Eales Disease Medication

Updated: Sep 28, 2018
  • Author: Jonathan C Tsui, MD; Chief Editor: Hampton Roy, Sr, MD  more...
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Medication

Medication Summary

No drugs have been found to be effective in the treatment of the underlying mechanism of Eales disease. Medications used in different studies are mentioned above, but they have not been proven to be beneficial. Cystoid macular edema can complicate Eales disease and has responded to periocular and intravitreal triamcinolone.

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Corticosteroids

Class Summary

Have anti-inflammatory properties and cause profound and varied metabolic effects. Modify the body's immune response to diverse stimuli. Used to stabilize the blood-retinal barrier and to induce resolution of macular edema.

Triamcinolone (Amcort, Kenalog)

For inflammatory dermatosis responsive to steroids; decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. Posterior sub-Tenon injection of steroid to reduce cystoid macular edema. Depending on etiology of edema, it is often DOC.

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Antineoplastic Agent, Monoclonal Antibody

Class Summary

Bevacizumab (Avastin) is a monoclonal antibody that binds to VEGF or vascular endothelial growth factor. It was approved originally in the treatment of colorectal carcinoma. It is now used commonly via intravitreal injection to treat disorders such as exudative macular edema and retinal vein occlusion. Its use has been reported as useful to induce regression of neovascularization in proliferative diabetic retinopathy and would have a similar effect against the neovascularization of Eales disease.

Bevacizumab (Avastin)

Inhibitor of VEGF, a potent mediator of angiogenesis and capillary permeability.

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