Exudative (Wet) Age-Related Macular Degeneration (AMD) Questions & Answers

1. Hobbs SD, Pierce K. Wet Age-related Macular Degeneration (Wet AMD). StatPearls. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].

2. Joachim N, Mitchell P, Burlutsky G, Kifley A, Wang JJ. The Incidence and Progression of Age-Related Macular Degeneration over 15 Years: The Blue Mountains Eye Study. Ophthalmology. 2015 Dec. 122 (12):2482-9. [QxMD MEDLINE Link].

3. Chou R, Dana T, Bougatsos C, Grusing S, Blazina I. Screening for Impaired Visual Acuity in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2016 Mar 1. 315 (9):915-33. [QxMD MEDLINE Link].

4. Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest. 2003 May. 111(9):1287-95. [QxMD MEDLINE Link]. [Full Text].

5. Bradley J, Ju M, Robinson GS. Combination therapy for the treatment of ocular neovascularization. Angiogenesis. 2007. 10(2):141-8. [QxMD MEDLINE Link].

6. Jo N, Mailhos C, Ju M, Cheung E, Bradley J, Nishijima K, et al. Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am J Pathol. 2006 Jun. 168(6):2036-53. [QxMD MEDLINE Link]. [Full Text].

7. CDC. Prevalence of Age-Related Macular Degeneration (AMD). Centers for Disease Control and Prevention. Available at https://www.cdc.gov/visionhealth/vehss/estimates/amd-prevalence.html. October 31, 2022; Accessed: December 20, 2022.

8. Tielsch JM, Javitt JC, Coleman A, Katz J, Sommer A. The prevalence of blindness and visual impairment among nursing home residents in Baltimore. N Engl J Med. 1995 May 4. 332(18):1205-9. [QxMD MEDLINE Link].

9. Friedman DS, O'Colmain BJ, Munoz B, Tomany SC, McCarty C, de Jong PT, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004 Apr. 122(4):564-72. [QxMD MEDLINE Link].

10. Klein R, Davis MD, Magli YL, Segal P, Klein BE, Hubbard L. The Wisconsin age-related maculopathy grading system. Ophthalmology. 1991 Jul. 98(7):1128-34. [QxMD MEDLINE Link].

11. Davis MD, Gangnon RE, Lee LY, Hubbard LD, Klein BE, Klein R, et al. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol. 2005 Nov. 123(11):1484-98. [QxMD MEDLINE Link]. [Full Text].

12. Klein ML, Francis PJ, Ferris FL 3rd, Hamon SC, Clemons TE. Risk assessment model for development of advanced age-related macular degeneration. Arch Ophthalmol. 2011 Dec. 129(12):1543-50. [QxMD MEDLINE Link].

13. Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol. 1995 Mar-Apr. 39(5):367-74. [QxMD MEDLINE Link].

14. Davis MD, Gangnon RE, Lee LY, Hubbard LD, Klein BE, Klein R, et al. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol. 2005 Nov. 123(11):1484-98. [QxMD MEDLINE Link].

15. Klein R, Peto T, Bird A, Vannewkirk MR. The epidemiology of age-related macular degeneration. Am J Ophthalmol. 2004 Mar. 137(3):486-95. [QxMD MEDLINE Link].

16. Mares-Perlman JA, Brady WE, Klein R, VandenLangenberg GM, Klein BE, Palta M. Dietary fat and age-related maculopathy. Arch Ophthalmol. 1995 Jun. 113(6):743-8. [QxMD MEDLINE Link].

17. Chong EW, Kreis AJ, Wong TY, Simpson JA, Guymer RH. Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis. Arch Ophthalmol. 2008 Jun. 126(6):826-33. [QxMD MEDLINE Link].

18. Seddon JM, Rosner B, Sperduto RD, Yannuzzi L, Haller JA, Blair NP, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001 Aug. 119(8):1191-9. [QxMD MEDLINE Link].

19. Chong EW, Robman LD, Simpson JA, Hodge AM, Aung KZ, Dolphin TK, et al. Fat consumption and its association with age-related macular degeneration. Arch Ophthalmol. 2009 May. 127(5):674-80. [QxMD MEDLINE Link].

20. Chua B, Flood V, Rochtchina E, Wang JJ, Smith W, Mitchell P. Dietary fatty acids and the 5-year incidence of age-related maculopathy. Arch Ophthalmol. 2006 Jul. 124(7):981-6. [QxMD MEDLINE Link].

21. Seddon JM, Cote J, Davis N, Rosner B. Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio. Arch Ophthalmol. 2003 Jun. 121(6):785-92. [QxMD MEDLINE Link].

