET, Unal M, Erdem O. Outcome of patients with nasolacrimal polyurethane stent implantation: do they keep tearing?. Ophthal Plast Reconstr Surg. 2004 Mar. 20(2):130-5. [QxMD MEDLINE Link].

54. Paul L, Pinto I, Vicente JM. Treatment of complete obstruction of the nasolacrimal system by temporary placement of nasolacrimal polyurethane stents: preliminary results. Clin Radiol. 2003 Nov. 58(11):876-82. [QxMD MEDLINE Link].

55. Rogers GA, DelGaudio JM. Inferior meatus dacryolith: an easily managed cause of epiphora. Arch Otolaryngol Head Neck Surg. 2008 Oct. 134(10):1110-1. [QxMD MEDLINE Link].

56. Seider N, Miller B, Beiran I. Topical glaucoma therapy as a risk factor for nasolacrimal duct obstruction. Am J Ophthalmol. 2008 Jan. 145(1):120-123. [QxMD MEDLINE Link].

57. Shepler TR, Sherman SI, Faustina MM, Busaidy NL, Ahmadi MA, Esmaeli B. Nasolacrimal duct obstruction associated with radioactive iodine therapy for thyroid carcinoma. Ophthal Plast Reconstr Surg. 2003 Nov. 19(6):479-81. [QxMD MEDLINE Link].

58. Tao S, Meyer DR, Simon JW, Zobal-Ratner J. Success of balloon catheter dilatation as a primary or secondary procedure for congenital nasolacrimal duct obstruction. Ophthalmology. 2002 Nov. 109(11):2108-11. [QxMD MEDLINE Link].

59. Tsirbas A, Davis G, Wormald PJ. Mechanical endonasal dacryocystorhinostomy versus external dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2004 Jan. 20(1):50-6. [QxMD MEDLINE Link].

60. Tsirbas A, Wormald PJ. Endonasal dacryocystorhinostomy with mucosal flaps. Am J Ophthalmol. 2003 Jan. 135(1):76-83. [QxMD MEDLINE Link].

61. Wobig JL, Dailey RA. Surgery of the Lacrimal System. In: Surgery of the eyelid, orbit, and lacrimal system. American Academy of Ophthalmology. 1995. 3:270-87.

62. Woog JJ, Kennedy RH, Custer PL, Kaltreider SA, Meyer DR, Camara JG. Endonasal dacryocystorhinostomy: a report by the American Academy of Ophthalmology. Ophthalmology. 2001 Dec. 108(12):2369-77. [QxMD MEDLINE Link].

Sandra R Worak, MD Consulting Staff, Department of Orbit and Oculoplasty, Reconstructive and Lacrimal Surgery, East Avenue Medical Center and St Luke's Medical Center

Sandra R Worak, MD is a member of the following medical societies: Philippine Academy of Ophthalmology, Philippine Medical Association

Disclosure: Nothing to disclose.

Alfonso U Bengzon, MD, MBA Consulting Staff, Department of Ophthalmology; Section Head, Section of Oculoplastic and Orbit Surgery, Department of Ophthalmology, The Medical City General Hospital, Philippines; Consultant Head, The Medical City Diagnostic and Laser Eye Center

Alfonso U Bengzon, MD, MBA is a member of the following medical societies: American Academy of Ophthalmology

Disclosure: Nothing to disclose.

Simon K Law, MD, PharmD Clinical Professor of Health Sciences, Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, David Geffen School of Medicine

Simon K Law, MD, PharmD is a member of the following medical societies: American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, American Glaucoma Society

Disclosure: Nothing to disclose.

Hampton Roy, Sr, MD † Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences

Hampton Roy, Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Ron W Pelton, MD, PhD Private Practice, Colorado Springs, Colorado

Ron W Pelton, MD, PhD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, AO Foundation, American Society of Ophthalmic Plastic and Reconstructive Surgery, Colorado Medical Society

Disclosure: Nothing to disclose.

Jorge G Camara, MD Professor of Ophthalmology, Department of Surgery and Director of Fellowship Training Program in Ophthalmic Plastic and Reconstructive Surgery for Countries Served by the Aloha Medical Mission, University of Hawaii John A Burns School of Medicine

Disclosure: Nothing to disclose.

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