Type III Polyglandular Autoimmune Syndrome Differential Diagnoses

1. Kahaly GJ. Polyglandular autoimmune syndromes. Eur J Endocrinol. 2009 Jul. 161(1):11-20. [Medline]. [Full Text].

2. Neufeld M, Blizzard RM. Polyglandular autoimmune disease. Pinchera A, Doniach D, Fenzi DF, Baschieri L, eds. Autoimmune aspects of endocrine disorders. London, UK: Academic Press; 1980. 357-65.

3. Bahceci M, Tuzcu A, Pasa S, Ayyildiz O, Tuzcu S. Polyglandular autoimmune syndrome type III accompanied by common variable immunodeficiency. Gynecol Endocrinol. 2004 Jul. 19(1):47-50. [Medline].

4. Ugur-Altun B, Arikan E, Guldiken S, Kara M, Tugrul A. Autoimmune polyglandular syndrome type III in monozygotic twins: a case report. Acta Clin Belg. 2004 Jul-Aug. 59(4):225-8. [Medline].

5. Shimomura H, Nakase Y, Furuta H, Nishi M, Nakao T, Hanabusa T, et al. A rare case of autoimmune polyglandular syndrome type 3. Diabetes Res Clin Pract. 2003 Aug. 61(2):103-8. [Medline].

6. Oki K, Yamane K, Koide J, Mandai K, Nakanishi S, Fujikawa R, et al. A case of polyglandular autoimmune syndrome type III complicated with autoimmune hepatitis. Endocr J. 2006 Oct. 53(5):705-9. [Medline].

7. Noriko O, Junko T, Yuko Y, Toshiaki K, Masteru N, Tooru Y, et al. Autoimmune Polyglandular Syndrome Type III Associated with Slowly Progressive Type 1 Diabetes Mellitus, Chronic Thyroiditis, Pernicious Anemia and Idiopathic Thrombocytopenic Purpura: A Case Report. Journal of the Japan Diabetic Society. 2006. 49:723-729. [Full Text].

8. Lubinska M, Swiatkowska-Stodulska R, Kazimierska E, Sworczak K. Acquired von Willebrand's syndrome in a patient with severe primary hypothyroidism associated with myasthenia gravis in the course of autoimmune polyglandular syndrome type 3. Haemophilia. 2007 Sep. 13(5):675-6. [Medline]. [Full Text].

9. Turkoglu Z, Kavala M, Kolcak O, Zindanci I, Can B. Autoimmune polyglandular syndrome-3C in a child. Dermatol Online J. 2010 Mar 15. 16(3):8. [Medline].

10. Quintos JB, Grover M, Boney CM, Salas M. Autoimmune polyglandular syndrome Type 3 and growth hormone deficiency. Pediatr Diabetes. 2010 Sep. 11(6):438-42. [Medline].

11. Farkas K, Nagy F, Kovács L, Csajbók E, Kovács G, Wittmann T, et al. Ulcerative colitis and primary sclerosing cholangitis as part of autoimmune polyglandular syndrome type III. Inflamm Bowel Dis. 2010 Jan. 16(1):10-1. [Medline].

12. Krol TC. Myasthenia gravis, pernicious anemia, and Hashimoto's thyroiditis. Arch Neurol. 1979 Sep. 36(9):594-5. [Medline].

13. Briscoe NK, Mezei MM. Polyglandular autoimmune syndrome type 3 in a patient with ocular myasthenia gravis. Muscle Nerve. 2009 Dec. 40(6):1064-5. [Medline].

14. Betterle C, Garelli S, Coco G, Burra P. A rare combination of type 3 autoimmune polyendocrine syndrome (APS-3) or multiple autoimmune syndrome (MAS-3). Autoimmunity Highlights. 2014. 1-5.

15. Sternthal E, Like AA, Sarantis K, Braverman LE. Lymphocytic thyroiditis and diabetes in the BB/W rat. A new model of autoimmune endocrinopathy. Diabetes. 1981 Dec. 30(12):1058-61. [Medline].

16. Villano MJ, Huber AK, Greenberg DA, et al. Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. J Clin Endocrinol Metab. 2009 Apr. 94(4):1458-66. [Medline]. [Full Text].

17. Huber A, Menconi F, Corathers S, et al. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev. 2008 Oct. 29(6):697-725. [Medline]. [Full Text].

18. Fourati H, Mahfoudh N, Abida O, Kammoun A, Mnif F, Haddouk S, et al. HLA-DRB1/DQB1 susceptibility for autoimmune polyglandular syndrome type II and III in south of Tunisia. Ann Endocrinol (Paris). 2011 Jun. 72(3):232-8. [Medline].

19. Hansen MP, Matheis N, Kahaly GJ. Type 1 diabetes and polyglandular autoimmune syndrome: A review. World J Diabetes. 2015 Feb 15. 6 (1):67-79. [Medline].

20. Dittmar M, Kahaly GJ. Genetics of the autoimmune polyglandular syndrome type 3 variant. Thyroid. 2010 Jul. 20(7):737-43. [Medline].