22. Okubo A, Rosa RH, Fan JT, et al. RPE residual body content, autofluorescence and aging. Invest Ophthalmol Vis Sci. 1996. 37(suppl):380.

23. von Ruckmann A, Fitzke FW, Bird AC. In vivo fundus autofluorescence in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1997. 38:478-86.

24. Edwards AO, Ritter R 3rd, Abel KJ, Manning A, Panhuysen C, Farrer LA. Complement factor H polymorphism and age-related macular degeneration. Science. 2005 Apr 15. 308(5720):421-4. [QxMD MEDLINE Link].

25. Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005 Apr 15. 308(5720):419-21. [QxMD MEDLINE Link].

26. Hageman GS, Anderson DH, Johnson LV. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA. 2005. 102:7227-32.

27. Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB. Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet. 2005 Sep. 77(3):389-407. [QxMD MEDLINE Link].

28. Gold B, Merriam JE, Zernant J. Variation in factor B (BF) and complement component 2 (C2)genes is associated with age-related macular degeneration. Nat Genet. 2006. 38:458-62.

29. Johnson LV, Leitner WP, Staples MK, Anderson DH. Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. Exp Eye Res. 2001 Dec. 73(6):887-96. [QxMD MEDLINE Link].

30. Esparza-Gordillo J, Soria JM, Buil A, Almasy L, Blangero J, Fontcuberta J. Genetic and environmental factors influencing the human factor H plasma levels. Immunogenetics. 2004 May. 56(2):77-82. [QxMD MEDLINE Link].

31. Sepp T, Khan JC, Thurlby DA, Shahid H, Clayton DG, Moore AT, et al. Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest Ophthalmol Vis Sci. 2006 Feb. 47(2):536-40. [QxMD MEDLINE Link].

32. Brody BL, Gamst AC, Williams RA, et al. Depression, visual acuity, comorbidity, and disability associated with age-related macular degeneration. Ophthalmology. 2001 Oct. 108(10):1893-900; discussion 1900-1. [QxMD MEDLINE Link].

33. Casten RJ, Rovner BW, Tasman W. Age-related macular degeneration and depression: a review of recent research. Curr Opin Ophthalmol. 2004 Jun. 15(3):181-3. [QxMD MEDLINE Link].

34. Coleman AL, Stone K, Ewing SK, Nevitt M, Cummings S, Cauley JA, et al. Higher risk of multiple falls among elderly women who lose visual acuity. Ophthalmology. 2004 May. 111(5):857-62. [QxMD MEDLINE Link].

35. Dong LM, Childs AL, Mangione CM, Bass EB, Bressler NM, Hawkins BS, et al. Health- and vision-related quality of life among patients with choroidal neovascularization secondary to age-related macular degeneration at enrollment in randomized trials of submacular surgery: SST report no. 4. Am J Ophthalmol. 2004 Jul. 138(1):91-108. [QxMD MEDLINE Link].

36. Vision and quality-of-life. Brown GC. Trans Am Ophthalmol Soc. 1999. 97:473-511.

37. Sommer A, Tielsch JM, Katz J, Quigley HA, Gottsch JD, Javitt JC, et al. Racial differences in the cause-specific prevalence of blindness in east Baltimore. N Engl J Med. 1991 Nov 14. 325(20):1412-7. [QxMD MEDLINE Link].

38. Cruickshanks KJ, Klein R, Klein BE. Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol. 1993 Apr. 111(4):514-8. [QxMD MEDLINE Link].

39. Das BN, Thompson JR, Patel R, Rosenthal AR. The prevalence of eye disease in Leicester: a comparison of adults of Asian and European descent. J R Soc Med. 1994 Apr. 87(4):219-22. [QxMD MEDLINE Link].

40. Miyazaki M, Nakamura H, Kubo M, Kiyohara Y, Oshima Y, Ishibashi T, et al. Risk factors for age related maculopathy in a Japanese population: the Hisayama study. Br J Ophthalmol. 2003 Apr. 87(4):469-72. [QxMD MEDLINE Link].

41. Klein R, Klein BE, Linton KL. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1992 Jun. 99(6):933-43. [QxMD MEDLINE Link].

42. Klein R, Rowland ML, Harris MI. Racial/ethnic differences in age-related maculopathy. Third National Health and Nutrition Examination Survey. Ophthalmology. 1995 Mar. 102(3):371-81. [QxMD MEDLINE Link].

43. Kini MM, Leibowitz HM, Colton T, Nickerson RJ, Ganley J, Dawber TR. Prevalence of senile cataract, diabetic retinopathy, senile macular degeneration, and open-angle glaucoma in the Framingham eye study. Am J Ophthalmol. 1978 Jan. 85(1):28-34. [QxMD MEDLINE Link].

