Apraxia of Lid Opening Workup

1. Rocha Cabrero F, De Jesus O. Apraxia of Lid Opening. StatPearls. 2023 Jan. [QxMD MEDLINE Link]. [Full Text].

2. Goldstein JE, Cogan DG. Apraxia of Lid Opening. Arch Ophthalmol. 1965 Feb. 73:155-9. [QxMD MEDLINE Link].

3. Geschwind N. The apraxias: neural mechanisms of disorders of learned movement. Am Sci. 1975 Mar-Apr. 63(2):188-95. [QxMD MEDLINE Link].

4. Boghen D. Apraxia of lid opening: a review. Neurology. 1997 Jun. 48(6):1491-4. [QxMD MEDLINE Link].

5. Rucker JC. Normal and abnormal lid function. Handb Clin Neurol. 2011. 102:403-24. [QxMD MEDLINE Link].

6. Rucker JC. Normal and abnormal lid function. Handb Clin Neurol. 2011. 102:403-24. [QxMD MEDLINE Link].

7. Suzuki Y, Kiyosawa M, Mochizuki M, Ishiwata K, Ishii K. The pre-supplementary and primary motor areas generate rhythm for voluntary eye opening and closing movements. Tohoku J Exp Med. 2010. 222(2):97-104. [QxMD MEDLINE Link].

8. Langevin JP, Srikandarajah N, Krahl SE, Gorgulho A, Behnke E, Malkasian D, et al. Eyelid apraxia associated with deep brain stimulation of the periaqueductal gray area. J Clin Neurosci. 2014 Sep. 21(9):1652-3. [QxMD MEDLINE Link].

9. Ugarte M, Teimory M. Apraxia of lid opening. Br J Ophthalmol. 2007 Jul. 91(7):854. [QxMD MEDLINE Link].

10. Jordan DR, Anderson RL, Digre KB. Apraxia of lid opening in blepharospasm. Ophthalmic Surg. 1990 May. 21(5):331-4. [QxMD MEDLINE Link].

11. Krack P, Marion MH. "Apraxia of lid opening," a focal eyelid dystonia: clinical study of 32 patients. Mov Disord. 1994 Nov. 9(6):610-5. [QxMD MEDLINE Link].

12. Hsieh CY, Sung PS, Hwang WJ. Transient blepharospasm, apraxia of eyelid opening, and hemidyskinesia following a right parietotemporal infarct. Parkinsonism Relat Disord. 2014 Sep. 20(9):1024-6. [QxMD MEDLINE Link].

13. Aramideh M, Bour LJ, Koelman JH, Speelman JD, Ongerboer de Visser BW. Abnormal eye movements in blepharospasm and involuntary levator palpebrae inhibition. Clinical and pathophysiological considerations. Brain. 1994 Dec. 117 (Pt 6):1457-74. [QxMD MEDLINE Link].

14. Esteban A, Gimenez-Roldan S. Involuntary closure of eyelids in parkinsonism. Electrophysiological evidence for prolonged inhibition of the levator palpebrae muscles. J Neurol Sci. 1988 Jul. 85(3):333-45. [QxMD MEDLINE Link].

15. Esteban A, Gimenez-Roldan S. [Nociceptive reflex of the orbicularis oculi. Study in normal subjects and in peripheral facial lesions]. Arch Neurobiol (Madr). 1973 Jul-Aug. 36(4):283-94. [QxMD MEDLINE Link].

16. Elston JS. A new variant of blepharospasm. J Neurol Neurosurg Psychiatry. 1992 May. 55(5):369-71. [QxMD MEDLINE Link].

17. Lepore FE, Duvoisin RC. "Apraxia" of eyelid opening: an involuntary levator inhibition. Neurology. 1985 Mar. 35(3):423-7. [QxMD MEDLINE Link].

18. Schmidtke K, Büttner-Ennever JA. Nervous control of eyelid function. A review of clinical, experimental and pathological data. Brain. 1992 Feb. 115 Pt 1:227-47. [QxMD MEDLINE Link].

19. De Renzi E, Gentilini M, Bazolli C. Eyelid movement disorders and motor impersistence in acute hemisphere disease. Neurology. 1986 Mar. 36(3):414-8. [QxMD MEDLINE Link].

20. Smith D, Ishikawa T, Dhawan V, Winterkorn JS, Eidelberg D. Lid opening apraxia is associated with medial frontal hypometabolism. Mov Disord. 1995 May. 10(3):341-4. [QxMD MEDLINE Link].

