Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Updated: Oct 05, 2017
  • Author: Bruce M Rothschild, MD; Chief Editor: Jeffrey D Thomson, MD  more...
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Overview

Practice Essentials

Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier disease, describes a phenomenon characterized by a tendency toward ossification of ligaments. It most characteristically affects the spine. [1, 2] (See the image below.) Ossification of the longitudinal ligaments (especially the anterior ligaments) of the spine produces a tortuous paravertebral mass anterior to and distinct (at least radiologically) from the vertebral bodies. [3] Grossly, the appearance is that of candle wax dripping down the spine.

Radiograph of the thoracic spine (anteroposterior Radiograph of the thoracic spine (anteroposterior view) showing osteophytes on the right side only, a feature typical of diffuse idiopathic skeletal hyperostosis.

While the thoracic anterior longitudinal ligament is ossified, the areas of ossification often meet without fusion. Motion actually is possible, in contrast to lumbar vertebral bridging, which is associated with loss of lumbar motion. The zygapophyseal and sacroiliac joints are not involved in DISH, and the intervening intervertebral disk space is preserved.

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Background

Diffuse idiopathic skeletal hyperostosis (DISH) was first described in 1948 by Forestier and Rotes-Querol in a report on nine patients, ranging in age from 50 to 73 years, who suffered from spinal rigidity and had exuberant osteophytes on radiologic studies. These authors termed the condition senile vertebral ankylosing hyperostosis. [4]

DISH is well represented in the zoologic and paleontologic record. It is found in 1-3% of baboons and monkeys, as well as in gorillas, bears, camels, horses, bison, musk oxen, canids, felids, and whales [5, 6, 7, 8, 9, 10, 11] ; DISH was also present in dinosaurs. [12, 13, 14] An age-dependent phenomenon, it occurs in 15-25% of older mammals.

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Pathophysiology

Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by a tendency toward ossification of ligament, tendon, and joint capsule (enthesial) insertions. [15] DISH is often a completely asymptomatic phenomenon, with no alterations detectable based on history or through physical examination.

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Epidemiology

Frequency

United States

Diffuse idiopathic skeletal hyperostosis (DISH) is present in approximately 19% of men and 4% of women older than 50 years. Frequency information in the US was derived from the study of nonselected skeletal/cemetery populations. [16]

International

In a study by Mori et al of 3013 Japanese patients (1261 females and 1752 males) with a mean age of 65 years, the computed tomograph– based prevalence of thoracic DISH was 8.7%. [17] The posterior longitudinal ligament of the cervical spine is ossified in 2% of Japanese individuals but in only 0.16% of white persons. [18] The anterior longitudinal ligament is calcified in 24% of patients with posterior longitudinal ligament ossification. [19]

DISH was reported in 17% of individuals in the Netherlands, paradoxically with male predominance. [20] A South African study of hospitalized patients 40 years of age and older found that the prevalence of DISH in African blacks was 3.8% in men and 4.2% in women; the prevalence rose with increasing age, from 1% in the 40-49 year age group to 13.6% in those over 70 years. [21]

Mortality/Morbidity

Diffuse idiopathic skeletal hyperostosis (DISH) appears to be a phenomenon rather than a disease. A double-blind controlled evaluation (in which controls and patients were drawn from the same population) revealed no associated pathology. Arthritis, bursitis, and tendinitis appeared no more frequently in patients with DISH than in controls. Any back pain present was no different in character or duration than that noted in control subjects. A history of back injury was actually found to be twice as frequent in control subjects as it was in patients with DISH. Back flexibility was no more limited in patients with DISH than it was in controls. In fact, patients with DISH who had decreased lumbar spinal motion had a lower frequency of back pain, implying that DISH may be protective. [16, 22] One study has showed that DISH may be protective against back pain. [23]

In another study, people with DISH were more likely to experience physical functional impairment. This included 1.72-fold increased odds of self-reported difficulty bending; worse grip strength; and in men only,  2.17-fold increased odds of being unable to complete 5 chair stands without using their arms. [24]

Race-, sex,-, and age-related demographics

The posterior longitudinal ligament of the cervical spine is ossified in 2% of Japanese individuals but in only 0.16% of whites.

Diffuse idiopathic skeletal hyperostosis is present in approximately 19% of men older than 50 years but is found in only 4% of women in this age group.

Diffuse idiopathic skeletal hyperostosis (DISH) is uncommon in patients younger than 50 years and is extremely rare in patients younger than 40 years.

A study from Finland [25] revealed the age frequency in Finnish men to be as follows:

  • 40-49 years - 0.3%
  • 50-59 years - 2.7%
  • 60-69 years - 8.4%
  • 70 years or older - 11.2%

The same study revealed the age frequency in Finnish women to be as follows:

  • 40-49 years - 0.2%
  • 50-59 years - 1.7%
  • 60-69 years - 4.3%
  • 70 years or older - 6.9%

In a study of community-dwelling men (n = 630) and women (n = 961), mean age 71.5 years, from the Rancho Bernardo Study, DISH was present in 25.6% of men and 5.5% of women. [24]

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