44. Leibowitz HM, Krueger DE, Maunder LR, Milton RC, Kini MM, Kahn HA, et al. The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. Surv Ophthalmol. 1980 May-Jun. 24:335-610. [QxMD MEDLINE Link].

45. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997 Jan. 104(1):7-21. [QxMD MEDLINE Link].

46. Seddon JM, Cote J, Davis N, Rosner B. Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio. Arch Ophthalmol. 2003 Jun. 121(6):785-92. [QxMD MEDLINE Link].

47. Bressler NM, Bressler SB, Congdon NG, Ferris FL 3rd, Friedman DS, et al. Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11. Arch Ophthalmol. 2003 Nov. 121(11):1621-4. [QxMD MEDLINE Link].

48. Lee CS, Larson EB, Gibbons LE, Lee AY, McCurry SM, Bowen JD, et al. Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease. Alzheimers Dement. 2018 Aug 2. [QxMD MEDLINE Link].

49. Seddon JM, Ajani UA, Mitchell BD. Familial aggregation of age-related maculopathy. Am J Ophthalmol. 1997 Feb. 123(2):199-206. [QxMD MEDLINE Link].

50. Seddon JM, Willett WC, Speizer FE, Hankinson SE. A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA. 1996 Oct 9. 276(14):1141-6. [QxMD MEDLINE Link].

51. Christen WG, Glynn RJ, Manson JE, Ajani UA, Buring JE. A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA. 1996 Oct 9. 276(14):1147-51. [QxMD MEDLINE Link].

52. Christen WG, Schaumberg DA, Glynn RJ, Buring JE. Dietary {omega}-3 Fatty Acid and Fish Intake and Incident Age-Related Macular Degeneration in Women. Arch Ophthalmol. 2011 Jul. 129(7):921-9. [QxMD MEDLINE Link]. [Full Text].

53. Seddon JM, George S, Rosner B. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration. Arch Ophthalmol. 2006 Jul. 124(7):995-1001. [QxMD MEDLINE Link].

54. Yannuzzi LA. Indocyanine green angiography: a perspective on use in the clinical setting. Am J Ophthalmol. 2011 May. 151(5):745-751.e1. [QxMD MEDLINE Link].

55. Hee MR, Baumal CR, Puliafito CA, Duker JS, Reichel E, Wilkins JR, et al. Optical coherence tomography of age-related macular degeneration and choroidal neovascularization. Ophthalmology. 1996 Aug. 103(8):1260-70. [QxMD MEDLINE Link].

56. Ting TD, Oh M, Cox TA, Meyer CH, Toth CA. Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degeneration. Arch Ophthalmol. 2002 Jun. 120(6):731-7. [QxMD MEDLINE Link].

57. Sahni J, Stanga P, Wong D, Harding S. Optical coherence tomography in photodynamic therapy for subfoveal choroidal neovascularisation secondary to age related macular degeneration: a cross sectional study. Br J Ophthalmol. 2005 Mar. 89(3):316-20. [QxMD MEDLINE Link].

58. Piccolino FC, de la Longrais RR, Ravera G, Eandi CM, Ventre L, Abdollahi A, et al. The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy. Am J Ophthalmol. 2005 Jan. 139(1):87-99. [QxMD MEDLINE Link].

59. Rogers AH, Martidis A, Greenberg PB, Puliafito CA. Optical coherence tomography findings following photodynamic therapy of choroidal neovascularization. Am J Ophthalmol. 2002 Oct. 134(4):566-76. [QxMD MEDLINE Link].

60. Rosenfeld P, Rich RM, Lalwani GA. Ranibizumab: Phase II clinical trial results. Ophthalmology Clinics of North America. 2006. 19:361-72.

61. Spaide RF. Optical coherence tomography angiography signs of vascular abnormalization with antiangiogenic therapy for choroidal neovascularization. Am J Ophthalmol. 04/12/2015. 160:6-16. [QxMD MEDLINE Link]. [Full Text].

62. Tolentino MJ, Brucker AJ, Fosnot J, Ying GS, Wu IH, Malik G, et al. Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization. Retina. 2004 Feb. 24(1):132-8. [QxMD MEDLINE Link].

63. Tolentino MJ, Husain D, Theodosiadis P, Gragoudas ES, Connolly E, Kahn J, et al. Angiography of fluoresceinated anti-vascular endothelial growth factor antibody and dextrans in experimental choroidal neovascularization. Arch Ophthalmol. 2000 Jan. 118(1):78-84. [QxMD MEDLINE Link].

64. Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006 Oct 5. 355(14):1432-44. [QxMD MEDLINE Link].

65. Genetech Press Release. Preliminary Results from a Phase IIIb Study Showed Patients with Wet AMD Treated with Lucentis Quarterly Experienced a 16-Letter Benefit over the Control Group at One Year. Available at http://www.gene.com/gene/news/press-releases/display.do?method=detail&id=9747. Accessed: 2/21/2008.

66. Singer MA, Awh CC, Sadda S, Freeman WR, Antoszyk AN, Wong P, et al. HORIZON: An Open-Label Extension Trial of Ranibizumab for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. Ophthalmology. 2012 Feb 4. [QxMD MEDLINE Link].

67. Schmidt-Erfurth U, Eldem B, Guymer R, Korobelnik JF, Schlingemann RO, Axer-Siegel R, et al. Efficacy and Safety of Monthly versus Quarterly Ranibizumab Treatment in Neovascular Age-related Macular Degeneration: The EXCITE Study. Ophthalmology. 2011 May. 118(5):831-9. [QxMD MEDLINE Link].

68. Fung AE, Lalwani GA, Rosenfeld PJ, Dubovy SR, Michels S, Feuer WJ. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol. 2007 Apr. 143(4):566-83. [QxMD MEDLINE Link].

69. Holz FG, Korobelnik JF, Lanzetta P, Mitchell P, Schmidt-Erfurth U, Wolf S, et al. The effects of a flexible visual acuity-driven ranibizumab treatment regimen in age-related macular degeneration: outcomes of a drug and disease model. Invest Ophthalmol Vis Sci. 2010 Jan. 51(1):405-12. [QxMD MEDLINE Link].

70. Spaide R. Ranibizumab according to need: a treatment for age-related macular degeneration. Am J Ophthalmol. 2007 Apr. 143(4):679-80. [QxMD MEDLINE Link].

71. Brown DM, Regillo CD. Anti-VEGF agents in the treatment of neovascular age-related macular degeneration: applying clinical trial results to the treatment of everyday patients. Am J Ophthalmol. 2007 Oct. 144(4):627-37. [QxMD MEDLINE Link].

72. Gupta OP, Shienbaum G, Patel AH, et al. A treat and extend regimen using ranibizumab for neovascular age-related macular degeneration clinical and economic impact. Ophthalmology. 2010. 117:2134-2140.

73. Shienbaum G, Gupta OP, Fecarotta C, et al. Management of neovascular age- related macular degeneration using bevacizumab with the treat and extend regimen: clinical results and economic impact. In: ARVO; Fort Lauderdale, Florida; 2010.

74. Silva R, Axer-Siegel R, Eldem B, Guymer R, Kirchhof B, Papp A, et al. The SECURE Study: Long-Term Safety of Ranibizumab 0.5 mg in Neovascular Age-Related Macular Degeneration. Ophthalmology. 2012 Sep 25. [QxMD MEDLINE Link].

75. Dixon JA, Oliver SC, Olson JL, Mandava N. VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration. Expert Opin Investig Drugs. 2009 Oct. 18(10):1573-80. [QxMD MEDLINE Link].

76. Regeneron announces FDA approval of Eylea™ (aflibercept) injection for the treatment of wet age-related macular degeneration; 18 November 2011. Available at http://www.multivu.com/mnr/51268-eylea-aflibercept-wet-age-related-macular-degeneration-AMD-FDA-approval. Accessed: 22 November 2011.

77. Brown DM, Heier JS, Ciulla T, Benz M, Abraham P, Yancopoulos G, et al. Primary Endpoint Results of a Phase II Study of Vascular Endothelial Growth Factor Trap-Eye in Wet Age-related Macular Degeneration. Ophthalmology. 2011 Jun. 118(6):1089-97. [QxMD MEDLINE Link].

78. Heier JS, Boyer D, Nguyen QD, Marcus D, Roth DB, Yancopoulos G, et al. The 1-year Results of CLEAR-IT 2, a Phase 2 Study of Vascular Endothelial Growth Factor Trap-Eye Dosed As-needed After 12-week Fixed Dosing. Ophthalmology. 2011 Jun. 118(6):1098-106. [QxMD MEDLINE Link].

79. Spitzer MS. Intravitreal aflibercept 8 mg injection in patients with neovascular age-related macular degeneration: 48-week results from the Phase 3 PULSAR trial (abstract). Presented at the 2023 ARVO Annual Meeting. New Orleans, LA. Investigative Ophthalmology & Visual Science. June 2023. 64(461):[Full Text].

