Xanthelasma Differential Diagnoses

Updated: Mar 02, 2021
  • Author: Andrew A Dahl, MD, FACS; Chief Editor: Edsel B Ing, MD, PhD, MBA, MEd, MPH, MA, FRCSC  more...
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Diagnostic Considerations

Familial hypercholesterolemia types IIa and IIb

Familial dysbetalipoproteinemia type III

Familial hypertriglyceridemia type IV

Other lipid disorders, to include the following:

  • Low HDL cholesterol levels as compared to low-density lipoprotein (LDL) levels

  • Diabetes, uncontrolled with associated hypertriglyceridemia

  • Necrobiotic xanthogranuloma

  • Tuberous xanthomata

  • Diffuse planar xanthoma

  • Orbital lipogranulomata

  • Juvenile xanthogranulomata

  • Erdheim-Chester disease

  • Wegener granulomatosis

  • Lipoid proteinosis

  • Primary systemic amyloidosis

  • Necrobiosis lipoidica

  • Sarcoid

  • Atypical lymphoid infiltrate

Pseudoxanthelasma - One case history describes retinal surgery with silicone oil in tissue mimicking xanthelasma. [3]

Differential Diagnoses