Chloroquine and Hydroxychloroquine Toxicity Guidelines

Updated: Jul 30, 2020
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Andrew G Lee, MD  more...
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Guidelines Summary

The American Academy of Ophthalmology released revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy in 2016. [22]

All patients must undergo a baseline dilated fundus examination to rule out preexisting maculopathy. Patients on acceptable doses and without major risk factors may undergo annual screening 5 years after initiation of treatment.

The primary screening tests include automated visual field and SD-OCT. Useful additional objective tests include functional multifocal electroretinography (mfERG) and structural fundus autofluorescence (FAF).