Charcot Arthropathy Questions & Answers

1. Kelly M. William Musgrave’s De Arthritide Symptomatica (1703): His description of neuropathic arthritis. Bull Hist Med. 1963. 37:372-6.

2. Charcot JM. Sur quelaques arthropathies qui paraissent depender d’une lesion du cerveau ou de la moele epiniere. Arch Des Physiol Norm et Path. 1868. 1:161-71.

3. Saunders LJ, Mrdjencovich D. Anatomical patterns of bone and joint destruction in neuropathic diabetics. Diabetes. 1991. 40:529A.

4. Schon LC, Easley ME, Weinfeld SB. Charcot neuroarthropathy of the foot and ankle. Clin Orthop Relat Res. 1998 Apr. (349):116-31. [QxMD MEDLINE Link].

5. Jansen RB, Svendsen OL. A review of bone metabolism and developments in medical treatment of the diabetic Charcot foot. J Diabetes Complications. 2018 Jul. 32 (7):708-712. [QxMD MEDLINE Link].

6. van der Ven A, Chapman CB, Bowker JH. Charcot neuroarthropathy of the foot and ankle. J Am Acad Orthop Surg. 2009 Sep. 17 (9):562-71. [QxMD MEDLINE Link].

7. Edmonds M, Manu C, Vas P. The current burden of diabetic foot disease. J Clin Orthop Trauma. 2021 Jun. 17:88-93. [QxMD MEDLINE Link]. [Full Text].

8. Grear BJ, Rabinovich A, Brodsky JW. Charcot arthropathy of the foot and ankle associated with rheumatoid arthritis. Foot Ankle Int. 2013 Nov. 34 (11):1541-7. [QxMD MEDLINE Link].

9. Stark C, Murray T, Gooday C, Nunney I, Hutchinson R, Loveday D, et al. 5 year retrospective follow-up of new cases of Charcot neuroarthropathy-A single centre experience. Foot Ankle Surg. 2016 Sep. 22 (3):176-80. [QxMD MEDLINE Link].

10. Lee M, Choi WJ, Han SH, Jang J, Lee JW. Uncontrolled diabetes as a potential risk factor in tibiotalocalcaneal fusion using a retrograde intramedullary nail. Foot Ankle Surg. 2018 Dec. 24 (6):542-548. [QxMD MEDLINE Link].

11. Shazadeh Safavi K, Janney C, Shazadeh Safavi P, Kunzler D, Jupiter D, Panchbhavi V. Inappropriate antibiotic administration in the setting of Charcot arthropathy: A case series and literature review. Prim Care Diabetes. 2022 Feb. 16 (1):202-206. [QxMD MEDLINE Link].

12. Panchbhavi VK, Villarreal AD. Treatment of acute Lisfranc fracture and dislocation in patients with neuropathy. Tech Foot Ankle Surg. 2010. 9 (3):115-22.

13. López-Moral M, Molines-Barroso RJ, Sanz-Corbalán I, Tardáguila-García A, García-Madrid M, Lázaro-Martínez JL. Predictive Radiographic Values for Foot Ulceration in Persons with Charcot Foot Divided by Lateral or Medial Midfoot Deformity. J Clin Med. 2022 Jan 18. 11 (3):[QxMD MEDLINE Link]. [Full Text].

14. Schlossbauer T, Mioc T, Sommerey S, Kessler SB, Reiser MF, Pfeifer KJ. Magnetic resonance imaging in early stage charcot arthropathy: correlation of imaging findings and clinical symptoms. Eur J Med Res. 2008 Sep 22. 13 (9):409-14. [QxMD MEDLINE Link].

15. Ulbrecht JS, Wukich DK. The Charcot foot: medical and surgical therapy. Curr Diab Rep. 2008 Dec. 8 (6):444-51. [QxMD MEDLINE Link].

16. Grant WP, Garcia-Lavin SE, Sabo RT, Tam HS, Jerlin E. A retrospective analysis of 50 consecutive Charcot diabetic salvage reconstructions. J Foot Ankle Surg. 2009 Jan-Feb. 48(1):30-8. [QxMD MEDLINE Link].

