Prolactinoma Medication

Updated: Feb 15, 2022
  • Author: Venkatesh Babu Segu, MD, MBBS, DM; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Medication Summary

The drugs that are effective in the treatment of hyperprolactinemia are DA agonists. DA is the primary physiologic inhibitor of PRL secretion; however, DA is not used for treatment, because it does not cross the blood-brain barrier. Therefore, drugs that mimic the action of DA on the lactotrophs are used in the medical management of prolactinoma.


Dopamine agonists

Class Summary

Salutary effects on inhibition of PRL synthesis and secretion. These agents are also effective for reducing tumor size. [46]

Bromocriptine (Parlodel)

DOC for prolactinoma. Bromocriptine is the DA-receptor agonist with the longest record of use for hyperprolactinemia.

Cabergoline (Dostinex)

Now available in the United States for use in prolactinoma. Cabergoline is a long-acting DA agonist with efficacy and adverse effects that are similar to those of BEC.

Quinagolide (CV 205-502)

Specific DA-receptor (type 2) agonist with a relatively long duration of action. Quinagolide is not available in the United States.