80. Eylea (aflibercept intravitreal) [package insert]. Tarrytown, NY: Regeneron Pharmaceutical, Inc. August, 2018. Available at [Full Text].

81. Dugel PU, Koh A, Ogura Y, Jaffe GJ, Schmidt-Erfurth U, Brown DM, et al. HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration. Ophthalmology. 2019 Apr 12. [QxMD MEDLINE Link]. [Full Text].

82. Heier JS, Khanani AM, Quezada Ruiz C, and the, TENAYA and LUCERNE Investigators. Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials. Lancet. 2022 Jan 21. [QxMD MEDLINE Link].

83. Genentech. Avastin [Genentech Web site]. Available at: http://www.gene.com/gene/products/information/oncology/avastin/index.jsp. Accessed June 28, 2005. [Full Text].

84. US Food and Drug Administration. FDA alerts health care professionals of infection risk from repackaged Avastin intravitreal injections. Available at http://www.fda.gov/Drugs/DrugSafety/ucm270296.htm. Accessed: August 31, 2011.

85. Michels S, Rosenfeld PJ, Puliafito CA, et al. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study. Ophthalmology. 2005 Jun. 112(6):1035-47. [QxMD MEDLINE Link].

86. Rosenfeld PJ, Moshfeghi AA, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging. 2005 Jul-Aug. 36(4):331-5. [QxMD MEDLINE Link].

87. Yoganathan P, Deramo VA, Lai JC, Tibrewala RK, Fastenberg DM. Visual improvement following intravitreal bevacizumab (Avastin) in exudative age-related macular degeneration. Retina. 2006 Nov-Dec. 26(9):994-8. [QxMD MEDLINE Link].

88. Emerson MV, Lauer AK, Flaxel CJ, Wilson DJ, Francis PJ, Stout JT. Intravitreal bevacizumab (Avastin) treatment of neovascular age-related macular degeneration. Retina. 2007 Apr-May. 27(4):439-44. [QxMD MEDLINE Link].

89. Abraham-Marin ML, Cortes-Luna CF, Alvarez-Rivera G, Hernandez-Rojas M, Quiroz-Mercado H, Morales-Canton V. Intravitreal bevacizumab therapy for neovascular age-related macular degeneration: a pilot study. Graefes Arch Clin Exp Ophthalmol. 2007 May. 245(5):651-5. [QxMD MEDLINE Link].

90. Bashshur ZF, Schakal A, Hamam RN, El Haibi CP, Jaafar RF, Noureddin BN. Intravitreal bevacizumab vs verteporfin photodynamic therapy for neovascular age-related macular degeneration. Arch Ophthalmol. 2007 Oct. 125(10):1357-61. [QxMD MEDLINE Link].

91. Lazic R, Gabric N. Verteporfin therapy and intravitreal bevacizumab combined and alone in choroidal neovascularization due to age-related macular degeneration. Ophthalmology. 2007 Jun. 114(6):1179-85. [QxMD MEDLINE Link].

92. Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, Jaffe GJ. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011 May 19. 364(20):1897-908. [QxMD MEDLINE Link].

93. Martin DF, Maguire MG, Fine SL, Ying GS, Jaffe GJ, Grunwald JE, et al. Ranibizumab and Bevacizumab for Treatment of Neovascular Age-Related Macular Degeneration: Two-Year Results. Ophthalmology. 2012 Apr 26. [QxMD MEDLINE Link].

94. Cavalcante LL, Cavalcante ML, Murray TG, et al. Intravitreal injection analysis at the Bascom Palmer Eye Institute: evaluation of clinical indications for the treatment and incidence rates of endophthalmitis. Clin Ophthalmol. 2010 May 25. 4:519-24. [QxMD MEDLINE Link]. [Full Text].

95. Mason JO 3rd, White MF, Feist RM, et al. Incidence of acute onset endophthalmitis following intravitreal bevacizumab (Avastin) injection. Retina. 2008 Apr. 28(4):564-7. [QxMD MEDLINE Link].

96. Fintak DR, Shah GK, Blinder KJ, et al. Incidence of endophthalmitis related to intravitreal injection of bevacizumab and ranibizumab. Retina. 2008 Nov-Dec. 28(10):1395-9. [QxMD MEDLINE Link].

97. Pilli S, Kotsolis A, Spaide RF, et al. Endophthalmitis associated with intravitreal anti-vascular endothelial growth factor therapy injections in an office setting. Am J Ophthalmol. 2008 May. 145(5):879-82. [QxMD MEDLINE Link].

98. Diago T, McCannel CA, Bakri SJ, et al. Infectious endophthalmitis after intravitreal injection of antiangiogenic agents. Retina. 2009 May. 29(5):601-5. [QxMD MEDLINE Link].

