Type III Polyglandular Autoimmune Syndrome Follow-up

Updated: Sep 22, 2017
  • Author: KoKo Aung, MD, MPH, FACP; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
  • Print
Follow-up

Further Outpatient Care

Patients with polyglandular autoimmune syndrome (PAS) III must undergo lifelong monitoring of hormones and/or vitamin replacement therapy to avoid the development of new glandular failures.

Next:

Inpatient & Outpatient Medications

See Treatment.

Previous
Next:

Deterrence/Prevention

Many approaches are being tested for prevention of each component of glandular disease. Prevention trials currently are assessing the efficacy of inducing antigen-specific immune tolerance through the intravenous or subcutaneous administration of insulin in persons at risk who have evidence of decreased beta cell mass.

Relatives of patients with IMD who are at risk for the disease can be identified. Screening of the general population for each glandular failure is associated with high false-positive rates that preclude intervention studies. Some experts propose that periodic screening for another glandular failure should be performed in patients already diagnosed with PAS III.

Previous
Next:

Complications

Complications of PAS III include a constellation of complications associated with each glandular failure.

Previous
Next:

Prognosis

Prognosis of PAS III depends on the individual glandular failures involved.

No systematic studies of long-term prognosis of patients with PAS III have been conducted.

Previous
Next:

Patient Education

Education on diet, blood glucose monitoring, insulin injections, awareness of hypoglycemic symptoms and appropriate action, and use of glucagon kits is of paramount importance in managing type 1 diabetes mellitus (see Diabetes Mellitus, Type 1).

The need for continuous monitoring and adjustment of therapy should be stressed when educating patients with IMD, autoimmune thyroiditis, and PA.

Instruct patients to watch for the symptoms of failure of other endocrine glands.

For patient education resources, see the Endocrine System Center, as well as Anatomy of the Endocrine System.

Previous