High HDL Cholesterol (Hyperalphalipoproteinemia) Questions & Answers

Updated: Aug 06, 2019
  • Author: Basma Abdulhadi, MD; Chief Editor: George T Griffing, MD  more...
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Questions & Answers

Overview

What is the relationship between high-density lipoprotein (HDL) cholesterol and coronary heart disease (CHD)?

What are the major apolipoproteins of high-density lipoprotein (HDL) cholesterol, and what are the associated risks?

How does high-density lipoprotein (HDL) transport cholesterol to the liver?

Is high-density lipoprotein (HDL) cholesterol genetic?

Which environmental factors affect high-density lipoprotein (HDL) cholesterol levels?

Which lipids does a plasma fasting lipid profile measure, and do postprandial blood samples yield accurate results?

What additional testing should be triggered by low high-density lipoprotein (HDL) levels, and when are imaging studies appropriate?

Is medical treatment indicated for high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What causes high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What is the cellular makeup of plasma high-density lipoprotein (HDL)?

How are high-density lipoprotein (HDL) particles classified?

How does high-density lipoprotein (HDL) transfer excess cholesterol from peripheral tissues?

How is cholesterol returned to the liver once picked up by high-density lipoprotein (HDL) from peripheral tissues?

What is the prevalence of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP]) in the US?

What is the global incidence of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

How does high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP]) influence mortality and morbidity?

What is the racial predilection of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Is high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP]) more common in males or females?

What is the prevalence of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP]) among different age groups?

Presentation

Which signs and symptoms suggest high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Which physical findings are associated with high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What causes high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What is familial high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What is primary high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What is the role of cholesteryl ester transfer protein (CETP) deficiency in high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What is the role of lecithin-cholesterol acyltransferase (LCAT) overexpression in high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What is the role of up-regulation of apo A-I production in high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What are secondary causes of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

DDX

What are the differential diagnoses for High HDL Cholesterol (Hyperalphalipoproteinemia)?

Workup

How do the vascular effects of high-density lipoprotein (HDL) vary, and what is the role of a plasma fasting lipid profile in the diagnosis of high HDL cholesterol (hyperalphalipoproteinemia [HALP])?

What is the role of plasma HDL apolipoproteins studies in the diagnosis of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Are imaging studies indicated in the diagnosis of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Other than plasma tests and imaging studies, which studies may be used in the diagnosis of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Are any procedures required in the diagnosis of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Which studies may be performed in patients with multiple lipomatosis syndrome and high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Treatment

When is further evaluation required in high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Is surgery required for high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Are consultations necessary in the treatment of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

What is the role of dietary fat in high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Are any restrictions on physical activity needed for high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?

Medications

Are any medications used in the treatment of high HDL (high-density lipoprotein) cholesterol (hyperalphalipoproteinemia [HALP])?