Chondromyxoid Fibroma Clinical Presentation

Updated: Sep 27, 2022
  • Author: Stefanos F Haddad, MD; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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Approximately 70% of patients with chondromyxoid fibromas (CMFs) have symptoms at the time of diagnosis; the remaining lesions are discovered incidentally. Pain is the most common symptom and may be present for years. [17] Although the pain is typically mild, it may become severe with time, and night symptoms may be present. Patients may also report swelling and stiffness. These symptoms may be especially common around the knee and may cause a reduction in physical activity.

Pathologic fractures have been rarely reported, probably as a consequence of the slow growth of this tumor; the symptom of pain may be due to pending fracture through the lesion.


Physical Examination

Approximately 90% of CMFs involve the lower extremity. The proximal tibia metaphysis is the most common location, followed by the distal femoral metaphysis. [18] Long bones are involved much more frequently than are other bones, especially in younger patients. After the long bones, the pelvis is one of the more common sites. [19] Flat-bone involvement may rarely be seen in older patients. Craniofacial involvement occurs rarely. [20, 21]

Patients may have localized tenderness or swelling over a CMF lesion, and in rare cases, they may incur a pathologic fracture.