21. Suzuki Y, Kiyosawa M, Ohno N, Mochizuki M, Inaba A, Mizusawa H, et al. Glucose hypometabolism in medial frontal cortex of patients with apraxia of lid opening. Graefes Arch Clin Exp Ophthalmol. 2003 Jul. 241(7):529-34. [QxMD MEDLINE Link].

22. Dimitriou J, Montoute T, Levivier M, Borruat FX, Diserens K. Bilateral ptosis: Lesion in the oculomotor nuclei or supranuclear lesion?. NeuroRehabilitation. 2015. 36 (3):323-7. [QxMD MEDLINE Link].

23. Micheli F, Cersosimo G, Scorticati MC, Ledesma D, Molinos J. Blepharospasm and apraxia of eyelid opening in lithium intoxication. Clin Neuropharmacol. 1999 May-Jun. 22(3):176-9. [QxMD MEDLINE Link].

24. Tsuji S, Kikkawa S, Horiguchi J, Yamashita H, Kagaya A, Morinobu S, et al. Meige syndrome with apraxia of lid opening after the discontinuation of sulpiride treatment. Pharmacopsychiatry. 2002 Jul. 35(4):155-6. [QxMD MEDLINE Link].

25. Golbe LI, Davis PH, Lepore FE. Eyelid movement abnormalities in progressive supranuclear palsy. Mov Disord. 1989. 4(4):297-302. [QxMD MEDLINE Link].

26. Brusa A, Meneghini S, Piccardo A, Stoehr R. Apraxia of lid opening. Ital J Neurol Sci. 1981 Dec. 2(4):367-70. [QxMD MEDLINE Link].

27. Lee KC, Finley R, Miller B. Apraxia of lid opening: dose-dependent response to carbidopa-levodopa. Pharmacotherapy. 2004 Mar. 24(3):401-3. [QxMD MEDLINE Link].

28. Roh JK, Kim BG, Kim DE, Ahn TB. Apraxia of lid opening associated with hydrocephalus. Eur Neurol. 2001. 45(1):53-4. [QxMD MEDLINE Link].

29. Abe K, Fujimura H, Tatsumi C, Toyooka K, Yorifuji S, Yanagihara T. Eyelid "apraxia" in patients with motor neuron disease. J Neurol Neurosurg Psychiatry. 1995 Dec. 59(6):629-32. [QxMD MEDLINE Link].

30. Bonaventura I, Matias-Guiu J, Cervera C, Codina Puiggros A. Neuroacanthocytosis syndrome, apraxia of eyelid opening, and progressive supranuclear palsy. Neurology. 1986 Sep. 36(9):1276. [QxMD MEDLINE Link].

31. Friedman DI, Jankovic J, McCrary JA 3rd. Neuro-ophthalmic findings in progressive supranuclear palsy. J Clin Neuroophthalmol. 1992 Jun. 12(2):104-9. [QxMD MEDLINE Link].

32. Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science. 1983 Feb 25. 219(4587):979-80. [QxMD MEDLINE Link].

33. Keane JR. Lid-opening apraxia in Wilson's disease. J Clin Neuroophthalmol. 1988 Mar. 8(1):31-3. [QxMD MEDLINE Link].

34. Tolosa E, Martí MJ. Blepharospasm-oromandibular dystonia syndrome (Meige's syndrome): clinical aspects. Adv Neurol. 1988. 49:73-84. [QxMD MEDLINE Link].

35. Nakashima K, Kusumi M, Inoue Y, Takahashi K. Prevalence of focal dystonias in the western area of Tottori Prefecture in Japan. Mov Disord. 1995 Jul. 10(4):440-3. [QxMD MEDLINE Link].

36. Nutt JG, Muenter MD, Melton LJ 3rd, Aronson A, Kurland LT. Epidemiology of dystonia in Rochester, Minnesota. Adv Neurol. 1988. 50:361-5. [QxMD MEDLINE Link].

37. Duffey PO, Butler AG, Hawthorne MR, Barnes MP. The epidemiology of the primary dystonias in the north of England. Adv Neurol. 1998. 78:121-5. [QxMD MEDLINE Link].

38. A prevalence study of primary dystonia in eight European countries. J Neurol. 2000 Oct. 247(10):787-92. [QxMD MEDLINE Link].

39. Defazio G, Livrea P, Lamberti P, De Salvia R, Laddomada G, Giorelli M, et al. Isolated so-called apraxia of eyelid opening: report of 10 cases and a review of the literature. Eur Neurol. 1998. 39(4):204-10. [QxMD MEDLINE Link].

