Polygenic Hypercholesterolemia Questions & Answers

Updated: Apr 09, 2021
  • Author: Catherine Anastasopoulou, MD, PhD, FACE; Chief Editor: George T Griffing, MD  more...
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Questions & Answers

Overview

What is polygenic hypercholesterolemia?

What is the role of genetics in the etiology of polygenic hypercholesterolemia?

Which organization has published guidelines on the management of polygenic hypercholesterolemia?

What is the pathophysiology of polygenic hypercholesterolemia?

What is the US prevalence of polygenic hypercholesterolemia?

What causes the differences in the prevalence of polygenic hypercholesterolemia among global populations?

Which patient groups have the highest prevalence of polygenic hypercholesterolemia?

What is the prognosis for polygenic hypercholesterolemia?

What is the morbidity and mortality associated with polygenic hypercholesterolemia?

What is included in patient education about polygenic hypercholesterolemia?

Presentation

Which clinical history findings are characteristic of polygenic hypercholesterolemia?

Which physical findings are characteristic of polygenic hypercholesterolemia?

What causes polygenic hypercholesterolemia?

Which risk factors are associated with coronary heart disease in patients with polygenic hypercholesterolemia?

DDX

Which conditions are included in the differential diagnoses of polygenic hypercholesterolemia?

What are the differential diagnoses for Polygenic Hypercholesterolemia?

Workup

Which patients should be screened for polygenic hypercholesterolemia?

Which lab tests are performed in the workup for polygenic hypercholesterolemia?

Treatment

How is polygenic hypercholesterolemia treated?

What are the ACC/AHA guidelines for the treatment of polygenic hypercholesterolemia?

What are the NCEP ATP III guidelines for the treatment of polygenic hypercholesterolemia?

What are the European guidelines for the treatment of polygenic hypercholesterolemia?

How is polygenic hypercholesterolemia treated in patients with type 2 diabetes?

How is polygenic hypercholesterolemia treated in postmenopausal women?

What is the role of simvastatin in the treatment of polygenic hypercholesterolemia?

Which risks are increased in patients with diabetes and polygenic hypercholesterolemia?

What are the treatment goals for patients with diabetes and polygenic hypercholesterolemia?

How is the risk of liver dysfunction managed in patients with polygenic hypercholesterolemia?

How is the risk of myopathy managed in patients with polygenic hypercholesterolemia?

How is statin intolerance managed in patients with polygenic hypercholesterolemia?

Which dietary modifications are used in the treatment of polygenic hypercholesterolemia?

Which activity modifications are used in the treatment of polygenic hypercholesterolemia?

How is polygenic hypercholesterolemia prevented?

What is included in the long-term monitoring of patients with polygenic hypercholesterolemia?

Medications

What is the role of medications in the treatment of polygenic hypercholesterolemia?

Which medications in the drug class PCSK9 Inhibitors are used in the treatment of Polygenic Hypercholesterolemia?

Which medications in the drug class Bile acid sequestrants are used in the treatment of Polygenic Hypercholesterolemia?

Which medications in the drug class Antilipemic agent, fibric acids are used in the treatment of Polygenic Hypercholesterolemia?

Which medications in the drug class Nicotinic Acid are used in the treatment of Polygenic Hypercholesterolemia?

Which medications in the drug class Antilipemic agent, 2-Azetidinone are used in the treatment of Polygenic Hypercholesterolemia?

Which medications in the drug class Antilipemic agent, HMG-COA Reductase Inhibitors are used in the treatment of Polygenic Hypercholesterolemia?