Medication Summary
Topical, local, and systemic medications may be useful in the management of various forms of entropion.
Ocular lubricants
Class Summary
Topical ocular lubricants may be necessary to increase patient comfort and to diminish abrasive conjunctivopathy and keratopathy.
Artificial tears
Preservative-free artificial tears are preferred to avoid preservative-associated ocular reactions.
Immunosuppressive agents
Class Summary
These medications have been shown to effectively diminish the autoinflammatory reaction associated with ocular cicatricial pemphigoid.
Dapsone (Avlosulfon)
Bactericidal and bacteriostatic against mycobacteria; mechanism of action is similar to that of sulfonamides where competitive antagonists of PABA prevent formation of folic acid, inhibiting bacterial growth.
Neuromuscular transmission blocking agents
Class Summary
Weakening or paralyzing the orbicularis muscle of the lower eyelid helps in preventing the inturning of the lower eyelid in cases of spastic and involutional entropion.
OnabotulinumtoxinA (BOTOX®)
Temporarily paralyzes the muscles by inhibiting acetylcholine release. Duration of effectiveness usually is 3-4 mo.
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Involutional entropion. Note overriding orbicularis oculi muscle, eyelid margin entropion, and relative enophthalmos with deep superior sulcus.
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Involutional entropion. Correction of entropion with eyelid retractor reattachment and lateral canthopexy.
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Cicatricial entropion of upper eyelid. Note eyelid margin inversion.
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Cicatricial entropion of the upper eyelid with eyelid everted. Note scar tissue involving tarsal conjunctiva.
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Left lower eyelid cicatricial entropion with lower eyelid retraction.
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Left lower eyelid posterior lamellar cicatrix
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Repair of left lower eyelid cicatricial entropion and retraction with cicatrix release and hard-palate mucosal graft.