17. Simon SR, Tejwani SG, Wilson DL, Santner TJ, Denniston NL. Arthrodesis as an early alternative to nonoperative management of charcot arthropathy of the diabetic foot. J Bone Joint Surg Am. 2000 Jul. 82-A (7):939-50. [QxMD MEDLINE Link].

18. Schneekloth BJ, Lowery NJ, Wukich DK. Charcot Neuroarthropathy in Patients With Diabetes: An Updated Systematic Review of Surgical Management. J Foot Ankle Surg. 2016 May-Jun. 55 (3):586-90. [QxMD MEDLINE Link].

19. Wang Y, Zhou J, Yan F, Li G, Duan X, Pan H, et al. Comparison of Arthrodesis with Total Contact Casting for Midfoot Ulcerations Associated with Charcot Neuroarthropathy. Med Sci Monit. 2015 Jul 24. 21:2141-8. [QxMD MEDLINE Link]. [Full Text].

20. Verity S, Sochocki M, Embil JM, Trepman E. Treatment of Charcot foot and ankle with a prefabricated removable walker brace and custom insole. Foot Ankle Surg. 2008. 14 (1):26-31. [QxMD MEDLINE Link].

21. Guis S, Pellissier JF, Arniaud D, Turck F, Witjas T, Roux H, et al. Healing of Charcot's joint by pamidronate infusion. J Rheumatol. 1999 Aug. 26 (8):1843-5. [QxMD MEDLINE Link].

22. Selby PL, Young MJ, Boulton AJ. Bisphosphonates: a new treatment for diabetic Charcot neuroarthropathy?. Diabet Med. 1994 Jan-Feb. 11 (1):28-31. [QxMD MEDLINE Link].

23. Strauss E, Gonya G. Adjunct low intensity ultrasound in Charcot neuroarthropathy. Clin Orthop Relat Res. 1998 Apr. (349):132-8. [QxMD MEDLINE Link].

24. Yammine K, Otayek J, Assi C. Evidence-based conservative limb preserving surgery for the diabetic foot complications: A systematic review of systematic reviews. Foot Ankle Surg. 2021 Aug 27. [QxMD MEDLINE Link].

25. Frøkjær J. Surgical treatment of midfoot charcot neuroarthropathy review of literature and our results after superconstruct reconstruction of midfoot charcot neuroarthropathy. J Clin Orthop Trauma. 2021 Jun. 17:59-64. [QxMD MEDLINE Link]. [Full Text].

26. Wirth SH, Espinosa N, Berli M, Jankauskas L. [Complex reconstruction in Charcot arthropathy using the Ilizarov ring fixator]. Orthopade. 2015 Jan. 44 (1):50-7. [QxMD MEDLINE Link].

27. Sohn MW, Stuck RM, Pinzur M, Lee TA, Budiman-Mak E. Lower-extremity amputation risk after charcot arthropathy and diabetic foot ulcer. Diabetes Care. 2010 Jan. 33 (1):98-100. [QxMD MEDLINE Link]. [Full Text].

28. Dalla Paola L, Brocco E, Ceccacci T, Ninkovic S, Sorgentone S, Marinescu MG, et al. Limb salvage in Charcot foot and ankle osteomyelitis: combined use single stage/double stage of arthrodesis and external fixation. Foot Ankle Int. 2009 Nov. 30 (11):1065-70. [QxMD MEDLINE Link].

29. Hegewald KW, Wilder ML, Chappell TM, Hutchinson BL. Combined Internal and External Fixation for Diabetic Charcot Reconstruction: A Retrospective Case Series. J Foot Ankle Surg. 2016 May-Jun. 55 (3):619-27. [QxMD MEDLINE Link].

30. Bajuri MY, Ong SL, Das S, Mohamed IN. Charcot Neuroarthropathy: Current Surgical Management and Update. A Systematic Review. Front Surg. 2022. 9:820826. [QxMD MEDLINE Link]. [Full Text].

31. Galhoum AE, Abd-Ella MM, Zahlawy HE, Tejero S, Valderrabano V, Trivedi V, et al. Infected unstable Charcot ankle neuroarthropathy, any hope before amputation? A prospective study. Int Orthop. 2022 Apr 21. [QxMD MEDLINE Link].

