Prolactinoma Differential Diagnoses

Updated: Nov 14, 2017
  • Author: Venkatesh Babu Segu, MD, MBBS, DM; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
  • Print

Diagnostic Considerations

If a female patient has amenorrhea, primary or secondary, consider other possible causes of the condition in the differential. If a patient (male or female) presents with infertility, consider all other causes of infertility in the differential.

If a patient has an elevated PRL level, other causes of hyperprolactinemia must be sought. These include the following:

  • Drugs - Such as phenothiazines, haloperidol, metoclopramide, methyldopa, reserpine, verapamil, tricyclic antidepressants, chronic opiate abuse, and cocaine [16]
  • Pituitary or hypothalamic causes - Including GH-secreting adenoma, nonfunctioning adenoma, pituitary stalk compression, empty sella syndrome, craniopharyngioma, meningioma, dysgerminoma, lymphocytic hypophysitis, other granulomatous conditions causing pituitary stalk distortion, and prior radiation to the area
  • Pregnancy
  • Primary hypothyroidism [17]
  • Chronic renal failure
  • Cirrhosis
  • Adrenal insufficiency
  • Chest wall lesions
  • Breast stimulation
  • Spinal cord lesions
  • Idiopathic causes

Differential Diagnoses