Blepharochalasis Syndrome Workup

Updated: May 11, 2017
  • Author: Brett S Kotlus, MD, MS; Chief Editor: Hampton Roy, Sr, MD  more...
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Laboratory Studies

The diagnosis of blepharochalasis syndrome is made through clinical history and physical examination.


Imaging Studies

Ultrasonography, CT scanning, or MRI may be performed to exclude dysthyroid orbitopathy, idiopathic orbital inflammation, or other processes that could result in eyelid edema. Imaging may be warranted in individuals with atypical clinical presentations.


Histologic Findings

A biopsy sample of affected skin may reveal immunoglobulin A (IgA) deposits in the dermoepidermal junction with loss of collagen elastic fibers in the dermis. Perivascular inflammatory cells, including lymphocytes, plasma cells, mast cells, histiocytes, and eosinophils, are also present.