99. McCannel CA. Meta-analysis of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents: causative organisms and possible prevention strategies. Retina. 2011 Apr. 31(4):654-61. [QxMD MEDLINE Link].

100. Wen JC, McCannel CA, Mochon AB, Garner OB. Bacterial dispersal associated with speech in the setting of intravitreous injections. Arch Ophthalmol. 2011 Dec. 129(12):1551-4. [QxMD MEDLINE Link].

101. Markiewski MM, Daugherity E, Reese B, Karbowniczek M. The Role of Complement in Angiogenesis. Antibodies (Basel). 2020 Dec 1. 9 (4):[QxMD MEDLINE Link]. [Full Text].

102. Marcus A. FDA Oks First Drug for Geographic Atrophy, a Major cause of Adult Blindness. Medscape Medical News. 2023 Feb 17. Available at https://www.medscape.com/viewarticle/988460.

103. Patel SS, Lally DR, Hsu J, Wykoff CC, Eichenbaum D, Heier JS, et al. Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial. Eye (Lond). 2023 Mar 24. [QxMD MEDLINE Link]. [Full Text].

104. Gehlbach P, Li T, Hatef E. Statins for age-related macular degeneration. Cochrane Database Syst Rev. 2009 Jul 8. CD006927. [QxMD MEDLINE Link].

105. Chuo JY, Wiens M, Etminan M, Maberley DA. Use of lipid-lowering agents for the prevention of age-related macular degeneration: a meta-analysis of observational studies. Ophthalmic Epidemiol. 2007 Nov-Dec. 14(6):367-74. [QxMD MEDLINE Link].

106. MPS Group. Macular Photocoagulation Study Group. Argon laser photocoagulation for senile macular degeneration. Results of a randomized clinical trial. Arch Ophthalmol. 1982 Jun. 100(6):912-8. [QxMD MEDLINE Link].

107. MPS Group. Macular Photocoagulation Study Group. Argon laser photocoagulation for neovascular maculopathy. Three-year results from randomized clinical trials. Arch Ophthalmol. 1986 May. 104(5):694-701. [QxMD MEDLINE Link].

108. MPS Group. Argon laser photocoagulation for neovascular maculopathy. Five-year results from randomized clinical trials. Macular Photocoagulation Study Group. Arch Ophthalmol. 1991 Aug. 109(8):1109-14. [QxMD MEDLINE Link].

109. MPS Group. Macular Photocoagulation Study Group. Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization. Arch Ophthalmol. 1993 Sep. 111(9):1189-99. [QxMD MEDLINE Link].

110. Freund KB, Yannuzzi LA, Sorenson JA. Age-related macular degeneration and choroidal neovascularization. Am J Ophthalmol. 1993 Jun 15. 115(6):786-91. [QxMD MEDLINE Link].

111. Moisseiev J, Alhalel A, Masuri R, Treister G. The impact of the macular photocoagulation study results on the treatment of exudative age-related macular degeneration. Arch Ophthalmol. 1995 Feb. 113(2):185-9. [QxMD MEDLINE Link].

112. Nishijima K, Takahashi M, Akita J, Katsuta H, Tanemura M, Aikawa H, et al. Laser photocoagulation of indocyanine green angiographically identified feeder vessels to idiopathic polypoidal choroidal vasculopathy. Am J Ophthalmol. 2004 Apr. 137(4):770-3. [QxMD MEDLINE Link].

113. Shiraga F, Ojima Y, Matsuo T, Takasu I, Matsuo N. Feeder vessel photocoagulation of subfoveal choroidal neovascularization secondary to age-related macular degeneration. Ophthalmology. 1998 Apr. 105(4):662-9. [QxMD MEDLINE Link].

114. Reichel E, Musch DC, Blodi BA. Results from the TTT4CNV clinical trial. Invest Ophthalmol Vis Sci. 2005. 46:E-abstract 2311.

115. Aveline B, Hasan T, Redmond RW. Photophysical and photosensitizing properties of benzoporphyrin derivative monoacid ring A (BPD-MA). Photochem Photobiol. 1994 Mar. 59(3):328-35. [QxMD MEDLINE Link].

116. Allison BA, Waterfield E, Richter AM, Levy JG. The effects of plasma lipoproteins on in vitro tumor cell killing and in vivo tumor photosensitization with benzoporphyrin derivative. Photochem Photobiol. 1991 Nov. 54(5):709-15. [QxMD MEDLINE Link].