32. Tiruveedhula M, Graham A, Thapar A, Dindyal S, Mulcahy M. Outcomes of Tendo-Achilles lengthening and weight-bearing total contact cast for management of early midfoot charcot neuroarthropathy. J Clin Orthop Trauma. 2021 Jun. 17:128-138. [QxMD MEDLINE Link]. [Full Text].

33. Ha J, Hester T, Foley R, Reichert ILH, Vas PRJ, Ahluwalia R, et al. Charcot foot reconstruction outcomes: A systematic review. J Clin Orthop Trauma. 2020 May-Jun. 11 (3):357-368. [QxMD MEDLINE Link]. [Full Text].

34. Lamm BM, Gottlieb HD, Paley D. A two-stage percutaneous approach to charcot diabetic foot reconstruction. J Foot Ankle Surg. 2010 Nov-Dec. 49 (6):517-22. [QxMD MEDLINE Link].

35. Miller RJ. Neuropathic Minimally Invasive Surgeries (NEMESIS):: Percutaneous Diabetic Foot Surgery and Reconstruction. Foot Ankle Clin. 2016 Sep. 21 (3):595-627. [QxMD MEDLINE Link].

36. Fraser TW, Miles DT, Huang N, Davis FB, Dunlap BD, Doty JF. Radiographic Outcomes, Union Rates, and Complications Associated With Plantar Implant Positioning for Midfoot Arthrodesis. Foot Ankle Orthop. 2021 Jul. 6 (3):24730114211027115. [QxMD MEDLINE Link]. [Full Text].

37. Siddiqui NA, Millonig KJ, Mayer BE, Fink JN, McClure PK, Bibbo C. Increased Arthrodesis Rates in Charcot Neuroarthropathy Utilizing Distal Tibial Distraction Osteogenesis Principles. Foot Ankle Spec. 2022 May 3. 19386400221087822. [QxMD MEDLINE Link].

38. Rana B, Patel S. Results of Ankle and Hind foot arthrodesis in Diabetic Charcot Neuroarthropathy - A retrospective analysis of 44 patients. J Clin Orthop Trauma. 2021 Dec. 23:101637. [QxMD MEDLINE Link].

39. [Guideline] Diabetic foot problems: prevention and management. National Institute for Health Care and Excellence. Available at https://www.nice.org.uk/guidance/ng19/chapter/Recommendations#treatment-2. October 11, 2019; Accessed: May 27, 2022.

Mrugeshkumar Shah, MD, MPH, MS Staff Physician, Physical Medicine and Rehabilitation, Massachusetts General Hospital/Spaulding Rehabilitation Hospital

Mrugeshkumar Shah, MD, MPH, MS is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation

Disclosure: Nothing to disclose.

Walter Panis, MD Clinical Instructor, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School

Walter Panis, MD is a member of the following medical societies: American Academy of Neurology, American Society of Neurorehabilitation, Massachusetts Medical Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Vinod K Panchbhavi, MD, FACS, FAOA, FABOS, FAAOS Professor of Orthopedic Surgery, Chief, Division of Foot and Ankle Surgery, Director, Foot and Ankle Fellowship Program, Department of Orthopedic Surgery, University of Texas Medical Branch School of Medicine

Vinod K Panchbhavi, MD, FACS, FAOA, FABOS, FAAOS is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Surgeons, American Orthopaedic Association, American Orthopaedic Foot and Ankle Society, Orthopaedic Trauma Association, Texas Orthopaedic Association

Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Styker.

James K DeOrio, MD Professor of Orthopedics, Director, Duke Foot and Ankle Fellowship, Duke University Medical Center, Duke University School of Medicine; Associate Professor, Mayo Clinic College of Medicine; Clinical Assistant Professor, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences

James K DeOrio, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Orthopaedic Foot and Ankle Society, Association of Graduates, United States Air Force Academy, Doctors Mayo Society, Mayo Clinic Alumni Association, Society of Air Force Clinical Surgeons, Society of Military Orthopaedic Surgeons

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Exactech; Treace Medical; Additive; Mirus; Crossroads Orthopedics<br/>Serve(d) as a speaker or a member of a speakers bureau for: Exactech; Treace Medical; Additive; Mirus; WoultersKluwer; Crossroads Orthopedics<br/>Received income in an amount equal to or greater than $250 from: Exactech; Treace Medical; Additive; Mirus; WoultersKluwer; Crossroads Orthopedics.

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