Xanthelasma Differential Diagnoses

Updated: Dec 01, 2017
  • Author: Andrew A Dahl, MD, FACS; Chief Editor: Edsel Ing, MD, MPH, FRCSC  more...
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Diagnostic Considerations

Familial hypercholesterolemia types IIa and IIb

Familial dysbetalipoproteinemia type III

Familial hypertriglyceridemia type IV

Other lipid disorders, to include the following:

  • Low HDL cholesterol levels as compared to low-density lipoprotein (LDL) levels
  • Diabetes, uncontrolled with associated hypertriglyceridemia
  • Necrobiotic xanthogranuloma
  • Tuberous xanthomata
  • Diffuse planar xanthoma
  • Orbital lipogranulomata
  • Juvenile xanthogranulomata
  • Erdheim-Chester disease
  • Wegener granulomatosis
  • Lipoid proteinosis
  • Primary systemic amyloidosis
  • Necrobiosis lipoidica
  • Sarcoid
  • Atypical lymphoid infiltrate

Pseudoxanthelasma - One case history describes retinal surgery with silicone oil in tissue mimicking xanthelasma. [3]

Differential Diagnoses