Benign and Malignant Soft-Tissue Tumors Questions & Answers

Updated: Oct 29, 2021
  • Author: Vinod B Shidham, MD, FRCPath; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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Questions & Answers

Overview

What are soft-tissue tumors?

What is the pathophysiology of soft-tissue tumors?

What causes the high rate of local recurrence in soft-tissue tumors?

What is the pathophysiology of metastasis in soft-tissue tumors?

What is the role of genetics in the etiology of soft-tissue tumors?

What is the role of radiation in the etiology of soft-tissue tumors?

What is the role of chronic lymphedema in the etiology of soft-tissue tumors?

What are the environmental causes of soft-tissue tumors?

What are the infectious causes of soft-tissue tumors?

How does trauma cause soft-tissue tumors?

What is the prevalence of soft-tissue tumors?

What is the prognosis of soft-tissue tumors?

Presentation

What are the signs and symptoms of soft-tissue tumors?

What is included in the physical exam to evaluate soft-tissue tumors?

Workup

What is the role of lab tests in the workup of soft-tissue tumors?

What is the role of imaging studies in the workup of soft-tissue tumors?

What is the role of CT scanning in the workup of soft-tissue tumors?

What is the role of core needle biopsy in the workup of soft-tissue tumors?

What is the role of biopsy in the workup of soft-tissue tumors?

What are the biopsy techniques used in the workup of soft-tissue tumors?

What is the role of fine-needle aspiration biopsy (FNAB) in the workup of soft-tissue tumors?

What is the role of incisional biopsy in the workup of soft-tissue tumors?

What is the role of excisional biopsy in the workup of soft-tissue tumors?

What is the role of frozen sectioning and intraoperative cytology in the workup of soft-tissue tumors?

How are soft-tissue tumors classified?

What is the WHO classification of soft-tissue tumors?

How does WHO categorize soft tissue tumors?

What are the types of benign adipocytic tumors?

What are types of intermediate (locally aggressive) adipocytic tumors?

What are types of malignant adipocytic tumors?

What are types of benign fibroblastic/myofibroblastic tumors?

What are types of intermediate (locally aggressive) fibroblastic/myofibroblastic tumors?

What are types of intermediate (rarely metastasizing) fibroblastic/myofibroblastic tumors?

What are types of malignant fibroblastic/myofibroblastic tumors?

What are types of benign fibrohistiocytic tumors?

What are types of intermediate (rarely metastasizing) fibrohistiocytic tumors?

What are types of smooth-muscle tumors?

What are types of pericytic (perivascular) tumors?

What are types of skeletal-muscle tumors?

What are types of benign vascular tumors?

What are types of intermediate (locally aggressive) vascular tumors?

What are types of intermediate (rarely metastasizing) vascular tumors?

What are types of malignant vascular tumors?

What are types of chondro-osseous tumors?

What are types of GI stromal tumors (GISTs)?

What are types of benign nerve-sheath tumors?

What are types of malignant nerve-sheath tumors?

What are types of benign tumors of uncertain differentiation?

What are types of intermediate (locally aggressive) tumors of uncertain differentiation?

What are types of intermediate (rarely metastasizing) tumors of uncertain differentiation?

What are types of malignant tumors of uncertain differentiation?

What are types of undifferentiated/unclassified sarcomas?

What is the difference between benign, intermediate, and malignant soft-tissue tumors?

How are soft-tissue tumors staged?

What is the staging of tumor grade (G) in soft-tissue tumors?

What is the staging for primary tumor (T) in soft-tissue tumors?

What is the staging for regional lymph node involvement (N) in soft-tissue tumors?

What is the staging for distant metastasis (M) in soft-tissue tumors?

What are the AJCC GTNM stages of soft-tissue tumors?

Treatment

How are soft-tissue tumors treated?

What is the role of chemotherapy in the treatment of soft-tissue tumors?

What is the role of surgery in the treatment of localized soft-tissue tumors?

How are soft-tissue sarcomas of the extremities treated?

What is the role of surgery in the treatment of soft-tissue sarcomas of the extremities?

What is the role of radiation therapy in the treatment of soft-tissue sarcomas of the extremities?

What is the role of chemotherapy in the treatment of soft-tissue sarcomas of the extremities?

What is the role of surgery in the treatment of nonextremity soft-tissue sarcomas?

What is the role of surgery in the treatment of recurrent or metastatic soft-tissue sarcomas?

What is included in the postoperative care following surgery for soft-tissue tumors?

What are the possible complications of soft-tissue tumors?

What are the possible complications of soft-tissue tumors before completion of therapy?

What are the possible complications of soft-tissue tumors following therapy?

What is included in the long-term follow-up care of soft-tissue tumors?

Guidelines

Which organizations have released clinical practice guidelines on soft-tissue sarcoma (STS)?

What are the NCCN guidelines on imaging of soft-tissue sarcoma (STS)?

What are NCCN surgical guidelines for soft-tissue sarcoma (STS)?