Eyelid Papilloma Workup

Updated: Aug 17, 2018
  • Author: Mounir Bashour, MD, PhD, CM, FRCSC, FACS; Chief Editor: Hampton Roy, Sr, MD  more...
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Imaging Studies

Ultrasound biomicroscopy (UBM) at 50 MHz has recently been tried in detecting malignancy of various eyelid lesions and has been shown to have a sensitivity of 78-86% and a specificity of 37-69%; that is, UBM can help differentiate between benign eyelid lesions and malignant eyelid lesions. [1]



Consideration should be given to photographing the lesion.

A biopsy of the lesion may be performed. [2]

Accurate diagnosis of an eyelid lesion requires histologic examination.


Histologic Findings

Usually, squamous papillomas are sessile or pedunculated and have a color similar to the surrounding skin. They often are multiple and tend to involve the lid margin. A small keratin crust often can be palpated on the surface (keratotic papilloma). Microscopically, these lesions are composed of fingerlike projections of vascularized connective tissue covered by hyperplastic epithelium (papillae). The epidermis usually is acanthotic, with elongation of the rete ridges, and shows areas of hyperkeratosis and focal parakeratosis.