Macular Hole Differential Diagnoses

Updated: Jan 02, 2020
  • Author: Kean Theng Oh, MD; Chief Editor: Douglas R Lazzaro, MD, FAAO, FACS  more...
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Diagnostic Considerations

Pseudohole due to epimacular membrane

Cystoid macular edema

Lamellar macular hole

Vitreomacular traction syndrome

Primary consideration should be given to conditions that may mimic the appearance of a macular hole. While most of these conditions are readily apparent clinically, subtle presentations may present as a macular hole. These conditions include any disease that can cause the development of cystoid macular edema (eg, choroidal neovascularization, retinal vein occlusions, retinitis pigmentosa). An appropriate workup and examination should identify these conditions.

Differential Diagnoses