40. Nutt JG. Lid abnormalities secondary to cerebral hemisphere lesions. Ann Neurol. 1977 Feb. 1(2):149-51. [QxMD MEDLINE Link].

41. Lepore FE. So-called apraxias of lid movement. Adv Neurol. 1988. 49:85-90. [QxMD MEDLINE Link].

42. Paus S, Zsurka G, Baron M, Deschauer M, Bamberg C, Klockgether T, et al. Apraxia of lid opening mimicking ptosis in compound heterozygosity for A467T and W748S POLG1 mutations. Mov Disord. 2008 Jul 15. 23(9):1286-8. [QxMD MEDLINE Link].

43. Forget R, Tozlovanu V, Iancu A, Boghen D. Botulinum toxin improves lid opening delays in blepharospasm-associated apraxia of lid opening. Neurology. 2002 Jun 25. 58(12):1843-6. [QxMD MEDLINE Link].

44. Jankovic J. Disease-oriented approach to botulinum toxin use. Toxicon. 2008 Dec 6. [QxMD MEDLINE Link].

45. Yamada S, Matsuo K, Hirayama M, Sobue G. The effects of levodopa on apraxia of lid opening: A case report. Neurology. 2004 Mar 9. 62(5):830-1. [QxMD MEDLINE Link].

46. Dewey RB Jr, Maraganore DM. Isolated eyelid-opening apraxia: report of a new levodopa-responsive syndrome. Neurology. 1994 Sep. 44(9):1752-4. [QxMD MEDLINE Link].

47. Chand RP, Park DM. Atypical blepharospasm responsive to sodium valproate. Mov Disord. 1994 Jan. 9(1):116-7. [QxMD MEDLINE Link].

48. Klostermann W, Vieregge P, Kompf D. Apraxia of eyelid opening after bilateral stereotaxic subthalamotomy. J Neuroophthalmol. 1997 Jun. 17(2):122-3. [QxMD MEDLINE Link].

49. Kerty E, Eidal K. Apraxia of eyelid opening: clinical features and therapy. Eur J Ophthalmol. 2006 Mar-Apr. 16(2):204-8. [QxMD MEDLINE Link].

50. Karapantzou C, Dressler D, Rohrbach S, Laskawi R. Frontalis suspension surgery to treat patients with essential blepharospasm and apraxia of eyelid opening-technique and results. Head Face Med. 2014 Oct 22. 10:44. [QxMD MEDLINE Link].

51. Georgescu D, Vagefi MR, McMullan TF, McCann JD, Anderson RL. Upper eyelid myectomy in blepharospasm with associated apraxia of lid opening. Am J Ophthalmol. 2008 Mar. 145(3):541-547. [QxMD MEDLINE Link].

52. Karapantzou C, Dressler D, Rohrbach S, Laskawi R. Frontalis suspension surgery to treat patients with essential blepharospasm and apraxia of eyelid opening-technique and results. Head Face Med. 2014 Oct 22. 10:44. [QxMD MEDLINE Link].

Marta Ugarte, MBBS, PhD, DPhil, FRCOphth Clinical Medical Retinal Fellow, Moorfields Eye Hospital, UK

Marta Ugarte, MBBS, PhD, DPhil, FRCOphth is a member of the following medical societies: Association for Research in Vision and Ophthalmology, British Medical Association, Royal Society of Medicine, Royal College of Ophthalmologists, International Society of Ocular Trauma

Disclosure: Nothing to disclose.

Hampton Roy, Sr, MD † Associate Clinical Professor, Department of Ophthalmology, University of Arkansas for Medical Sciences

Hampton Roy, Sr, MD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Simon K Law, MD, PharmD Assistant Professor of Ophthalmology, Jules Stein Eye Institute; Chief of Section of Ophthalmology Surgical Services, Department of Veterans Affairs Healthcare Center, West Los Angeles

Simon K Law, MD, PharmD is a member of the following medical societies: American Academy of Ophthalmology, American Glaucoma Society, and Association for Research in Vision and Ophthalmology

Disclosure: Nothing to disclose.

Ron W Pelton, MD, PhD Private Practice, Colorado Springs, Colorado

Ron W Pelton, MD, PhD is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, American Society of Ophthalmic Plastic and Reconstructive Surgery, AO Foundation, and Colorado Medical Society

Disclosure: Nothing to disclose.

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