117. Hunt DW, Jiang H, Granville DJ, Chan AH, Leong S, Levy JG. Consequences of the photodynamic treatment of resting and activated peripheral T lymphocytes. Immunopharmacology. 1999 Jan. 41(1):31-44. [QxMD MEDLINE Link].

118. Novartis Ophthalmics. Visudyne launched in Japan for treatment of age-related macular degeneration [Novartis Web site]. May 10, 2004. Available at: http://www.us.novartisophthalmics.com/hcp/press-release/Visodyne_E_10.05.pdf. Accessed October 15, 2004. [Full Text].

119. Blumenkranz MS, Bressler NM, Bressler SB, Donati G, Fish GE, Haynes LA, et al. Verteporfin therapy for subfoveal choroidal neovascularization in age-related macular degeneration: three-year results of an open-label extension of 2 randomized clinical trials--TAP Report no. 5. Arch Ophthalmol. 2002 Oct. 120(10):1307-14. [QxMD MEDLINE Link].

120. Dhalla MS, Shah GK, Blinder KJ, Ryan EH Jr, Mittra RA, Tewari A. Combined photodynamic therapy with verteporfin and intravitreal bevacizumab for choroidal neovascularization in age-related macular degeneration. Retina. 2006 Nov-Dec. 26(9):988-93. [QxMD MEDLINE Link].

121. Augustin AJ, Puls S, Offermann I. Triple therapy for choroidal neovascularization due to age-related macular degeneration: verteporfin PDT, bevacizumab, and dexamethasone. Retina. 2007 Feb. 27(2):133-40. [QxMD MEDLINE Link].

122. Schmidt-Erfurth U, Schlötzer-Schrehard U, Cursiefen C, Michels S, Beckendorf A, Naumann GO. Influence of photodynamic therapy on expression of vascular endothelial growth factor (VEGF), VEGF receptor 3, and pigment epithelium-derived factor. Invest Ophthalmol Vis Sci. 2003 Oct. 44(10):4473-80. [QxMD MEDLINE Link].

123. Costagliola C, Romano MR, Rinaldi M, dell'Omo R, Chiosi F, Menzione M, et al. Low fluence rate photodynamic therapy combined with intravitreal bevacizumab for neovascular age-related macular degeneration. Br J Ophthalmol. 2010 Feb. 94(2):180-4. [QxMD MEDLINE Link].

124. Potter MJ, Claudio CC, Szabo SM. A randomised trial of bevacizumab and reduced light dose photodynamic therapy in age-related macular degeneration: the VIA study. Br J Ophthalmol. 2010 Feb. 94(2):174-9. [QxMD MEDLINE Link].

125. Lim JY, Lee SY, Kim JG, Lee JY, Chung H, Yoon YH. Intravitreal bevacizumab alone versus in combination with photodynamic therapy for the treatment of neovascular maculopathy in patients aged 50 years or older: 1-year results of a prospective clinical study. Acta Ophthalmol. 2010 Mar 16. [QxMD MEDLINE Link].

126. Kaiser PK, Boyer DS, Cruess AF, Slakter JS, Pilz S, Weisberger A. Verteporfin plus ranibizumab for choroidal neovascularization in age-related macular degeneration: twelve-month results of the DENALI study. Ophthalmology. 2012 May. 119(5):1001-10. [QxMD MEDLINE Link].

127. Larsen M, Schmidt-Erfurth U, Lanzetta P, Wolf S, Simader C, Tokaji E, et al. Verteporfin plus ranibizumab for choroidal neovascularization in age-related macular degeneration: twelve-month MONT BLANC study results. Ophthalmology. 2012 May. 119(5):992-1000. [QxMD MEDLINE Link].

128. Jackson TL, Chakravarthy U, Kaiser PK, Slakter JS, Jan E, Bandello F, et al. Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration: 52-Week Safety and Efficacy Results of the INTREPID Study. Ophthalmology. 2013 Mar 12. [QxMD MEDLINE Link].

129. Bressler NM, Bressler SB, Childs AL, Haller JA, Hawkins BS, Lewis H, et al. Surgery for hemorrhagic choroidal neovascular lesions of age-related macular degeneration: ophthalmic findings: SST report no. 13. Ophthalmology. 2004 Nov. 111(11):1993-2006. [QxMD MEDLINE Link].

130. Hawkins BS, Bressler NM, Miskala PH, Bressler SB, Holekamp NM, Marsh MJ, et al. Surgery for subfoveal choroidal neovascularization in age-related macular degeneration: ophthalmic findings: SST report no. 11. Ophthalmology. 2004 Nov. 111(11):1967-80. [QxMD MEDLINE Link].

131. Gragoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med. 2004 Dec 30. 351(27):2805-16. [QxMD MEDLINE Link].

132. Eyetech Pharmaceuticals. Eyetech announces launch date for Macugen (pegaptanib sodium injection) [Eyetech Web site]. January 20, 2005. Available at: http://media.corporate-ir.net/media_files/irol/13/134799/newspdfs/1-20-05.pdf. Accessed June 27, 2005. [Full Text].

133. Eyetech Pharmaceuticals. Pfizer and Eyetech provide regulatory update on Macugen (pegaptanib sodium injection) [Eyetech Web site]. September 20, 2004. Available at: http://media.corporate-ir.net/media_files/irol/13/134799/newspdfs/9-20-04-Update.pdf. Accessed October 12, 2004. [Full Text].

134. Kahn HA, Leibowitz HM, Ganley JP, Kini MM, Colton T, Nickerson RS, et al. The Framingham Eye Study. I. Outline and major prevalence findings. Am J Epidemiol. 1977 Jul. 106(1):17-32. [QxMD MEDLINE Link].

135. Attebo K, Mitchell P, Smith W. Visual acuity and the causes of visual loss in Australia. The Blue Mountains Eye Study. Ophthalmology. 1996 Mar. 103(3):357-64. [QxMD MEDLINE Link].

136. Klaver CC, Wolfs RC, Vingerling JR, Hofman A, de Jong PT. Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study. Arch Ophthalmol. 1998 May. 116(5):653-8. [QxMD MEDLINE Link].

F Ryan Prall, MD Assistant Professor of Ophthalmology, Indiana University School of Medicine

F Ryan Prall, MD is a member of the following medical societies: American Academy of Ophthalmology, American Society of Retina Specialists, Pan-American Association of Ophthalmology

Disclosure: Nothing to disclose.

Thomas A Ciulla, MD, MBA Clinical Professor (Volunteer) of Ophthalmology, Indiana University School of Medicine; Ophthalmologist, Vitreoretinal Medicine and Surgery, Midwest Eye Institute

Thomas A Ciulla, MD, MBA is a member of the following medical societies: Alpha Omega Alpha, American Academy of Ophthalmology, American Society of Gene and Cell Therapy, American Society of Retina Specialists, Association for Research in Vision and Ophthalmology, Indiana Academy of Ophthalmology, International Society for Genetic Eye Diseases and Retinoblastoma, Macula Society, Retina Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Ophthotech Corp.; Spark Therapeutics; Clearside Biomedical<br/>Received income in an amount equal to or greater than $250 from: Ophthotech Corp.; Spark Therapeutics; Clearside Biomedical.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Steve Charles, MD Founder and CEO of Charles Retina Institute; Clinical Professor, Department of Ophthalmology, University of Tennessee College of Medicine

Disclosure: Received royalty and consulting fees for: Alcon Laboratories.

Andrew A Dahl, MD, FACS Assistant Professor of Surgery (Ophthalmology), New York College of Medicine (NYCOM); Director of Residency Ophthalmology Training, The Institute for Family Health and Mid-Hudson Family Practice Residency Program; Staff Ophthalmologist, Telluride Medical Center

Andrew A Dahl, MD, FACS is a member of the following medical societies: American Academy of Ophthalmology, American College of Surgeons, American Intraocular Lens Society, American Medical Association, American Society of Cataract and Refractive Surgery, Contact Lens Association of Ophthalmologists, Medical Society of the State of New York, New York State Ophthalmological Society, Outpatient Ophthalmic Surgery Society

Disclosure: Nothing to disclose.

Brian A Phillpotts, MD Ophthalmologist, St Luke's Cataract and Laser Institute

Brian A Phillpotts, MD is a member of the following medical societies: American Academy of Ophthalmology, American Diabetes Association, American Society of Retina Specialists, Association for Research in Vision and Ophthalmology, Association of University Professors of Ophthalmology

Disclosure: Nothing to disclose.

Mark H Criswell, PhD Adjunct Assistant Research Professor, Department of Ophthalmology, Indiana University School of Medicine

Mark H Criswell, PhD is a member of the following medical societies: Association for Research in Vision and Ophthalmology

Disclosure: Nothing to disclose.

Alon Harris, PhD Lois Letzter Professor, Director of Glaucoma Research and Diagnostic Center, Department of Ophthalmology, Indiana University School of Medicine

Alon Harris, PhD is a member of the following medical societies: American College of Sports Medicine, American Physiological Society, American Society for Laser Medicine and Surgery, New York Academy of Sciences

Disclosure: Nothing to disclose.

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous author, Grant M Comer, MD, to the development and writing of this article.

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