21. Kim SJ, Kim SY, Kim HB, Chang H, Cho HC. Polyglandular Autoimmune Syndrome Type III with Primary Hypoparathyroidism. Endocrinol Metab (Seoul). 2013 Sep. 28(3):236-40. [Medline]. [Full Text].

22. Hunger-Battefeld W, Fath K, Mandecka A, et al. [Prevalence of polyglandular autoimmune syndrome in patients with diabetes mellitus type 1]. Med Klin (Munich). 2009 Mar 15. 104(3):183-91. [Medline].

23. Baker JR Jr. Autoimmune endocrine disease. JAMA. 1997 Dec 10. 278(22):1931-7. [Medline].

24. Chen Q, Kukreja A, Maclaren NK. The Autoimmune polyglandular syndromes. DeGroot LJ, Jameson JL. Endocrinology. 4th ed. Philadelphia, Pa: WB Saunders; 2001. Vol 1: 587-99.

25. Davidson A, Diamond B. Autoimmune diseases. N Engl J Med. 2001 Aug 2. 345(5):340-50. [Medline].

26. Dayan CM, Daniels GH. Chronic autoimmune thyroiditis. N Engl J Med. 1996 Jul 11. 335(2):99-107. [Medline].

27. Eisenbarth GS, Wilson PW, Ward F, Buckley C, Lebovita H. The polyglandular failure syndrome: disease inheritance, HLA type, and immune function. Ann Intern Med. 1979 Oct. 91(4):528-33. [Medline].

28. Kukreja A, Maclaren NK. Autoimmunity and diabetes. J Clin Endocrinol Metab. 1999 Dec. 84(12):4371-8. [Medline].

29. Leibowitz G, Amir G, Losses IS, Eliakim R. Autoimmune polyglandular failure associated with malabsorption and gastric carcinoid tumour. J Intern Med. 1993 Dec. 234(6):625-9. [Medline].

30. Leshin M. Polyglandular autoimmune syndromes. Am J Med Sci. 1985 Aug. 290(2):77-88. [Medline].

31. Obermayer-Straub P, Manns MP. Autoimmune polyglandular syndromes. Baillieres Clin Gastroenterol. 1998 Jun. 12(2):293-315. [Medline].

32. Price VH. Treatment of hair loss. N Engl J Med. 1999 Sep 23. 341(13):964-73. [Medline].

33. Rodriguez Quiroz F, Berron Perez R, Ortega Martell JA, Onuma Takane E. [Type III polyglandular autoimmune syndrome. Report of a case]. Allergol Immunopathol (Madr). 1995 Sep-Oct. 23(5):251-3. [Medline].

34. Sale MM, Akamizu T, Howard TD. Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population. Proc Assoc Am Physicians. 1997 Sep. 109(5):453-61. [Medline].

35. Sasso FC, Carbonara O, Di Micco P, Coppola L, Torella R, Niglio A. A case of autoimmune polyglandular syndrome developed after interferon-alpha therapy. Br J Clin Pharmacol. 2003 Aug. 56(2):238-9. [Medline].

36. Shaffrali F, Gawkrodger D. Management of vitiligo. Clin Exp Dermatol. 2000 Nov. 25(8):575-9. [Medline].

37. Shapiro J. Alopecia Areata: Clinical Features and Treatment Options in the 90's. Presented at the International NAAF Conference, Seattle, Washington. Saturday, July 6, 1996. [Full Text].

38. Trence DL, Morley JE, Handwerger BS. Polyglandular autoimmune syndromes. Am J Med. 1984 Jul. 77(1):107-16. [Medline].

39. Yanagawa T, Hidaka Y, Guimaraes V, Soliman M, DeGroot LJ. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population. J Clin Endocrinol Metab. 1995 Jan. 80(1):41-5. [Medline].

KoKo Aung, MD, MPH, FACP Professor of Internal Medicine, Associate Academic Dean, Assistant Vice President, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

KoKo Aung, MD, MPH, FACP is a member of the following medical societies: American College of Physicians, Association of American Medical Colleges, Society of General Internal Medicine

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS Professor of Medicine (Endocrinology, Adj), Johns Hopkins School of Medicine; Affiliate Research Professor, Bioinformatics and Computational Biology Program, School of Computational Sciences, George Mason University; Principal, C/A Informatics, LLC

Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Nutrition, American Society for Bone and Mineral Research, International Society for Clinical Densitometry, American College of Endocrinology, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Medical Informatics Association, Endocrine Society

Disclosure: Nothing to disclose.

Romesh Khardori, MD, PhD, FACP Professor of Endocrinology, Director of Training Program, Division of Endocrinology, Diabetes and Metabolism, Strelitz Diabetes and Endocrine Disorders Institute, Department of Internal Medicine, Eastern Virginia Medical School

Romesh Khardori, MD, PhD, FACP is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Diabetes Association, Endocrine Society

Disclosure: Nothing to disclose.

The editors wish to thank Magdi Salmon, MD, for his previous contributions to this article.

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