Medical Care

Most patients with hyperalphalipoproteinemia (HALP) are incidentally diagnosed following blood testing. Generally, patients are asymptomatic and no medical therapy is required. However, patients with corneal opacity may need an evaluation by an ophthalmologist.

Patients in whom excessive alcohol consumption is a cause of elevated high-density lipoprotein cholesterol levels should be assessed for the possible consequences of this practice.

Chest pain syndromes and other manifestations of ischemic heart disease in persons with hyperalphalipoproteinemia must be thoroughly evaluated in the usual manner.

Surgical Care

Surgical care is not usually required.

Consultations

No consultations are usually required.

Diet

Certain forms of dietary therapy, including the consumption of a diet low in fat content, have been shown to influence the levels of alpha lipoproteins and high-density lipoprotein (HDL) cholesterol in plasma. A low-fat diet may cause some reduction in HDL cholesterol levels, while high-fat diets are associated with higher HDL cholesterol levels.

Activity

Most patients with hyperalphalipoproteinemia are healthy and asymptomatic. No restrictions on activity are required.

Medication

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Author

Basma Abdulhadi, MD Fellow, Department of Medicine, Division of Endocrinology, University of Alabama School of Medicine

Basma Abdulhadi, MD is a member of the following medical societies: Alpha Omega Alpha, American Association of Clinical Endocrinologists, Endocrine Society

Disclosure: Nothing to disclose.

Coauthor(s)

Catherine Anastasopoulou, MD, PhD, FACE Associate Professor of Medicine, The Steven, Daniel and Douglas Altman Chair of Endocrinology, Sidney Kimmel Medical College of Thomas Jefferson University; Einstein Endocrine Associates, Einstein Medical Center

Catherine Anastasopoulou, MD, PhD, FACE is a member of the following medical societies: American Association of Clinical Endocrinologists, American Society for Bone and Mineral Research, Endocrine Society, Philadelphia Endocrine Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Don S Schalch, MD Professor Emeritus, Department of Internal Medicine, Division of Endocrinology, University of Wisconsin Hospitals and Clinics

Don S Schalch, MD is a member of the following medical societies: American Diabetes Association, American Federation for Medical Research, Central Society for Clinical and Translational Research, Endocrine Society

Disclosure: Nothing to disclose.

Chief Editor

George T Griffing, MD Professor Emeritus of Medicine, St Louis University School of Medicine

George T Griffing, MD is a member of the following medical societies: American Association for Physician Leadership, American Association for the Advancement of Science, American College of Medical Practice Executives, American College of Physicians, American Diabetes Association, American Federation for Medical Research, American Heart Association, Central Society for Clinical and Translational Research, Endocrine Society, International Society for Clinical Densitometry, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Additional Contributors

Ghassem Pourmotabbed, MD, MD

Ghassem Pourmotabbed, MD, MD is a member of the following medical societies: American Diabetes Association, American Federation for Medical Research, Endocrine Society

Disclosure: Nothing to disclose.

Vibhuti N Singh, MD, MPH, FACC, FSCAI Clinical Assistant Professor, Division of Cardiology, University of South Florida College of Medicine; Director, Cardiology Division and Cardiac Catheterization Lab, Chair, Department of Medicine, Bayfront Medical Center, Bayfront Cardiovascular Associates; President, Suncoast Cardiovascular Research

Vibhuti N Singh, MD, MPH, FACC, FSCAI is a member of the following medical societies: American College of Cardiology, American College of Physicians, American Heart Association, American Medical Association, Florida Medical Association

Disclosure: Nothing to disclose.