Subacute Osteomyelitis (Brodie Abscess) Differential Diagnoses

Updated: Jun 02, 2022
  • Author: Khalid I Khoshhal, MBBS, FRCS(Edin), ABOS; Chief Editor: Thomas M DeBerardino, MD, FAAOS, FAOA  more...
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Diagnostic Considerations

Osteomyelitis is a known mimic of various diseases, and subacute osteomyelitis is no exception, having all of the presenting signs and symptoms of many bone tumors, both benign and malignant. The variety of radiographic presentations of subacute osteomyelitis has been emphasized by Gledhill. [31] The classic solitary lesion located in the metaphysis surrounded by reactive new bone presents little difficulty in diagnosis. However, extensive erosions of cortical bone, periosteal new bone formation, or both may add a more ominous dimension.

Patients with subacute osteomyelitis may occasionally be initially diagnosed with Ewing sarcoma or osteogenic sarcoma. From these observations, the following lesions must be considered among the differential diagnosis of subacute osteomyelitis: