Synovial Sarcoma Questions & Answers

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2. Spira AI, Ettinger DS. The use of chemotherapy in soft-tissue sarcomas. Oncologist. 2002. 7 (4):348-59. [QxMD MEDLINE Link].

3. Siehl JM, Thiel E, Schmittel A, Hütter G, Deckert PM, Szelényi H, et al. Ifosfamide/liposomal daunorubicin is a well tolerated and active first-line chemotherapy regimen in advanced soft tissue sarcoma: results of a phase II study. Cancer. 2005 Aug 1. 104 (3):611-7. [QxMD MEDLINE Link].

4. Zagars GK, Ballo MT, Pisters PW, Pollock RE, Patel SR, Benjamin RS, et al. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients. Cancer. 2003 May 15. 97 (10):2530-43. [QxMD MEDLINE Link].

5. Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH, et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res. 2002 Jan 1. 62 (1):135-40. [QxMD MEDLINE Link].

6. Antonescu CR, Kawai A, Leung DH, Lonardo F, Woodruff JM, Healey JH, et al. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagn Mol Pathol. 2000 Mar. 9 (1):1-8. [QxMD MEDLINE Link].

7. Guillou L, Coindre J, Gallagher G, Terrier P, Gebhard S, de Saint Aubain Somerhausen N, et al. Detection of the synovial sarcoma translocation t(X;18) (SYT;SSX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for pathologists. A molecular analysis of 221 mesenchymal tumors fixed in different fixatives. Hum Pathol. 2001 Jan. 32 (1):105-12. [QxMD MEDLINE Link].

8. Kawai A, Woodruff J, Healey JH, Brennan MF, Antonescu CR, Ladanyi M. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med. 1998 Jan 15. 338 (3):153-60. [QxMD MEDLINE Link].

9. Kawaguchi S, Wada T, Ida K, Sato Y, Nagoya S, Tsukahara T, et al. Phase I vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma. J Transl Med. 2005 Jan 12. 3 (1):1. [QxMD MEDLINE Link]. [Full Text].

10. Knösel T, Heretsch S, Altendorf-Hofmann A, Richter P, Katenkamp K, Katenkamp D, et al. TLE1 is a robust diagnostic biomarker for synovial sarcomas and correlates with t(X;18): analysis of 319 cases. Eur J Cancer. 2010 Apr. 46 (6):1170-6. [QxMD MEDLINE Link].

11. Barco R, Garcia CB, Eid JE. The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1. PLoS One. 2009. 4 (4):e5060. [QxMD MEDLINE Link]. [Full Text].

12. Deshmukh R, Mankin HJ, Singer S. Synovial sarcoma: the importance of size and location for survival. Clin Orthop Relat Res. 2004 Feb. 155-61. [QxMD MEDLINE Link].

13. Ladenstein R, Treuner J, Koscielniak E, d'Oleire F, Keim M, Gadner H, et al. Synovial sarcoma of childhood and adolescence. Report of the German CWS-81 study. Cancer. 1993 Jun 1. 71 (11):3647-55. [QxMD MEDLINE Link].

14. Stefanovski PD, Bidoli E, De Paoli A, Buonadonna A, Boz G, Libra M, et al. Prognostic factors in soft tissue sarcomas: a study of 395 patients. Eur J Surg Oncol. 2002 Mar. 28 (2):153-64. [QxMD MEDLINE Link].

15. Mazeron JJ, Suit HD. Lymph nodes as sites of metastases from sarcomas of soft tissue. Cancer. 1987 Oct 15. 60 (8):1800-8. [QxMD MEDLINE Link].

16. Spillane AJ, A'Hern R, Judson IR, Fisher C, Thomas JM. Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J Clin Oncol. 2000 Nov 15. 18 (22):3794-803. [QxMD MEDLINE Link].

17. Thompson RC Jr, Garg A, Goswitz J, Cheng EY, Clohisy DR, Dusenbery K. Synovial sarcoma. Large size predicts poor outcome. Clin Orthop Relat Res. 2000 Apr. 18-24. [QxMD MEDLINE Link].

18. Mallen-St Clair J, Arshi A, Abemayor E, St John M. Factors Associated With Survival in Patients With Synovial Cell Sarcoma of the Head and Neck: An Analysis of 167 Cases Using the SEER (Surveillance, Epidemiology, and End Results) Database. JAMA Otolaryngol Head Neck Surg. 2016 Jun 1. 142 (6):576-83. [QxMD MEDLINE Link].

19. Al-Daraji W, Lasota J, Foss R, Miettinen M. Synovial sarcoma involving the head: analysis of 36 cases with predilection to the parotid and temporal regions. Am J Surg Pathol. 2009 Oct. 33 (10):1494-503. [QxMD MEDLINE Link].

20. Andreani L, Ipponi E, Mani O, Bayon G, Ruinato AD, Cosseddu F, et al. Synovial sarcomas: A single surgeon experience of 130 cases. J Surg Oncol. 2022 Sep. 126 (4):793-797. [QxMD MEDLINE Link].

21. Campbell C, Gallagher J, Dickinson I. Synovial sarcoma--towards a simplified approach to prognosis. ANZ J Surg. 2004 Sep. 74 (9):727-31. [QxMD MEDLINE Link].

22. Crowson MG, Lalich I, Keeney MG, Garcia JJ, Price DL. Clinicopathologic factors and adjuvant treatment effects on survival in adult head and neck synovial cell sarcoma. Head Neck. 2015 Mar. 37 (3):375-80. [QxMD MEDLINE Link].

23. Aytekin MN, Öztürk R, Amer K, Yapar A. Epidemiology, incidence, and survival of synovial sarcoma subtypes: SEER database analysis. J Orthop Surg (Hong Kong). 2020 Jan-Apr. 28 (2):2309499020936009. [QxMD MEDLINE Link]. [Full Text].

24. Moreau-Bachelard C, Campion L, Toulmonde M, Le Cesne A, Brahmi M, Italiano A, et al. Patterns of care and outcomes of 417 patients with METAstatic SYNovial sarcoma (METASYN): real-life data from the French Sarcoma Group (FSG). ESMO Open. 2022 Apr. 7 (2):100402. [QxMD MEDLINE Link].

25. Bridge JA. Cytogenetic and molecular cytogenetic techniques in orthopaedic surgery. J Bone Joint Surg Am. 1993 Apr. 75 (4):606-14. [QxMD MEDLINE Link].

26. Kind M, Stock N, Coindre JM. Histology and imaging of soft tissue sarcomas. Eur J Radiol. 2009 Oct. 72 (1):6-15. [QxMD MEDLINE Link].

27. Lessnick SL, Dei Tos AP, Sorensen PH, Dileo P, Baker LH, Ferrari S, et al. Small round cell sarcomas. Semin Oncol. 2009 Aug. 36 (4):338-46. [QxMD MEDLINE Link].

28. Ten Heuvel SE, Hoekstra HJ, Suurmeijer AJ. Diagnostic accuracy of FISH and RT-PCR in 50 routinely processed synovial sarcomas. Appl Immunohistochem Mol Morphol. 2008 May. 16 (3):246-50. [QxMD MEDLINE Link].

29. Bergh P, Meis-Kindblom JM, Gherlinzoni F, Berlin O, Bacchini P, Bertoni F, et al. Synovial sarcoma: identification of low and high risk groups. Cancer. 1999 Jun 15. 85 (12):2596-607. [QxMD MEDLINE Link].

30. Hindi N, Haas RL. Management of Synovial Sarcoma and Myxoid Liposarcoma. Surg Oncol Clin N Am. 2022 Jul. 31 (3):547-558. [QxMD MEDLINE Link].

31. Kojima Y, Shimoi T, Seo T, Yazaki S, Okuya T, Ohtake Y, et al. Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma. Oncology. 2022. 100 (7):370-375. [QxMD MEDLINE Link].

32. Fukukawa C, Hanaoka H, Nagayama S, Tsunoda T, Toguchida J, Endo K, et al. Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. Cancer Sci. 2008 Feb. 99 (2):432-40. [QxMD MEDLINE Link].

33. Crowson MG, Lalich I, Keeney MG, Garcia JJ, Price DL. Clinicopathologic factors and adjuvant treatment effects on survival in adult head and neck synovial cell sarcoma. Head Neck. 2015 Mar. 37 (3):375-80. [QxMD MEDLINE Link].

34. Ferrari A, Gronchi A, Casanova M, Meazza C, Gandola L, Collini P, et al. Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer. 2004 Aug 1. 101 (3):627-34. [QxMD MEDLINE Link].

35. Scheer M, Dantonello T, Hallmen E, Vokuhl C, Leuschner I, Sparber-Sauer M, et al. Primary Metastatic Synovial Sarcoma: Experience of the CWS Study Group. Pediatr Blood Cancer. 2016 Jul. 63 (7):1198-206. [QxMD MEDLINE Link].

36. Sakabe T, Murata H, Konishi E, Takeshita H, Ueda H, Matsui T, et al. Evaluation of clinical outcomes and prognostic factors for synovial sarcoma arising from the extremities. Med Sci Monit. 2008 Jun. 14 (6):CR305-310. [QxMD MEDLINE Link].

37. Ghert MA, Abudu A, Driver N, Davis AM, Griffin AM, Pearce D, et al. The indications for and the prognostic significance of amputation as the primary surgical procedure for localized soft tissue sarcoma of the extremity. Ann Surg Oncol. 2005 Jan. 12 (1):10-7. [QxMD MEDLINE Link].

38. Scheer M, Hallmen E, Vokuhl C, Fuchs J, Tunn PU, Münter M, et al. Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma. J Cancer Res Clin Oncol. 2022 Jun 10. [QxMD MEDLINE Link].

39. Pisters PW, Harrison LB, Leung DH, Woodruff JM, Casper ES, Brennan MF. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996 Mar. 14 (3):859-68. [QxMD MEDLINE Link].

40. Moreno Martín-Retortillo L, Andrés Moreno MM, Cañete Nieto A, Castel Sánchez V. Synovial sarcoma in children. A single centre experience. Clin Transl Oncol. 2007 Jul. 9 (7):468-70. [QxMD MEDLINE Link].

Bernardo Vargas, MD Consulting Staff, Department of Orthopedic Surgery, University Hospital of Geneva, Switzerland

Disclosure: Nothing to disclose.

Mark Clayer, MD, MBBS, FRACS, FAOrthA Head of Musculoskeletal Tumor Service, Department of Orthopaedics and Trauma, Queen Elizabeth Hospital; Senior Visiting Medical Specialist, Royal Adelaide Hospital and Women's and Children's Hospital, Australia

Mark Clayer, MD, MBBS, FRACS, FAOrthA is a member of the following medical societies: Australian Medical Association, Australian Orthopaedic Association

Disclosure: Received honoraria from Orthopedics hyperguide for independent contractor; Received grant/research funds from Stryker for employment.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Omohodion (Odion) Binitie, MD Medical Director, Assistant Member, Department of Sarcoma, Section Head, Orthopedics, Adolescent/Young Adult and Pediatric Orthopedic Oncology, Medical Director, Physical Therapy, Speech Therapy, and Rehabilitation Services, Assistant Fellowship Program Director, Musculoskeletal Oncology, Moffitt Cancer Center; Assistant Professor, Department of Oncologic Sciences, Department of Ortho and Sports Medicine, University of South Florida Morsani College of Medicine

Omohodion (Odion) Binitie, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, Children's Oncology Group, Florida Orthopaedic Society, Musculoskeletal Tumor Society

Disclosure: Nothing to disclose.

Howard A Chansky, MD Associate Professor, Department of Orthopedics and Sports Medicine, University of Washington Medical Center

Howard A Chansky, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons

Disclosure: Nothing to disclose.

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